A5080119092- Neurobiology of Language and Bilingualism
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Mental Health Research Topics
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury Research
- Dementia and Cognitive Impairment Research
- Reading and Literacy Development
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Cognitive Abilities and Testing
- Action Observation and Synchronization
- Defense, Military, and Policy Studies
- Cultural Differences and Values
- Hearing Impairment and Communication
- Cognitive and developmental aspects of mathematical skills
- Communication in Education and Healthcare
- Neuroendocrine regulation and behavior
- Migraine and Headache Studies
- Memory and Neural Mechanisms
- Gender and Technology in Education
University of North Carolina at Chapel Hill
2025
University of Denver
1978-2023
Duke University
2018-2021
University of Pennsylvania
2009-2015
Philadelphia University
2014
Institute on Aging
2014
Penn Center for AIDS Research
2014
Hospital of the University of Pennsylvania
2013
Pennsylvania Hospital
2013
Memorial Sloan Kettering Cancer Center
2009
A brief speech expression protocol that can be administered and scored without special training would aid in the differential diagnosis of 3 principal forms primary progressive aphasia (PPA): nonfluent/agrammatic PPA, logopenic variant semantic PPA.We used a picture-description task to elicit short sample, we evaluated impairments speech-sound production, rate, lexical retrieval, grammaticality. We compared results with those obtained by longer, previously validated further performance...
<h3>Background</h3> Significant heterogeneity in clinical features of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) cases with the pathogenic <i>C9orf72</i> expansion (C9P) have been described. To clarify this issue, we compared a large C9P cohort carefully matched non-expansion (C9N) known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy. <h3>Methods</h3> A retrospective case-control study was carried out using available...
<h3>Background</h3> Frontotemporal lobar degeneration (FTLD) is most commonly associated with TAR-DNA binding protein (TDP-43) or tau pathology at autopsy, but there are no <i>in vivo</i> biomarkers reliably discriminating between sporadic cases. As disease-modifying treatments emerge, it critical to accurately identify underlying in living patients so that they can be entered into appropriate etiology-directed clinical trials. Patients inclusions (FTLD-TAU) appear have relatively greater...
<h3>Importance</h3> An increasingly varied clinical spectrum of cases with amyotrophic lateral sclerosis (ALS) has been identified, and objective criteria for trial eligibility are necessary. <h3>Objective</h3> To develop a cerebrospinal fluid (CSF) biomarker sensitive specific the diagnosis ALS. <h3>Design, Setting, Participants</h3> A case-control study including 51 individuals ALS 23 disorder associated 4-repeat tauopathy was conducted at an academic medical center. <h3>Main Outcomes...
Background: Apathy, the major manifestation of impaired goal-directed behavior (GDB), is most common neuropsychiatric syndrome associated with behavioral variant frontotemporal degeneration (bvFTD). The and biological mechanisms apathy, however, are not well understood. We hypothesized that GDB has multiple components – including at least initiation, planning motivation supported by a network frontal brain regions. In this study, we examined hypothesis evaluating selective breakdown in...
<h3>Importance</h3> Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant primary progressive aphasia (naPPA), but well-controlled clinical measures grammatical are unavailable. <h3>Objective</h3> To develop a measure and examine this comparatively in PPA variants behavioural-variant frontotemporal degeneration (bvFTD) to assess neuroanatomic basis for these deficits with volumetric grey matter atrophy whole-brain fractional anisotropy...
Patients with the semantic variant of primary progressive aphasia, also known as dementia, and Alzheimer's disease have deficits in memory.However, few comparative studies been performed to determine whether these patient groups distinct memory impairments.We asked 15 patients aphasia 57 judge category membership coloured photos printed words that are members familiar natural manufactured categories, we related performance grey matter atrophy.We found both significantly impaired on this...
Shared symptoms and biological abnormalities between post-acute sequelae of SARS-CoV-2 infection (PASC) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) could suggest common pathophysiological bases would support coordinated treatment efforts. Empirical studies comparing these syndromes are needed to better understand their commonalities differences. We analyzed electronic health record data from 6.5 million adult patients the National COVID Cohort Collaborative. PASC ME/CFS...
To develop a continual process for linking more comprehensive external mortality data to electronic health records (EHRs) large healthcare system, which can serve as template other systems. Monthly updates of state death were arranged, and an automated pipeline was developed identify matches with patients in the EHR. A machine learning classifier used closely match human classification performance potential record matches. The linkage achieved high classifying matches, sensitivity 99.3%...
To relate changes in fractional anisotropy associated with behavioral variant frontotemporal dementia to measures of apathy and disinhibition.Apathy disinhibition are the 2 most common features dementia, these symptoms accelerated patient decline caregiver stress. However, little is known about how white matter disease contributes symptoms.We collected neuropsychiatric data, volumetric magnetic resonance imaging, diffusion-weighted imaging 11 patients who met published criteria for had an...
Our ability to form abstract representations of objects in semantic memory is crucial language and thought. The utility this information relies both on the sensory-motor feature knowledge stored long-term executive processes required retrieve, manipulate, evaluate a task-relevant manner. These complementary components can be differentially impacted by aging. We investigated processing normal aging using functional magnetic resonance imaging (fMRI). Young older adults were asked judge whether...
To relate fractional anisotropy (FA) changes associated with the semantic and logopenic variants of primary progressive aphasia (PPA) to measures lexical retrieval.We collected neuropsychological testing, volumetric magnetic resonance imaging, diffusion-weighted imaging on variant PPA (svPPA) (n = 11) (lvPPA) 13) patients diagnosed using published criteria. We also acquired neuroimaging data a group demographically comparable healthy seniors 34). FA was calculated analyzed white matter (WM)...
To determine the prognostic utility of tauopathy-associated single nucleotide polymorphisms (SNPs) in sporadic behavioral-variant frontotemporal dementia (bvFTD).Eighty-one patients with bvFTD were genotyped for SNPs at rs8070723 (microtubule-associated protein tau [MAPT]) and rs1768208 (myelin-associated oligodendrocyte basic [MOBP]). We performed a retrospective case-control study comparing age onset disease duration between carriers ≥1 polymorphism allele noncarriers these SNPs....
The performance and well-being of university students is influenced by many factors, including self-control affect regulation, but little known about how these factors relate. We therefore analyzed data from a multi-site research project that assessed trait self-control, anxiety in longitudinal cohort design (N = 1314) using structural equation modeling. specifically tested hypotheses upon entering school, would predict outcomes during students’ third year, this relationship be mediated...
<b><i>Introduction:</i></b> Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. <b><i>Objective:</i></b> To this aim, we developed and tested one-time intervention that integrates behavioral skills training with concurrent repetitive transcranial magnetic stimulation (rTMS). <b><i>Methods:</i></b> Forty-six adults who met criteria for at least one DSM-5...
Abstract To achieve our moment-to-moment goals, we must often keep information temporarily in mind. Yet, this working memory (WM) may compete with demands for attention the environment. Attentional and WM functions are thought to operate by similar underlying principles, they engage overlapping fronto-parietal brain regions. In a recent fMRI study, bilateral parietal cortex BOLD activity displayed an interaction between visual dual-task demands. However, prior studies also suggest that left...