A5075484902- Cardiovascular Health and Disease Prevention
- Advanced X-ray Imaging Techniques
- Cardiovascular Disease and Adiposity
- Elasticity and Material Modeling
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Electron Microscopy Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Machine Learning in Materials Science
- Enzyme Structure and Function
- Connective tissue disorders research
Ghent University Hospital
2015-2022
Ghent University
2017-2021
In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures BAPN/AngII-infused mice, a mouse model for dissection. Ascending thoraco-abdominal samples from n = 3 control animals 10 mice (after 3, 7 14 days infusion, total 24 samples) were scanned. A steep increase number was already noted after BAPN/AngII-infusion. The largest found at latest time points. 133 affected only first...
To validate and compare the deformable image registration parotid contour propagation process for head neck magnetic resonance imaging in patients treated with radiotherapy using 3 different approaches-the commercial MIM, open-source Elastix software, an optimized version of it.Twelve cancer previously were considered. Deformable evaluated by considering images acquired before after end treatment. registration, based on free-form deformation method, available MIM compared to Elastix. Two...
Objective: Thoracic endovascular aortic repair (TEVAR) for type B dissection (TBAD) aims to induce false lumen (FL) thrombosis by sealing intimal tears between the true (TL) and FL, blocking inflow into FL. Incomplete of FL is correlated with poor clinical outcome. We hypothesize that number major minor branches arising from affects patency may negatively influence TEVAR induced thrombosis. Methods: Computed tomography (CT)-scans 89 patients diagnosed TBAD [best medical treatment (BMT) n =...
In computational aortic biomechanics, and arterial tissue are typically modelled as a homogeneous layer, making abstraction not only of the layered structure intima, media adventitia but also microstructure that exists within these layers. Here, we present novel method to visualize tunica along entire circumference vessel. To end, developed pressure-inflation device is compatible with synchrotron-based phase-contrast imaging. Using freshly excised left common carotid arteries from n = 12...
Synchrotron-based x-ray phase-contrast imaging allows for detailed 3D insight into the microstructure of soft tissue and is increasingly used to improve our understanding mouse models cardiovascular disease. Two techniques dominate field: grating interferometry, with superior density contrast at mid lower microscopic resolutions, propagation-based phase contrast, facilitating high-resolution imaging. The choice between these depends on which features one interested in visualizing thus highly...
Images taken during and after RT for head neck cancer have the potential to quantitatively assess xerostomia. Image information may be used as biomarkers of effects on parotid glands with significant support adaptive treatment strategies. We investigated possibility extract based in-room CT images (kVCT, MVCT), acquired daily image-guided radiotherapy head-and-neck patients, in order predict individual response terms toxicity. Follow-up MRI were also investigate long term gland deformation.
Abstract Introduction Marfan syndrome (MFS) is caused by a defect in fibrillin-1, which binds TGF-beta via interaction with latent binding proteins (LTBPs). The role of MFS controversial. Objectives use dedicated mouse models for MFS, defects interfering and function, to gain insights into the signaling aneurysm formation dissection. Material & methods Mice lacking site LTBPs (Fbn1H1Δ/+ Fbn1H1Δ/H1Δ), mice truncated fibrillin-1 (Fbn1GT-8/+), combination (Fbn1GT-8/H1Δ) were subjected...