A5015317889- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- Sexual function and dysfunction studies
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Anorectal Disease Treatments and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Health, Nursing, Elderly Care
- Genital Health and Disease
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Glioma Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Radiopharmaceutical Chemistry and Applications
- Organ Donation and Transplantation
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
Universidade do Porto
2016-2025
Hospital Universitário de Brasília
2025
Hospital de São João
2015-2024
Universidade Estadual de Feira de Santana
2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2024
Centro Universitário UNINOVAFAPI
2024
National Institute for Health Research
2024
University of Birmingham
2024
Instituto Português de Oncologia Francisco Gentil
2021-2024
IPO Porto
2021-2024
Abstract Cancer immunoediting is a dynamic process of crosstalk between tumor cells and the immune system. Herein, we explore fast zebrafish xenograft model to investigate innate contribution this process. Using multiple breast colorectal cancer cell lines zAvatars, find that some are cleared (regressors) while others engraft (progressors) in xenografts. We focus on two human derived from same patient show contrasting engraftment/clearance profiles. polyclonal xenografts mimic intra-tumor...
We evaluated the role of bladder C-fiber input in involuntary detrusor activity patients with idiopathic instability.Filling cystometry and a voiding chart were done 13 instability. The first contraction, maximal cystometric capacity, daily frequency number episodes urinary incontinence determined. A 50 nM. solution resiniferatoxin, specific neurotoxin, was then instilled for 30 minutes. Patients reevaluated 90 days later.Resiniferatoxin instillation delayed or suppressed contractions during...
Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders.Capsaicin solution (1 mM.) instilled into the bladder of 16 spinal hyperreflexia, instability hypersensibility.Frequency decreased in 14 and continence achieved 10 incontinent cases. Mean first desire void maximal cystometric capacity increased significantly. These effects lasted for 6 12 months were renewed following repeat treatment.Bladder afferent desensitization capsaicin is promising motor...
Study Type – Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does study add? Androgen deprivation therapy (ADT) is commonly used as a primary treatment for patients with prostate cancer (PCa) who are not eligible radical options. ADT also in PCa neo‐adjuvant hormone to reduce volume down‐stage disease before radiotherapy curative intent. The present showed that gonadotropin hormone‐releasing (GhRH) antagonist degarelix non‐inferior combined LHRH agonist goserelin...
We investigated urinary levels of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived in healthy individuals patients with overactive bladder.Urine from 40 volunteers, half them male female, was collected the morning, afternoon evening on 2 occasions 3 months apart. Morning urine samples were 37 female naïve bladder. A total 24 followed. Urine after a 3-month lifestyle intervention antimuscarinic treatment (oxybutynin 10 mg, extended release). Urinary...
We evaluate the efficacy and safety of repeated intratrigonal injections onabotulinum toxin A in patients with bladder pain syndrome/interstitial cystitis.This is a single center, long-term, prospective study which 16 women cystitis refractory to standard treatment received 4 consecutive A. Onabotulinum (100 U) was injected under cystoscopic control 10 trigonal sites, each receiving U 1 ml saline. General anesthesia used all treatments. Re-treatment allowed 3 months after injection. Outcome...
Overactive bladder syndrome (OAB) is a highly prevalent urinary dysfunction, with considerable economic and human costs. Clinical diagnosis of OAB still based on subjective symptoms. A new accurate, objective noninvasive test to diagnose assess therapeutic outcome lacking. Recent studies in lower tract (LUT) dysfunctions, particularly patients, indicate that proteins (neurotrophins, prostaglandins, cytokines), serum C reactive protein, detrusor wall thickness are altered, such changes could...
Abstract Background and study aims Previous studies have suggested a high prevalence of musculoskeletal injuries (MI) in endoscopists. Little evidence has come from European countries. Our main aim was to evaluate the prevalence, type, impact MI among Portuguese We also sought identify risk factors for development, severity number endoscopy-related MI. Material methods A 48-question electronic survey developed by multidisciplinary group. The sent all members Society Gastroenterology (n =...
Abstract Background Perianal fistulas are the most common type of anal involvement in Crohn’s disease (CD), affecting approximately one-third patients.1 They associated with a poor quality life and can lead to significant disability.2 Despite combined medical surgical treatments, many patients experience refractory disease, up 20% requiring proctectomy, which results permanent stoma.3 Consequently, investigating factors that may influence outcomes perianal is critical area research CD. One...
Background: Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) is a rare variant of Renal (RCC). MTSCC has been regarded as an indolent subtype RCC conveying good prognosis. However, recently some cases have described presenting or evolving with metastasis, showing aggressive behaviour. We aim to describe clinical characteristics, treatment, prognosis survival. Methods: retrospectively reviewed all diagnosed at our institution from 1 January 2008 31 December 2022. Electronic health records...
A ansiedade é um sinal de alerta diante uma ameaça desconhecida e conflituosa, que indica perigo iminente, entretanto, quando essa reação hormonal excessiva desproporcional ao risco real, passa-se fisiológica para patológica. Esse sentimento tem se tornado comum no ambiente acadêmico principalmente em situações esses alunos são avaliados com provas seminários. realização do Exame Nacional Ensino Médio, atualmente a porta entrada o ensino superior, evento ansiogênico os preparam prova,...
Conforme o Boletim Epidemiológico (2023), número de casos hepatite C e B ainda são altos, como a escola é um espaço privilegiado para práticas promoção saúde prevenção agravos à doenças. Esse trabalho buscou esclarecer situação da comunidade escolar, principalmente dos alunos do ensino básico, acerca dessa infecção partir das conclusões trabalhos científicos realizados no âmbito acessados através base dados Google Acadêmico. Em síntese, dentro artigos estudados, desses, vinte constatam que...