The antioxidant activity ofwater, ethanol and methanol Hieracium pilosella L.extracts is reported. antioxidative was tested by spectrophotometrically measuring their ability to scavenge a stable DPPH· free radical reactive hydroxyl trapped DMPO during the Fenton reaction, using ESR spectroscopy. Total phenolic content total flavonoid were evaluated according Folin-Ciocalteu procedure, colorimetric method, respectively. A HPLC method used for identification of some compounds (chlorogenic...

Sulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides action involves competitive inhibition folic acid synthesis which prevents growth and reproduction microorganisms. Due to this action, belong group bacteriostatic agents. Although they have been applied in therapy for more than 70 years, still drugs choice treatment several conditions diseases. A wider application is limited by bacterial resistance side effects. Antimicrobial their...

In this review, the biosynthesis of allicin (allyl thiosulfinate) by enzymatic transformation alliin and various methods its synthesis with detailed investigation mechanisms kinetics are summarized. A convenient method is also described for determination stability utility inclusion complexes pharmacologically active agent ?-cyclodextrins in increasing stability. Allicin initial precursor production ajoene ((E)- (Z)-4,5,9-trithiadodeca- 1,6,11-triene 9-oxides) vinyldithiin...

The surface quality of denture base resins allows for easy colonization by microorganisms including Candida albicans and Staphylococcus aureus, which cause major diseases the oral cavity such as stomatitis. widespread use silver nanoparticles (AgNPs) in various fields medicine has led to research their possible application dentistry, mostly prevention bacterial adhesion, proliferation, biofilm formation. aim study was synthesize cold heat-curing modified with AgNPs AgCl, evaluate potential...

Poly(D,L-lactide) synthesis using tin(II) 2-ethylhexanoate initiated ring-opening polymerization (ROP) takes over 30 hours in bulk at 120 °C. The use of microwave makes the same process with initiator much faster and energy saving, a reaction time about minutes 100 Here, poly(lactide) was done reactor, frequency 2.45 GHz maximal power 150 W. temperature controlled via infra-red system for in-bulk-measuring, maintained Different molar ratios monomer initiator, [M]/[I], 1,000, 5,000 10,000...

Fruit is rich in different phenolic compounds which are recognized as potential natural medicaments and have been used folk medicine for centuries. In order to evaluate phenol composition, cornelian cherry (Cornus mas) fruit leaf extracts were subjected the spectrophotometric HPLC analysis. The radical scavenging activity was estimated using DPPH test antimicrobial by disc diffusion microwell dilution tests. All showed high content from 89.89 ? 0.45 117.34 1.40 mg f gallic acid equivalents...

The aim of the paper was to develop simple procedures for preparation inclusion complexes ellagic acid (EA) with cyclodextrins (CDs) and investigate their antioxidant antimicrobial activity.The structural characterization carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), nuclear magnetic resonance (NMR) methods. phase solubility technique used interactions between 'host' 'guest' molecules estimate molar ratio them. activity EA were determined.The...

This study investigates the biological activity of pure allantoin (PA) and aqueous extract comfrey ( Symphytum officinale L .) root (AECR) standardized to content. Cell viability proliferation epithelial (MDCK) fibroblastic (L929) cell line were studied by using MTT test. Anti‐irritant potential was determined measuring electrical capacitance, erythema index (EI) transepidermal water loss artificially irritated skin young healthy volunteers, 3 7 days after application creams gels with PA or...

This work aimed to isolate the essential oil from nutmeg (Myristica fragrans Houtt.) seed, determine qualitative and quantitative chemical composition of obtained oil, as well examine its antioxidant antimicrobial activity. The was by Clevenger-type hydrodistillation disintegrated seed (hydromodulus 1:15 m/V, extraction time 180 minutes). determined GC/MS GC/FID analysis. Twenty-five compounds were identified in most abundant monoterpene hydrocarbon sabinene (42.3 %). activity...

In the present study, we investigated phenolic composition, antioxidant, antimicrobial and cytotoxic activities of ethanolic extracts from leaves stems leek (Allium porrum L.), which are growing in Central Serbia (Balkan) is used everyday human food. The standard spectroscopic methods were applied to determine total phenols flavonoids, where compounds estimated by HPLC analysis. results indicated that highest content flavonoids found Allium plant (93.34 25.14 mg/g). major were: rosmarinic...

Curcumin comes from the plant species Curcuma longa and shows numerous pharmacological activities. There are curcumin formulations with gels or cyclodextrins in order to increase its solubility bioavailability. This paper presents formulation of complex 2-hydroxypropyl-β-cyclodextrin a thermosensitive hydrogel, based on N-isopropylmethacrylamide N-isopropylacrylamide ethylene glycol dimethacrylate as crosslinker. The product was characterized by chemical methods also FTIR, HPLC, DSC, SEM,...

The essential oils from flowers of Lavandula officinalis L. (L. = angustifolia Mill.) were obtained by two hydrodistillation techniques: standard (technique I) and modified II) Clevenger hydrodistillation. yield, kinetics, composition antimicrobial activity investigated. higher yield oil was technique II. new analytical kinetics model Lavandulae defined. analyzed gas chromatography-mass spectroscopy (GC-MS). There are differences in chemical compositions the different techniques....

The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). effect time, ethanol concentration, solid-to-liquid ratio, temperature on the content in extracts estimated both mathematical models. MLP 4-3-1 with exponential function hidden layer linear output used for describing process. model more superior compared CCD due to better prediction ability. According model, suggested optimal conditions are: time 120 min,...

This paper presents the synthesis and physico-chemical characterization of iron(II) gluconate as a potential antianemic drug for oral administration. Iron(II) was synthesized from sodium sulphate precursors. The reaction product purified by treating crude mixture with acidic basic ion exchange resins removal Na+ i SO42- ions. purity greater than 90% obtained after evaporation in vacuum evaporator, treatment aprotic solvent drying desiccator over dehydration agent. Molar ratio 1:2 iron...

The main goal of this study was to develop a liposome formulation with sulfanilamide and investigate the liposomes impact on its release stability UV-A/UV-B UV-C irradiation. Liposome dispersions incorporated were prepared by thin-film hydration method role investigated using dialysis method. Comparatively, in phosphate buffer solution subject as well UV irradiation providing for possibilities kinetics analysis. In vitro drug demonstrated that 20% released from within 1 h is approximately...

The aim of this paper was the identification bioactive compounds in green tea extract enriched with quercetin. extraction performed under reflux for 60 min using absolute ethanol at solid-to-liquid ratio 1:18 (m/v). mass spectrometry method an electrospray interface applied and tuned quercetin standard. Mass spectra were recorded negative positive ionization modes ion source voltage 4.95 kV, current 2.61 μA, capillary temperature 275 °C, 50 V, sheath gas pressure 137 KPa auxiliary 13.9 KPa....