A5015764040- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Acne and Rosacea Treatments and Effects
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Neonatal skin health care
- Vascular Malformations and Hemangiomas
- Cutaneous lymphoproliferative disorders research
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Chemotherapy-related skin toxicity
- Eosinophilic Disorders and Syndromes
- Transgenic Plants and Applications
- Genetic and rare skin diseases.
- Epigenetics and DNA Methylation
- Pediatric Pain Management Techniques
- Melanoma and MAPK Pathways
- Pressure Ulcer Prevention and Management
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Bartonella species infections research
University of California, San Diego
2015-2025
Rady Children's Hospital-San Diego
2021-2024
University of California, Riverside
2023
Twinleaf (United States)
2016
Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, vivo they encounter multiple signals that control their varied functions homeostasis, immunity, and disease. Here, we identify roles of Rev-erb nuclear receptors regulating responses mouse complex tissue damage wound repair. Rather than reinforcing a specific program macrophage polarization, Rev-erbs repress subsets genes are activated by TLR IL4, TGFβ, damage-associated molecular patterns (DAMPS)....
In the United States, 40-50% of patients with atopic dermatitis (AD) have moderate-to-severe disease, often necessitating advanced systemic therapies (ASTs; biologics or Janus kinase inhibitors). TARGET-DERM AD is an observational, longitudinal registry that tracks natural history and treatment AD, including disease. Among enrollees, we defined 4 patient subgroups: AST-Naïve, AST-Retrospective (AST initiated prior to enrollment), AST-Prospective at after AST-Failed (failed any point). This...
Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. Treatment regimens typically include topical and systemic immunosuppressive medications. Although effective, corticosteroids are sometimes poorly tolerated in elderly patient, contributing to overall morbidity mortality of BP. Dupilumab a monoclonal antibody targeting interleukin 4 receptor alpha (IL4R?), approved for treatment atopic dermatitis, as well moderate severe asthma chronic...
Abstract A 12‐year‐old boy presented with a 2‐week history of persistent pruritic edematous plaques one day after he received the first dose BNT162b2 COVID‐19 mRNA vaccine. skin biopsy showed urticarial dermatitis tissue eosinophilia consistent diagnosis vaccine‐associated eosinophilic cellulitis, polyethylene glycol as potential trigger.
Several drugs can be associated with hyperpigmentation of mucosa or skin. They include antibiotic, antimalarial, antineoplastic, and psychotropic medications.To describe a 42-year-old woman amitriptyline-associated photo-distributed to review drug-induced the skin.The features amitriptyline-induced are presented. Using PubMed, following terms were searched relevant citations assessed discussed for context: amitriptyline, chlorpromazine, citalopram, desipramine, drug-associated, drug-induced,...
Glucocorticoids (GCs) are generally envisioned as immunosuppressive, but in conditions such rosacea and perioral dermatitis they can lead to increased skin inflammation. In lung epithelia, GCs promote expression of the proinflammatory cytokine CCL20, which contributes steroid-resistant asthma. skin, CCL20 stimulates inflammation by recruiting T helper 17 lymphocytes dendritic cells, is elevated papulopustular rosacea.To understand if, how, affect human keratinocytes. was assessed...
BACKGROUND Pulsed dye lasers (PDLs) are well-established for treatment of capillary malformations but unable to penetrate the depth needed treat deeper vascular lesions. A combined approach using a penetrating wavelength with “superficial” could more comprehensively than PDL alone. OBJECTIVE To evaluate safety and efficacy long-pulsed 1064-nm neodymium:yttrium–aluminum–garnet (LP Nd:YAG) in conjunction 532-nm potassium titanyl phosphate (532-nm KTP) laser wavelengths venous malformations....
Cutaneous side effects such as acneiform eruption, xerosis, and paronychia are frequently observed in patients undergoing treatment with epidermal growth factor receptor (EGFR) inhibitors for non-small cell lung cancer other solid tumors. Interestingly, these appear to positively correlate length of remission, indicating that disruption homeostatic EGFR signaling the skin may serve a marker therapeutic inhibition We report case woman metastatic remission being treated inhibitor, erlotinib,...
Atypical fibroxanthoma (AFX) is a rare cutaneous fibrohistiocytic tumor that typically arises on chronically sun-damaged skin, such as the head and neck, nondescript ulcerated papule, nodule, or tumor. The clinical prognosis usually favorable metastasis rare. Pleomorphic dermal sarcoma (PDS), undifferentiated pleomorphic sarcoma, recently introduced diagnostic moniker for AFX-like tumors with more aggressive histologic features necrosis vascular invasion. exact relationship between AFX PDS...