A5005693283- Agriculture Sustainability and Environmental Impact
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Anaerobic Digestion and Biogas Production
- Agricultural Science and Fertilization
- Computational Drug Discovery Methods
- Supramolecular Chemistry and Complexes
- Sustainable Agricultural Systems Analysis
- Agronomic Practices and Intercropping Systems
- Advanced Polymer Synthesis and Characterization
- Soil Carbon and Nitrogen Dynamics
- Lipid Membrane Structure and Behavior
- Crop Yield and Soil Fertility
- Bioenergy crop production and management
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Synthesis and Properties of Aromatic Compounds
- Alzheimer's disease research and treatments
Martin Luther University Halle-Wittenberg
2008-2020
Aggregation of amyloid peptides results in severe neurodegenerative diseases. While the fibril structures Aβ40 and Aβ42 have been described recently, resolution aggregation pathway evaluation potent inhibitors still remains elusive, particular view hairpin-region Aβ40. We here report preparation beta-turn mimetic conjugates containing synthetic turn region Aβ16-35, replacing 2 amino acids turn-region G25 - K28. The structure mimic induces both, acceleration fibrillation complete inhibition...
A synthetic strategy to efficiently prepare main-chain peptide-polymer conjugates probing their aggregation in solution is described. An situ tandem reaction based on aminolysis/thio-bromo "click" performed tether an amyloidogenic peptide fragment amyloid-β17-20 (Leu-Val-Phe-Phe (LVFF)) the ω-chain end of poly(diethylene glycol methyl ether acrylate) (PDEGA), prepared via reversible addition fragmentation chain transfer polymerization. Structural confirmation constructed PDEGA-LVFF (Mn,SEC =...
Chiral and achiral β-turn mimetic polymer conjugates were synthesized, their chiroptical properties investigated. helical poly(n-hexyl isocyanate)s (PHICs) with alkyne functional end groups (4.0–5.4 kDa) synthesized via coordination polymerization using either a chiral or an alkyne-functional organotitanium catalyst. The obtained polymers coupled structure the copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction, in turn allowing to tune distance between PHIC-helix center from 7 14...
Abstract: Investigation of model biomembranes and their interactions with natural or synthetic macromolecules are great interest to design membrane systems specific properties such as drug-delivery. Here we study the behavior amphiphilic β-turn mimetic polymer conjugates at air⁻water interface lipid membranes. For this endeavor synthesized two different types containing either hydrophobic polyisobutylene (PIB, Mn = 5000 g·mol-1) helical poly(n-hexyl isocyanate) (PHIC, 4000 g·mol-1), both...