A5000433403- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Genomics and Rare Diseases
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- COVID-19 diagnosis using AI
- ATP Synthase and ATPases Research
- Cellular Mechanics and Interactions
- HVDC Systems and Fault Protection
- Hearing, Cochlea, Tinnitus, Genetics
- Wnt/β-catenin signaling in development and cancer
- Congenital heart defects research
- Wound Healing and Treatments
- Ideological and Political Education
- Mitochondrial Function and Pathology
- Medical Imaging and Pathology Studies
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
Korea University Medical Center
2024
Yonsei University
2008-2024
National Health Insurance Service
2021-2024
Severance Hospital
2020-2024
National Health Insurance Service Ilsan Hospital
2021-2024
Sichuan University
2020
Nvidia (United Kingdom)
2020
Gachon University Gil Medical Center
2018-2019
Gachon University Gil Hospital
2017-2018
Zhongshan Hospital
2017
Skin is the outermost layer of human body that constantly exposed to environmental stressors, such as UV radiation and toxic chemicals, susceptible mechanical wounding injury. The ability skin repair injuries paramount for survival it disrupted in a spectrum disorders leading pathologies. Diabetic patients often suffer from chronic, impaired wound healing, which facilitate bacterial infections necessitate amputation. Here, we studied effects gallic acid (GA, 3,4,5-trihydroxybenzoic acid;...
Abstract Background Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3β (GSK3β). However, the mechanism by which VPA differentiation is not understood. Results We report here 1 mM simultaneously induces reduces proliferation of basic fibroblast growth factor (bFGF)-treated embryonic day 14 (E14) rat cerebral cortex neural...
In this study, we examined the signaling pathways activated by Wnt5a in endothelial differentiation of embryonic stem (ES) cells and function during vascular development. We first found that Wnt5a(-/-) mouse (mES) exhibited a defect differentiation, which was rescued addition Wnt5a, suggesting is required for ES cells. Involvement both beta-catenin protein kinase (PK)Calpha mES requiring indicated activation PKCalpha Wnt5a(+/-) but not also or knockdowns inhibited Wnt5a-induced Moreover,...
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation reactive oxygen species (ROS). In addition, also involved the modulation of fibroblasts proliferation. However, regulatory function wound repair human is not yet clearly elucidated. To investigate roles healing process keratinocytes, three MAAs,...
Most developmental screening tools in Korea are adopted from foreign tests. To ensure efficient of infants and children Korea, a nationwide tool with high reliability validity is needed.This study aimed to independently develop, standardize, validate the Korean Developmental Screening Test for Infants Children (K-DST) neurodevelopmental disorders Korea.The standardization validation conducted 2012-2014 3,284 subjects (4-71 months age) resulted first edition K-DST. The restandardization...
CXXC5 is a member of small subset proteins containing CXXC-type zinc-finger domain. Here, we show that transcription factor activating Flk-1, receptor for vascular endothelial growth factor. and Flk-1 were accmulated in nucli membrane mouse embryonic stem cells (mESCs), respectively, during their differentiation. overexpression induced both endothelium-differentiated mESCs human umbilical vein (HUVECs). In vitro DNA binding assay showed direct interaction on the promoter region, mutation its...
Abstract Aims. We aimed to delineate the phenotypic spectrum of SCN2A ‐related developmental and epileptic encephalopathy (DEE) determine effectiveness various treatment modalities, including sodium channel blockers ketogenic diet. Methods. Eleven patients with DEE were included in study. The characteristics mutations, electroclinical features, clinical course, response modalities analysed. Results. 11 aged between 0.4 9.7 years. onset seizures ranged from neonate (six patients) infant (four...
Sur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, roles of Sur8 in cellular physiologies are poorly understood. In this study, was severely repressed course neural progenitor cell (NPC) differentiation cerebral cortex developing rat embryos. Similarly, also critically reduced cultured NPCs, which were induced by removal basic fibroblast growth factor (bFGF). regulation occurs at level rather than mRNA as revealed both situ...
A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of proposed mechanisms action is that KD inhibits mammalian target rapamycin (mTOR) pathway. To test this clinically, study aimed to determine efficacy in patients with pathologically confirmed focal cortical dysplasia (FCD) due genetically identifiable mTOR pathway dysregulation.A cohort FCD after epilepsy surgery who were screened for presence germline somatic mutations related peripheral blood resected...
This study aimed to evaluate the effectiveness and safety of everolimus in treating seizures associated with focal cortical dysplasia type 2 (FCD 2). A prospective, crossover, placebo-controlled clinical trial (ClinicalTrials.gov: NCT03198949) enrolled patients aged 4-40 years pathologically confirmed FCD a history ≥3 per month for two out 3 months prior screening. The included 4-week baseline phase, 12-week core phases, 29-week extension phase. Patients received or placebo blinded manner...
Purpose: Predicting neurologic prognosis in pediatric patients recovered after cardiac arrest is more difficult than adults. This study hypothesized that a combination model of early electroencephalography, brain computed tomography (CT), and laboratory findings improve prediction performance outcome arrest. Methods: We retrospectively analyzed the medical records resuscitated non-traumatic Clinical features, gray matter to white attenuation ratio on CT, were analyzed. The primary was based...
Hearing loss affects more than 27 million people in mainland China. It would be helpful to develop a portable and self-testing audiometer for the timely detection of hearing so that optimal clinical therapeutic schedule can determined.The objective this study was software-based system.The system consisted notebook computer, an external sound card, pair 10-Ω insert earphones. The could used test thresholds by individuals themselves interactive manner using software. reliability validity at...
We report the case of a 5-year-old male patient with multiple aseptic splenic abscesses associated Behçet's disease. The visited Gachon University Gil Hospital fever, abdominal pain, and acute watery bloody diarrhea, reported 2-year history chronic pain intermittent diarrhea. He was treated antibiotics at local clinic for fever cervical lymph node swelling. Additionally, he had recurrent stomatitis. A colonoscopy showed well-demarcated ulcerations throughout colon, computed tomography...
Electroencephalogram (EEG) is an important diagnostic test that physicians use to record brain activity and detect seizures by monitoring the signals. There have been several attempts abnormalities in EEG signals with modern deep learning models reduce clinical burden. However, they cannot be fairly compared against each other as were tested distinct experimental settings. Also, some of them are not trained real-time seizure detection tasks, making it hard for on-device applications....
Abstract This study investigated the utility of artificial intelligence in predicting disease progression. We analysed 194 patients with COVID-19 confirmed by reverse transcription polymerase chain reaction. Among them, 31 had oxygen therapy administered after admission. To assess prediction progression, we used three machine learning models employing clinical features (patient’s background, laboratory data, and symptoms), one deep model computed tomography (CT) images, multimodal a...
For hours-ahead assessment of power systems with a high penetration level renewable generation, large number uncertain scenarios should be checked to ensure the frequency security system after severe disturbance following HVDC blocking. In this situation, full time-domain simulation is unsuitable as result heavy calculation burden. To fulfill quick security, online framework based on deep learning proposed in paper. The Deep Belief Network (DBN) method used establish framework. sample...
Purpose: Coronavirus disease 2019 (COVID-19) causes various neurological symptoms in children, as well respiratory symptoms, and the number of reported cases is increasing with spread severe acute syndrome coronavirus 2 (SARS-CoV-2) variants. This study aimed to investigate incidence pediatric patients hospitalized COVID-19.Methods: We retrospectively analyzed medical records under age 18 diagnosed COVID-19 admitted National Health Insurance Service Ilsan Hospital using real-time reverse...