A5061575530- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Animal Behavior and Reproduction
- Insect and Pesticide Research
- Plant Virus Research Studies
- Ubiquitin and proteasome pathways
- Inflammatory Bowel Disease
- Microscopic Colitis
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Cancer Research and Treatments
- Hereditary Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Neurobiology and Insect Physiology Research
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- IL-33, ST2, and ILC Pathways
- Histone Deacetylase Inhibitors Research
- Evolution and Genetic Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Receptor Mechanisms and Signaling
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
University of Haifa
2018-2023
Tel Aviv University
2008-2021
Wolfson Medical Center
2009
University of Massachusetts Amherst
2000
Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in amyotrophic lateral sclerosis (ALS) pathology. Although the disease9s etiology is not fully understood, it thought to involve a non–cell-autonomous mechanism alterations RNA metabolism. Here, we identified reduced levels miR126-5p presymptomatic ALS male mice models, an increase its targets: axon destabilizing Type 3 Semaphorins their coreceptor Neuropilins. Using compartmentalized <i>in vitro</i>...
Abstract Microtubule (MT)-based transport is an evolutionary conserved process finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, primarily catalyzed a vesicular pool of N-acetyltransferase 1 (Atat1), promotes the recruitment and processivity molecular motors along MT tracks. However, mechanism that controls Atat1 activity remains poorly understood. Here, we show ATP-citrate lyase (Acly) enriched in vesicles provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. In...
Pediatric onset of Crohn disease (CD) is characterized by male sex predominance while adult-onset demonstrates female predominance. It has been postulated that this phenomenon may be genetically determined or due to an effect estrogen on age onset. Interleukin (IL)-6 modulates the TH17 pathway, and IL-6 promoter modulated estrogen, possibly linking inflammation presence estrogen. The aim our study was investigate whether differences in genotype could explain earlier onset.We genotyped 333...
Social insect colonies exhibit colony-level phenotypes such as social immunity and task coordination, which are produced by the individual phenotypes. Mapping genetic basis of requires associating phenotype with genotypes in colony. In this paper, we examine alternative approaches to DNA extraction, library construction, sequencing for genome wide association studies (GWAS) traits using a population sample Cataglyphis niger ants. We evaluate accuracy allele frequency estimation from pool...
Abstract In social insects, due to considerable polyphenism as well high level of hybridization, the delimitation species can be challenging. The genus Cataglyphis presents a diversification, making it an excellent model with which study evolutionary paths. Israel appears “hot spot” for recent speciation in this genus. Although previous studies have described multiple Israel, genetic has questioned existence some these historically species. present focuses on apparent complex, C. niger...
Species are the fundamental units upon which evolutionary research is based. In insects, due to high level of hybridization, delimitation such species can be challenging. The genus Cataglyphis presents a diversification, making it an excellent model with study paths. Israel appears 'hot spot' for recent speciation in this genus. Although previous studies have described multiple Israel, genetic has questioned existence some these historically species. present focuses on apparent complex that...
Abstract In social insects, non-nestmates interactions are typically agonistic and many factors may influence the degree of exhibited aggression. Two these physical proximity between nests chemical dissimilarity colonies’ signatures. We studied a population sample 43 colonies Cataglyphis niger ants distributed along transect ∼4KM. This geographic distribution allowed us to examine correlations aggression levels with distances. Ants were collected before mating season, when sexuals (unmated...
Abstract Nestmate recognition is the basis for cooperation within social insect colonies. Quantitative variation in cuticle hydrocarbons (CHCs) used nestmate ants and other insects. We carried out a Genome Wide Association Study (GWAS) of CHCs desert ant Cataglyphis niger by sampling 47 colonies, fully sequencing six workers from each colony, measuring relative amounts their CHCs. Under Gestalt colony odour model, interactions between nestmates, which are being transferred mixed, essential...
Abstract Social insect colonies exhibit colony-level phenotypes such as social immunity and task coordination, which are the sum of individual phenotypes. Mapping genetic basis requires associating phenotype with genotypes in colony. In this paper, we examine alternative approaches to DNA extraction, library construction sequencing for genome wide association (GWAS) studies traits. We evaluate accuracy allele frequency estimation a pool individuals (pool-seq) from each colony either...
Abstract Cuticualar hydrocarbons play an important role in chemical communication social insects, serving, among other things, as nestmate, gender, dominance and fertility recognition cues. In ants, however, very little is known about the precopulatory signals cuticular carry. These may serve affecting sex pheromones aphrodisiacs or reliable for idiosyncratic traits, which indirectly affect sexual selection. this study, we examined, first time, Cataglyphis genus, sex-specific variability...
Abstract Microtubule (MT)-based transport is an evolutionary conserved processed finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, which catalyzed the N-acetyltransferase 1, Atat1, promotes recruitment and processivity of molecular motors along MT tracks. However, mechanisms that controls Atat1 activity remains poorly understood. Here, we show a pool vesicular ATP-citrate lyase Acly acts as rate limiting enzyme to modulate controlling availability...