We aim to develop and validate an interpretable machine-learning model that can provide critical information for the clinical treatment of critically ill patients with acute myocardial infarction (AMI). All data was extracted from multi-centre database (training internal validation cohorts: MIMIC-III/-IV, external cohort: eICU). After comparing different models several unbalanced processing methods, best performance selected. Lasso regression used build a compact model. Seven evaluation PR,...

This study was aimed to investigate miR‐216a expression in pancreatic cancer and determine its effects on proliferation. found downregulated tissues as compared benign lesions. JAK2 identified a gene target. Further, vivo treatment of PANC‐1 tumors with reduced protein levels the tumor volume. In conclusion, may function suppressor regulating cells by targeting JAK/STAT pathway. Further studies larger number patient samples are necessary fully explore diagnostic therapeutic potential for cancer.

Abstract Background Vitamin D deficiency and systemic inflammation share common pathological mechanisms in muscle loss, cardio-pulmonary function decline, abnormal metabolism, which are linked to chronic conditions, senescence, early mortality. However, their combined effect on mortality older adults has not been well established. This study longitudinal aimed explore the independent associations of serum 25-hydroxyvitamin [25(OH)D] high sensitivity C-reactive protein (hs-CRP) with risk...

Abstract A fabric hydrogel composite hernia mesh with biomechanical and mesh–tissue interface dual compliance is designed for scarless abdominal wall reconstruction. The composed of a polyester knitted chitosan–polyacrylamide complex. mechanical properties the are adjusted to resemble human by alkali treatment chitosan achieve good compliance. An adhesion group introduced into that forms covalent bonds tissue, eliminating need suturing, reducing stress concentration at fixation site,...

Financial protection is a key dimension of Universal Health Coverage (UHC), and social medical insurance an effective measure to provide financial protection. The aim this study examine the impact urban-rural integration on impoverishment in China.We collected time policy 337 prefecture-level cities across China, combined with longitudinal database China Labor-force Dynamics Survey (CLDS) from 2012-2016, used difference-in-differences (DID) method multiple periods at city level effect...

<italic>γ</italic>-Valerolactone (GVL) is a promising bio-based platform molecule with significant potential for energy applications. The production of GVL via biomass-based levulinic acid (LA) an important reaction. To enhance the conversion and selectivity non-precious-metal catalysts in LA-to-GVL process to better understand key factors influencing this conversion, we conducted series experiments. In study, supported Cu-Ni bimetallic (Cu-Ni2/Al2O3) were prepared using layered...

BACKGROUND: The aim of this study was to compare primary efficacy indicators a low-cost, electrospun, nanoscale P(LLA-CL)/fibrinogen patch with porcine small intestine submucosa for hernia repair. STUDY DESIGN: A randomized, single-blind, controlled multicenter trial performed in 3 hospitals Shanghai. Eligible patients (20 75 years old) unilateral, reducible groin hernias were randomly assigned (1:1) electrospun (experimental group) or (control groups. Patients treated the Lichtenstein...

The oral status of an individual is a vital aspect their overall health. However, older adults in nursing homes have higher prevalence frailty and poor health, particularly the context global aging. objective this study to explore association between among residing homes.The involved 1280 individuals aged 60 above from Hunan province, China. A simple questionnaire (FRAIL scale) was used evaluate physical frailty, while Oral Health Assessment Tool assess status. frequency tooth brushing...

Chronic inflammation is considered one of the main mechanisms leading to frailty. It has been demonstrated that tea consumption reduces chronic inflammation. Few epidemiological studies have investigated association between and frailty.This study aimed analyze frailty in Chinese older adults.Between March May 2021, we enrolled 2,144 adults aged ≥60 years Jinan City, Shandong Province, China, using multi-stage stratified cluster sampling. We assessed Tilburg Frailty Indicator (TFI) frequency...

A novel superhydrophilic hybrid scaffold was created by electrospinning a mixture of poly(l-lactic acid-co-ε-caprolactone) and formulated fibrinogen. The scaffolds possess the combined benefits each individual component, such as moderate mechanical strength excellent biocompatibility. In vitro studies also revealed that endothelial cells seeded on achieved relatively high level cell attachment after three days culture significant increase in proliferation rate seven culture, compared with...

Background While high blood pressure has been linked to cognitive impairment, the relationship between low pressure, especially hypotension, and impairment not well studied. Therefore, this study aimed assess prevalence of hypotension in seniors China, association function impairment. Methods The data was derived from 2018 wave Chinese Longitudinal Healthy Longevity Survey (CLHLS). Systolic pressures (SBP) diastolic (DBP) were measured by objective examination. version Mini-Mental State...

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumour with increasing incidence and high mortality. Liver kinase B1 (LKB1) regulates cellular energy metabolism cell division affects immune microenvironment. This study aimed to uncover the underlying function mechanism of LKB1 in ICC. To determine correlation between levels clinicopathological features, expression profile ICC tissue specimens was examined by qRT-PCR western blotting. In vitro experiments were conducted examine...

Abstract Objective Considering the potential of adipose‐derived stem cells (ADSCs) migrating towards cancer cells, this study was performed to explore function tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) modified ADSCs on development and progression hepatocellular carcinoma (HCC). Methods were extracted from human adipose tissues identified through immunofluorescence flow cytometry. Oil red staining alizarin clarify differentiation ADSCs. AAV‐CMV‐sTRAIL transfected into...

Colorectal cancer (CRC) is a malignant tumor of the gastrointestinal tract and leading cause cancer‑associated mortality worldwide. Mex‑3 RNA binding family member A (MEX3A) promotes progression multiple types cancer, including ovarian cervical cancer. However, to best our knowledge, role MEX3A in CRC not completely understood. Therefore, present study aimed investigate function CRC. The mRNA protein expression levels cells were analyzed using reverse transcription‑quantitative PCR western...

Abstract Background Existing evidence highlights that exposure to secondhand smoke (SHS) is a risk factor for pregnant women’s health and possibly affected by individual characteristics. This study aimed explore the effect of socioeconomic status (SES) on SHS among women in third trimester interaction age. Methods A total 678 nonsmoking with median age 29.0 years from 14 communities medium-sized city were recruited this survey. Exposure was defined as self-reported smoking habit...

Polypropylene (PP) mesh is one of the most widely used artificial meshes to treat hernias. It has many advantages but can also cause chronic inflammation, pain, and adhesion. In inguinal hernia repair, PP may have a negative effect on reproductive system. this study, protective an electrospun fibrous membrane was investigated in autologous control experiment repair rabbits. Tissue adhesions, obstructions spermatic cord, orchiatrophy, system abnormalities were highly correlated mainly...

e18010 Background: Apatinib is a small tyrosine kinase inhibitor targeting the vascular endogenous growth receptor 2 (VEGFR-2) that shows potent antitumor activities in various advanced cancers via inhibition of neo-angiogenesis. The effect apatinib recurrent or metastatic head and neck has not been fully demonstrated. Methods: Patients with consecutively treated our institute by from January 2015 to December 2020 were enrolled. Daily 250 mg 500 was given without chemotherapy according...

<title>Abstract</title> Thymic Epithelial Tumor (TET), a rare thoracic tumor, including thymoma and thymic carcinoma, has limited research on prognostic markers compared to carcinoma. Using the cBiportal database, we analyzed gene expression, methylation, mutation data in TETs. We explored relationship between <italic>GTF2I</italic> L424H pathology through differential pathway enrichment analyses, COX regression develop risk score.<bold> </bold>Compared with<italic> GTF2I </italic>wild-type,...

Objective To analyze the clinical value of laparoscopic and hybrid technique for repair incisional hernia. Methods The data 70 cases hernia undergoing from Jan 2014 to Dec 2015 in Huadong Hospital were analyzed retrospectively. Results All operated on successfully recovered. The operation time was (60±27) min (120±32)min repair.The length incision (6±4) cm (8±6) hybrid. Postoperative complications included seroma 1 case group , fat liquefation group. All cured with conservative...