Background: Many women complain of difficulty maintaining euglycemia during the luteal phase menstrual cycle. This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and phases with type 1 diabetes. Methods: Women using infusion pumps (n = 5, mean age 29.2 ± 10.9 years, body mass index 24 1.8 kg/m2) underwent frequently sampled intravenous glucose tolerance tests each cycle phase. Insulin effectiveness were determined by Minimal Model...

Background: Self-care is believed to improve heart failure (HF) outcomes, but the mechanisms by which such improvement occurs remain unclear. Methods: We completed a secondary analysis of cross-sectional data collected on adults with symptomatic HF test our hypothesis that effective self-care associated less myocardial stress and systemic inflammation. Multivariate logistic regression modeling was used determine if better reduced odds having serum levels amino-terminal pro-B-type natriuretic...

Background: Caregivers of stroke survivors often suffer depressive symptoms that interfere with their own health. Early recognition may lead to attenuation and better health well-being for caregivers.Objective: We examined characteristics caregivers associated caregivers' in the early poststroke period.Methods: conducted a prospective, longitudinal exploratory observational study convenience sample 63 older adult (≥ 65 years) recruited from urban acute-care settings. enrolled by 2 weeks (T1)...

Caregivers of stroke survivors experience high rates mental and physical morbidity. Stroke has sudden onset, the outcome is not immediately known. Uncertainties surrounding new caregiving role may only necessitate major changes in lives family caregivers but also contribute to negative health outcomes for caregiver.

Adaptation to infectious diseases or models of such as immune stimulation with exogenous administration bacterial lipopolysaccharide (LPS) cytokines involve complex autonomic, endocrine, and behavioral responses mediated by the central nervous system. The purpose this study is determine neural pathways from brainstem activating nucleus amygdala after LPS injections in rats. Fos immunohistochemistry was performed a marker neuronal activation rats prepared retrograde tracing agents Fluorogold...

Hypoglycemia reduces sympathoadrenal responses to subsequent hypoglycemic bouts by an unknown mechanism. To assess whether such hypoglycemia-associated autonomic failure is due actual brain damage, male Sprague-Dawley rats underwent 1-h of insulin-induced (5 U/kg i.v.) hypoglycemia (1.6-2.8 mmol/l) 1 or 3 times on alternate days. Rats remained alert and were rescued with intravenous glucose at 60-80 min. Plasma epinephrine corticosterone significantly reduced during the second third bouts....

Posttraumatic hyperthermia (PTH) is a noninfectious elevation in body temperature that negatively influences outcome after traumatic brain injury (TBI). We sought to (1) characterize clinically relevant model and (2) investigate potential cellular mechanisms of PTH. In study I, patterns were analyzed for 1 week male rats severe lateral fluid percussion (FP) ( n=75) or sham n=17). After injury, 27% surviving animals experienced PTH, while 69% acute hypothermia with slow return baseline. A...

Intensive insulin therapy in patients with type 1 diabetes mellitus reduces long-term complications; however, intensive is also associated a three-fold increase hypoglycemic episodes. The present study conscious rats characterizes the physiologic and neuropathologic consequences of single episode moderate hypoglycemia. In this model, intravenous used to reduce plasma glucose 30 35 mg/dL for 75mins. This insult acutely induces hypoglycemia-associated autonomic failure (HAAF), epinephrine...

Studies show that self-care improves diabetes mellitus (DM) outcomes; however, previous studies have focused on maintenance, and little is known about management. The objective of this study to examine the influence DM maintenance management number hospitalizations hospitalization days. A cohort design with secondary analysis data from Health Retirement Study 2002-2004 was used. Data 726 adults were analyzed logistic regression negative binomial adjusting for covariates. Self-care...

The distribution and time course of Fos expression in neurons the central nucleus amygdala (CeA) were studied endotoxemic rats two separate experiments. In each case, severity endotoxin (lipopolysaccharide; LPS) challenge was characterized by using physiological outcome variables, including blood pressure heart rate. Throughout rostrocaudal extent CeA, extensive staining found 3 hours after injection with a hypotensive dose Salmonella enteritidis LPS. Hypotension alone has been reported to...

Rats that develop diet-induced obesity (DIO) on a 31% fat [high-energy (HE)] diet have defective sensing and responding to altered glucose levels compared with diet-resistant (DR) rats. Thus we postulated they would also counterregulatory responses (CRR) insulin-induced hypoglycemia (IIH). Chow-fed selectively bred DIO DR rats underwent three sequential 60-min bouts of IIH separated by 48 h. Glucose fell comparably, but had 22-29% lower plasma epinephrine (Epi) during the first two than By...

Academic health centers are strategically positioned to impact the of lesbian, gay, bisexual and transgender (LGBT) populations by advancing science, educating future generations providers, delivering integrated care that addresses unique needs LGBT community. This report describes early experiences Penn Medicine Program for Health, highlighting favorable environment led its creation, mission structure Program, strategic planning process used set priorities establish collaborations,...

The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular luteal phases menstrual cycle women with premenstrual syndrome (PMS).Subjects were screened for PMS using Penn Daily Symptom Rating (DSR) scale. Each subject had two overnight admissions (once each phase) Hospital University Pennsylvania. They performed 3-day diet histories prior hospitalization. After admission, subjects received dinner a snack,...

Caregivers' stress following a family member's stroke is likely accentuated by its associated uncertainty. The purpose of the current study was to examine effect uncertainty on caregivers' perceived and physiological (i.e., salivary cortisol). A prospective, longitudinal observational conducted with convenience sample 40 caregivers survivors recruited from acute care settings. Linear mixed models were used. Greater higher (p < 0.001), but not = 0.32 waking, p 0.06 evening), over first 6...