A5048303225- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Urological Disorders and Treatments
- Immune Response and Inflammation
- Gallbladder and Bile Duct Disorders
- Minimally Invasive Surgical Techniques
- Ethics and Legal Issues in Pediatric Healthcare
- Hepatocellular Carcinoma Treatment and Prognosis
- Genital Health and Disease
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Healthcare cost, quality, practices
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
- Healthcare Systems and Technology
- Psoriasis: Treatment and Pathogenesis
- Cancer, Hypoxia, and Metabolism
- Eosinophilic Esophagitis
- Drug-Induced Hepatotoxicity and Protection
- Angiogenesis and VEGF in Cancer
- Primary Care and Health Outcomes
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Surgical Simulation and Training
- Nanoplatforms for cancer theranostics
Oxford University Hospitals NHS Trust
2024-2025
University of Pittsburgh Medical Center
2017-2018
University of Pittsburgh
2017-2018
Kasturba Medical College, Manipal
2011-2014
Nonalcoholic steatohepatitis (NASH) is a progressive, inflammatory form of fatty liver disease. It the most rapidly rising risk factor for development hepatocellular carcinoma (HCC), which can arise in NASH with or without cirrhosis. The signals promoting progression to HCC remain largely unknown. propensity neutrophils expel decondensed chromatin embedded proteins, known as neutrophil extracellular traps (NETs), has been shown be important chronic conditions and cancer progression. In this...
Abstract Hepatic ischemia reperfusion (I/R) is a clinically relevant model of acute sterile inflammation leading to reverberating, self-sustaining inflammatory response with resultant necrosis. We hypothesized that computerized dynamic network analysis (DyNA) 20 mediators could help dissect the sequence post-I/R mediator interactions induce injury. Although majority measured become elevated in first 24 h, we predicted only few would be secreted early process and serve as organizational...
// Samer Tohme 1,* , Marina V. Kameneva 1,2,3,* Hamza O. Yazdani 1 Vikas Sud Julie Goswami Patricia Loughran 1,4 Hai Huang Richard L. Simmons and Allan Tsung Department of Surgery, University Pittsburgh Medical Center, Pittsburgh, PA, USA 2 McGowan Institute for Regenerative Medicine, 3 Bioengineering, 4 Center Biologic Imaging, Cell Biology, * These authors have contributed equally to this work Correspondence to: Tohme, email: Keywords : liver, Ischemia reperfusion injury, drag reducing...
A 23-year-old man presented to us with reports of right-sided lower abdominal pain for 1 day associated anorexia and nausea. Abdominal ultrasound scan showed inflammed appendix. His routine blood investigations revealed mild neutrophilic leucocytosis eosinophilia. He was taken up emergency laparoscopic appendicectomy. Intraoperatively, after dividing the appendix between endoloop ligatures three pinworms (Entrobious vermicularis) fell into abdomen. One them reached wall (figure 1), its...
Abstract Background A recent large retrospective cohort study reported a higher risk of bile duct injury associated with robotic cholecystectomy when compared to the laparoscopic approach. Considering that most training pathways, including one followed in UK, utilise as index procedure, such findings mandate evaluation safety profile UK ensure its use an alternative approach is not putting patients at risk. We aimed conduct multi-centre observational evaluate performed within HPB Robotic...
Foreign body granulomas are common in the hand and foot. Diagnosis of same is often delayed or missed, especially unusual locations paediatric age group. Radiographs usually reveal an osteolytic lesion with absence periosteal reaction non-metallic foreign bodies not visualised plain radiographs. An ultrasound MRI can delineate body. Clinical radiological presentation mimics that a tumour hence rightly called pseudotumour. We present case thorn-induced pseudotumour fibula 5-year-old boy.
Abstract Surgery is known to accelerate the growth and progression of metastases in patients undergoing oncological resections with 50-60% having recurrent metastasis after resection making it a major reason for treatment failure. This impedes efficacy adjuvant chemotherapy overall prognosis patient. Studies have proved that inflammatory cascade initiated by surgery increases metastatic mediated through specific mechanism neutrophil cell death called Neutrophil Extracellular Traps (NETs). We...