A5061307677- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Eosinophilic Disorders and Syndromes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac electrophysiology and arrhythmias
- Ginseng Biological Effects and Applications
- Venous Thromboembolism Diagnosis and Management
- Gut microbiota and health
Hospital de Sant Pau
2022-2023
The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (γBB), and trimetyllisine (TML) in controls patients with venous thromboembolism (VTE) coagulation parameters.The study involved 54 VTE 57 controls. Platelet function, platelet hyperreactivity, adhesiveness, thrombosis-associated parameters, thrombin generation parameters were studied. Plasma TMAO, γBB, TML determination was performed using an...
Background and purpose Renal excretion of direct oral anticoagulants (DOACs) varies depending on the drug. Hypothetically, an increased glomerular filtration rate (GFR) may lead to suboptimal dosing a higher thromboembolic events incidence. However, real-world patient data do not support theoretical risk. The aim is analyse DOAC outcomes in patients with normal high (≥90 mL/min) GFR, focusing biological parameters thrombotic/haemorrhagic events. Methods Observational prospective...
Venous thromboembolism (VTE) is a common disease with high heritability. However, only small portion of the genetic variance VTE can be explained by known risk factors. Neutrophil extracellular traps (NETs) have been associated prothrombotic activity. Therefore, basis NETs could reveal novel factors for VTE. A recent genome-wide association study plasma cell-free DNA (cfDNA) levels in Genetic Analysis Idiopathic Thrombophilia 2 (GAIT-2) Project showed significant locus near ORM1. We aimed to...