A5037939948- RNA regulation and disease
- Multiple Sclerosis Research Studies
- Genetics and Neurodevelopmental Disorders
- Cytokine Signaling Pathways and Interactions
- RNA and protein synthesis mechanisms
- Neurological diseases and metabolism
- Viral Infections and Immunology Research
- Lysosomal Storage Disorders Research
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Autism Spectrum Disorder Research
- Hereditary Neurological Disorders
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Metabolism and Genetic Disorders
- Protein Tyrosine Phosphatases
- Neurogenetic and Muscular Disorders Research
- Trypanosoma species research and implications
- Carbohydrate Chemistry and Synthesis
- Amino Acid Enzymes and Metabolism
- Migraine and Headache Studies
- Sympathectomy and Hyperhidrosis Treatments
- Parkinson's Disease Mechanisms and Treatments
Isfahan University of Medical Sciences
2016-2023
Shahid Beheshti University of Medical Sciences
2017
Shiraz University of Medical Sciences
2016
Abstract Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disorder of the central nervous system characterized by myelin loss axonal dysfunction. Increased production factors such as cytokines has been implicated in axon destruction. In present study, we compared expression level IL7R , NFATc2 RNF213 genes peripheral blood 72 MS patients (37 familial MS, 35 sporadic MS) 74 healthy controls (34 individuals with family history disease, 40 without history) via Real-time PCR. Our...
Abstract Alterations in the regulatory mechanisms that control process of myelination nervous system, may lead to impaired Multiple sclerosis. The Hippo pathway is an important mediator system and might contribute pathophysiology MS. This study examined via qPCR RNA expression YAP1 , TAZ CRB3 as key effectors also, VDR peripheral blood 35 sporadic, 37 familial MS patients; also 34 healthy first-degree relatives patients (HFR) 40 individuals without a family history disease (control). results...
Multiple sclerosis (MS) is a multifactorial inflammatory and autoimmune condition that lead to chronic neurodegeneration central nervous system (CNS) demyelination mainly affects young adults. The incidence prevalence rate of MS considerably vary in ethnicities geographic regions affecting women more than men. Interferon-β (IFN-β) the first-line disease management for MS, while majority affected members does not respond IFN-β. Numerous recent studies shown significant relationship between...
Abstract Objective Gamma‐aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult central nervous system, plays an important role during embryonic neural network formation. GAD67 is rate‐limiting enzyme GABA synthesis, and its deficiency leads to developmental epileptic encephalopathy 89 (DEE 89). Patients who suffered from this syndrome generally manifested severe profound neurodevelopmental delay, seizures, often congenital anomalies such as cleft palate or/and omphalocele....
Background: Detection of fetal DNA in maternal blood has been examined by many research groups for a few years; thereby, scientists have shorter way to take approach prenatal diagnosis abnormal pregnancies. The Y chromosome sequences recently become the most common applicable indices sex determination. Objectives: We conducted an algorithmic X and mini-Short Tandem Repeats (STRs) genotyping method that could solve problem false negative (no detection sequences) results previous methods....
Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, up to 50% of patients, clinical response does not occur. Ascertaining responding state, need a long-term follow-up, and this may lead delay use other effective medications. IFN-induced cascade its regulation considered play major role MS. Adenosine deaminase, RNA-specific (ADAR) dysregulation important IFN signaling pathway as an activity suppressor. Hence, we...
: Allgrove syndrome (triple A syndrome) is a rare autosomal recessive condition with adrenal insufficiency, achalasia and alacrima. This caused by mutations in AAAS gene. In this article we introduce six patients of syndrome, whom genetic analysis the triple gene was used to identify mutation, DNA extracted from blood samples. Exon 1 16 some introns were amplified polymerase chain reaction (PCR). PCR products evaluated complete nucleotide sequence analysis. After sequencing, alignment...
Abstract Background Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disorder of the central nervous system characterized by myelin loss axonal dysfunction. Increased production factors such as cytokines has been implicated in axon destruction myelin-less areas. In present study, we compared expression level IL7R , NFATc2 RNF213 genes peripheral blood 72 MS patients (37 familial MS, 35 sporadic MS) 74 healthy controls (34 individuals with family history disease, 40 without...