A5061222620- Skin Protection and Aging
- Protease and Inhibitor Mechanisms
- Collagen: Extraction and Characterization
- Antimicrobial Peptides and Activities
- Bone and Dental Protein Studies
- Contact Dermatitis and Allergies
- S100 Proteins and Annexins
- Bee Products Chemical Analysis
Wellcome Centre for Cell-Matrix Research
2024
Henry Royce Institute
2022
University of Manchester
2022
Manchester Academic Health Science Centre
2021
Matrix Research (United States)
2020
Both protease- and reactive oxygen species (ROS)-mediated proteolysis are thought to be key effectors of tissue remodeling. We have previously shown that comparison amino acid composition can predict the differential susceptibilities proteins photo-oxidation. However, predicting protein susceptibility endogenous proteases remains challenging. Here, we aim develop bioinformatics tools (i) cleavage site locations (and hence putative susceptibilities) (ii) compare predicted vulnerabilities skin...
Introduction: Exposure to chronic, low-dose UV irradiation (UVR) can lead premature ageing of the skin. Understanding which proteins are affected by acute UVR and photo-dynamically produced reactive oxygen species (ROS) could help inform strategies delay photoageing. Conventional biochemical analyses be used characterize UVR/ROS-induced damage on a protein-by-protein basis we have previously shown using SDS-PAGE that collagen I plasma fibronectin respectively resistant susceptible...
Abstract Age, disease, and exposure to environmental factors can induce tissue remodelling alterations in protein structure abundance. In the case of human skin, ultraviolet radiation (UVR)-induced photo-ageing has a profound effect on dermal extracellular matrix (ECM) proteins. We have previously shown that ECM proteins rich UV-chromophore amino acids are differentially susceptible UVR. However, this UVR-mediated mechanism alone does not explain loss UV-chromophore-poor assemblies such as...