A5102020329- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Hepatitis C virus research
- Pain Management and Opioid Use
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Histone Deacetylase Inhibitors Research
- COVID-19 and Mental Health
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Pharmacological Effects and Assays
- Medicinal Plant Pharmacodynamics Research
- Boron Compounds in Chemistry
- Reproductive System and Pregnancy
- Sarcoidosis and Beryllium Toxicity Research
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- COVID-19 Impact on Reproduction
- Cancer Immunotherapy and Biomarkers
- Aortic Disease and Treatment Approaches
- Caveolin-1 and cellular processes
- Advanced Glycation End Products research
- Cardiac tumors and thrombi
- RNA Interference and Gene Delivery
- Escherichia coli research studies
University of South China
2025
Sichuan University
2018-2024
West China Hospital of Sichuan University
2018-2023
The Fifth People's Hospital of Anyang
2022
WuXi AppTec (China)
2020
University of Alabama at Birmingham
2020
The University of Queensland
2015-2019
Hebei Agricultural University
2010
Jiangxi Provincial Children's Hospital
2007
The pathogenesis of Ureaplasma urealyticum infection is linked to the host inflammatory response; however, specific molecular mechanisms underlying this phenomenon have not been fully elucidated. GrpE a chaperonin that accelerates ADP release and ATP binding DnaK, thereby enhancing chaperone function HSP70 system under stress. However, alternative activities such as pro-inflammatory responses remain poorly understood. In study, we report U. exerts cytokine-inducing virulence factor toward...
The immune memory of over 400 million COVID-19 convalescents is not completely understood. In this integrated study, we recorded the post-acute sequelae symptoms and tested memories, including circulating antibodies, B cell, CD4 or CD8 T cell responses a cohort 65 patients 1-year after infection. Our data show that 48% them still have one more all maintain at least components. chances having better are associated with peak disease severity. We did four-time points sampling per subject to...
Abstract Purpose: The purpose of this study is to investigate the potential interplay between opioid analgesia and tumor metastasis through modulation μ-opioid receptor (MOR), Toll-like 4 (TLR4) activation, matrix degradation potential. Experimental Design: Plasma samples were collected from 60 patients undergoing elective lower limb joint replacement preoperatively at 3, 6, 24 hours after surgery; pain scores documented same time points. Opioid administration was recorded converted into...
Opioids modulate the tumor microenvironment with potential functional consequences for growth and metastasis. We evaluated effects of morphine administration on circulating proteolytic profile tumor-free mice. Serum from morphine-treated (1 or 10 mg/kg, i.p. every 12 h) saline-treated mice was collected at different time points tested
Macrophages are abundant in the tumor microenvironment where they adopt a pro-tumor phenotype following alternative polarization induced by paracrine factors from cancer and stromal cells. In contrast, classically activated macrophages have tumoricidal activities, such that of tumor-associated has become novel therapeutic target. Toll-like receptor 4 engagement promotes classical activation macrophages, recent literature suggests TLR4 agonism to prevent metastasis promote survival...
A 63-year-old woman with a five-month history of pulmonary epithelioid hemangioendothelioma (PEH) presented to the emergency department, due worsening dyspnea and chest pain. The electrocardiography showed pattern ST-segment elevation in leads I, AVL, poor R-wave progression consistent anterolateral ischemia. Emergent coronary angiography revealed severe stenosis left main artery. Then, contrast-enhanced computed tomography scan indicated right artery narrowing by compression metastasized...
Abstract Background With the relief of zero-COVID prevention policy in China, great changes COVID-19 pandemic took place. Against this backdrop, we aimed to investigate impact shift on mental health younger adults China. Methods A cross-sectional study was conducted using an online questionnaire survey between January 1st and February 28th, 2023. The estimate prevalence sleep quality, anxiety, depression among participants aged 18-45years old. Pearson's correlation analysis used explore...
Abstract Induced resistance after anticancer agent treatment is the main reason for cancer relapse and short median survival of patients. Here we employed in vivo vitro approaches to establish optimize a drug-resistant platform based on patient-derived xenografts (PDXs). PDXs derived from lung patients who acquired drug reproduced insensitivity standard target therapies mice. Alternatively, was induced established PDX by continuously exposing with dosage increasing, which demonstrated...