Laurence D. Rowe

ORCID: 0000-0002-1420-0754
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About
Contact & Profiles
Research Areas
  • Genomics and Chromatin Dynamics
  • Genomics and Phylogenetic Studies
  • Gene expression and cancer classification
  • RNA and protein synthesis mechanisms
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Bioinformatics and Genomic Networks
  • Biomedical Text Mining and Ontologies

Stanford University
2015-2023

The Encyclopedia of DNA Elements (ENCODE) Project is in its third phase creating a comprehensive catalog functional elements the human genome. This project includes an expansion assays that measure diverse RNA populations, identify proteins interact with and DNA, probe regions hypersensitivity, levels methylation wide range cell tissue types to putative regulatory elements. To date, results for almost 5000 experiments have been released use by scientific community. These data are available...

10.1093/nar/gkv1160 article EN cc-by Nucleic Acids Research 2015-11-02

Abstract The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create comprehensive catalog functional in the human genome. current database comprises more than 19000 genomics experiments across 1000 cell lines and tissues using wide array experimental techniques study chromatin structure, regulatory transcriptional landscape Homo sapiens Mus musculus genomes. All data, metadata, associated computational analyses created by ENCODE consortium are submitted Data...

10.1101/2023.04.04.535623 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2023-04-06

The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center (DCC) is responsible for organizing, describing and providing access to the diverse data generated by ENCODE project. description these data, known as metadata, includes biological sample used input, protocols assays performed on samples, files from results computational methods analyze data. Here, we outline principles philosophy define metadata in order create a standard that can be applied multiple genomic projects. In...

10.1093/database/baw001 article EN cc-by Database 2016-01-01

The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a comprehensive catalog functional initiated shortly after the completion Human Genome Project. current database exceeds 6500 experiments across more than 450 cell lines and tissues using wide array experimental techniques study chromatin structure, regulatory transcriptional landscape H. sapiens M. musculus genomes. All ENCODE data, metadata, associated computational analyses are submitted Data...

10.1371/journal.pone.0175310 article EN cc-by PLoS ONE 2017-04-12

Abstract The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort[1–6] to create a comprehensive catalog functional initiated shortly after the completion Human Genome Project[7][1]. current database exceeds 6500 experiments across more than 450 cell lines and tissues using wide array experimental techniques study chromatin structure, regulatory transcriptional landscape H. sapiens M. musculus genomes. All ENCODE data, metadata, associated computational analyses...

10.1101/044578 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2016-03-19
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