A5069062337- Gut microbiota and health
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Inflammatory Bowel Disease
- Diet and metabolism studies
- Oral microbiology and periodontitis research
- Food composition and properties
- Clinical Nutrition and Gastroenterology
- Enzyme Production and Characterization
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Bacterial biofilms and quorum sensing
- Infant Nutrition and Health
- Eosinophilic Esophagitis
- Metabolomics and Mass Spectrometry Studies
- Polysaccharides and Plant Cell Walls
- Wastewater Treatment and Nitrogen Removal
- Polyamine Metabolism and Applications
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
Ninewells Hospital
2007-2021
University of Dundee
2006-2015
Leicester General Hospital
2008
University of Nottingham
2008
Kraft Heinz (United Kingdom)
2008
Scottish Government
2008
Chief Scientist Office
2008
Microbiology Society
2004
Medical Research Council
1990-1998
Unité de Nutrition Humaine
1997
In November 2008, a group of scientists met at the 6th Meeting International Scientific Association Probiotics and Prebiotics (ISAPP) in London, Ontario, Canada, to discuss functionality prebiotics. As result this, it was concluded that prebiotic field is currently dominated by gastrointestinal events. However, future, may be case other mixed microbial ecosystems modulated approach, such as oral cavity, skin urogenital tract. Therefore, decision taken build upon current status define niche...
ABSTRACT The colonic microbiota mediates many cellular and molecular events in the host that are important to health. These processes can be affected elderly, because some individuals, composition metabolic activities of change with age. Detailed characterizations major groups fecal bacteria healthy young adults, elderly people, hospitalized patients receiving antibiotics were made this study, together measurements their activities, by analysis organic acid ammonia concentrations. results...
Recognizing the possible beneficial effect of prebiotics in food, Food and Agriculture Organization United Nations (FAO) convened a Technical meeting to start work on evaluation functional health properties prebiotics. A group international experts agreed guidelines, recommended criteria, methodology for conducting systematic approach leading its safe use food. It was that full expert consultation be under auspices FAO. This provides governments, industry, consumers with scientific advice...
The colonic epithelium provides an interface between the host and micro-organisms colonising gastrointestinal tract. Molecular recognition of bacteria is facilitated through Toll-like receptors (TLR). expresses relatively high levels mRNA for TLR3 less TLR2 -4. Little known expression patterns mode induction these pattern in human colon. aim this study was to investigate their localization gut epithelial cell lines by mucosal bacteria. -4 were expressed only crypt cells, lost as cells...
ABSTRACT The human large intestine is covered with a protective mucus coating, which heavily colonized by complex bacterial populations that are distinct from those in the gut lumen. Little known of composition and metabolic activities these biofilms, although they likely to play an important role breakdown. aims this study were determine how intestinal bacteria colonize physiologic enzymatic factors involved destruction glycoprotein. Colonization mucin gels fecal was studied vitro, using...
Aliment Pharmacol Ther 2010; 32: 872–883 Summary Background Crohn’s disease is an inflammatory illness in which the immune response against gut microorganisms believed to drive abnormal response. Consequently, modification of mucosal bacterial communities, and effects they elicit, might be used modify state. Aim To investigate synbiotic consumption on processes patients with Crohn's disease. Methods A randomized, double‐blind placebo‐controlled trial was conducted involving 35 active...
ABSTRACT Little is known about bacterial communities that colonize mucosal surfaces in the human gastrointestinal tract, but they are believed to play an important role host physiology. The objectives of this study were investigate compositions these populations distal small bowel and colon. Healthy tissue from either terminal ileum ( n = 6) or ascending 8), transverse descending colon 4) 26 patients (age, 68.5 ± 1.2 years [mean standard deviation]) undergoing emergency resection large was...
Summary Barrett's oesophagus ( BO ) and gastro‐oesophageal reflux disease GERD are precursors of oesophageal adenocarcinoma OAC ). There is an biofilm, which changes in disease, but its role aetiopathogenesis remains unclear. Aim To define the microbiota patients with , compared controls to investigate mucosal responses related microbiota. Methods Cultural analysis identified dominant bacterial species from a subset each group. Based on this, molecular techniques were used cohort. Host...
Bacteria growing in the human large intestine live intimate association with host and play an important role digestive processes, gut physiology, metabolism. Fecal bacteria have been investigated extensively, but few studies done on biofilms that form wastes bowel. The aims of this investigation were to investigate composition metabolic activities bacterial communities colonize surfaces food residues fecal material, respect their fermentation complex carbohydrates. Fresh stools obtained from...
Barrett's esophagus (BE) is a complication of chronic gastroesophageal reflux disease, in which patients are at greatly increased risk esophageal dysplasia and adenocarcinoma. Over the past 2 decades, there has been an increase incidence both BE adenocarcinoma; however, involvement microorganisms uncertain. The aim this study was to characterize microbial communities aspirate specimens on distal mucosal samples from with BE.Biopsy were obtained by endoscopic examination 7 control subjects...
Background Ageing can result in major changes the composition and metabolic activities of bacterial populations large gut an impaired immune system. Aim To investigate effects synbiotic consumption on colonic microbiota, function health status older people. Methods A randomised, double-blind placebo-controlled, 4-week crossover study was carried out, involving 43 volunteers, using a comprising probiotic Bifidobacterium longum inulin-based prebiotic Synergy 1 (SudZucker, Mannheim, Germany)....
ABSTRACT In humans, nonstarch polysaccharides (NSP), such as arabinoxylans (AX), are not digested in the upper gut and provide fermentable carbon sources for bacteria growing large bowel. Despite ubiquity of AX nature, microbiologic physiologic consequences digestion poorly understood. this study, we investigated breakdown ferulic acid-cross-linked (AXF) non-cross-linked children's intestinal microbiotas, using starch a readily polysaccharide comparative purposes. The experiments were...
The etiology of ulcerative colitis (UC) is unknown, but evidence links it to bacteria belonging the normal colonic microbiota. aims this study were characterize colonizing rectal epithelium, and investigate whether significant differences existed in UC. Rectal biopsy specimens obtained via endoscopy from 9 patients with active 10 without inflammatory bowel disease. Complex bacterial communities colonized mucosa all subjects. Overall, 72 taxa (18 genera) detected. Twenty species common both...
Real-time PCR and northern hybridisations were used to quantify bacterial populations in the large gut of infants. primers for rapid, sensitive, high throughput detection bifidobacteria, bacteroides, sulphate-reducing bacteria Enterococcus faecalis, based on analysis 16S rRNA genes used. Bacterial analysed faeces from 40 infants aged 0-6, 7-12 13-24 months. The effects breast versus bottle feeding was also investigated. indicated that bacteroides desulfovibrio numbers increased markedly...