A5002142725- Parkinson's Disease Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Retinal Development and Disorders
- Proteoglycans and glycosaminoglycans research
- Neurobiology and Insect Physiology Research
- Mesenchymal stem cell research
- Nuclear Receptors and Signaling
- Microfluidic and Bio-sensing Technologies
- Electrohydrodynamics and Fluid Dynamics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Folate and B Vitamins Research
- Thyroid Cancer Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine Tumor Research Advances
- Microtubule and mitosis dynamics
- Thyroid Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Visual perception and processing mechanisms
University of York
1998-2019
Research Institute for Endocrine Sciences
2015
Shahid Beheshti University of Medical Sciences
2015
Bone marrow stromal cells (BMSCs, also called bone-marrow-derived mesenchymal cells) provide hematopoietic support and immunoregulation contain a stem cell fraction capable of skeletogenic differentiation. We used immortalized human BMSC clonal lines for multi-level analysis functional markers subsets. All clones expressed typical cell-surface antigens; however, with trilineage differentiation capacity exhibited enhanced vascular interaction gene sets, whereas non-differentiating were...
Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision. As both mammalian fly visual systems contain neurons, we investigated the effect LRRK2 mutations (the most common cause inherited PD) on Drosophila electroretinograms (ERGs). We reveal progressive photoreceptor function in flies expressing LRRK2-G2019S neurons. The photoreceptors showed elevated autophagy, apoptosis mitochondrial disorganization. Head sections...
Our understanding of Parkinson's disease (PD) has been revolutionized by the discovery disease-causing genetic mutations. The most common these is G2019S mutation in LRRK2 kinase gene, which leads to increased activity. However, link between activity and PD unclear. Previously, we showed that dopaminergic expression human LRRK2-G2019S transgene flies led an activity-dependent loss vision older animals hypothesized this may have preceded a failure regulate neuronal correctly younger animals....
Abstract Microfilaments in freshly adhering CG‐4 cells and differentiated oligodendrocytes are concentrated at the tips edges of rapidly forming processes while microtubules new extend from a spot α‐tubulin staining cell body to periphery. In motile bipolar cells, microfilaments heavily flattened end one process along rim body: main splay out into body. oligodendrocytes, many tips, filopodia fine processes, but not obvious where separate bundles microtubules, which diverge branch points,...
Rat CG-4 line progenitor oligodendrocytes passaged in neuroblastoma-conditioned medium onto a poly-L-lysine-coated surface adopt bipolar morphology with long processes and proliferate. On untreated or albumin- poly-L-glutamate-coated surfaces the same such cells show little process extension but still proliferate forming clumps of loosely attached to substratum. Transfer these cell results migration out rapid elaboration morphology. In differentiation containing 1% foetal bovine serum extend...
Human neurological diseases such as epilepsy and Parkinson's disease are associated with visual deficits that can be measured both psychophysically electrophysiological methods. Until recently, however, it has been difficult to examine the physiological genetic origin of these directly. Drosophila melanogaster (the fruit fly) is a common animal model relatively simple system excellent tractability but little know about effects on responses in this organism. Here, we show recordings...
Rat CG-4 line progenitor oligodendrocytes passaged in neuroblastoma-conditioned medium onto a poly-L-lysine-coated surface adopt bipolar morphology with long processes and proliferate. On untreated or albumin- poly-L-glutamate-coated surfaces the same such cells show little process extension but still proliferate forming clumps of loosely attached to substratum. Transfer these cell results migration out rapid elaboration morphology. In differentiation containing 1% foetal bovine serum extend...