A5023649568- Forensic Anthropology and Bioarchaeology Studies
- Dental Radiography and Imaging
- Paleopathology and ancient diseases
- Autopsy Techniques and Outcomes
- Forensic and Genetic Research
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Lung Cancer Treatments and Mutations
- Dental Education, Practice, Research
- Medical Malpractice and Liability Issues
- Colorectal Cancer Treatments and Studies
- Restraint-Related Deaths
- Dental Research and COVID-19
- Child Abuse and Trauma
- Ubiquitin and proteasome pathways
- Prostate Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Management, Economics, and Public Policy
- HER2/EGFR in Cancer Research
- Child Abuse and Related Trauma
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Female Genital Mutilation/Cutting Issues
- Cancer, Hypoxia, and Metabolism
University of Bari Aldo Moro
2013-2024
Azienda Ospedaliera Universitaria Integrata Verona
2024
Boehringer Ingelheim (Austria)
2020-2024
Bayer (Germany)
2016-2020
Weatherford College
2020
University College London
2013-2015
Cancer Research UK
2015
CRUK Lung Cancer Centre of Excellence
2013
Ospedale Santa Chiara
1995
National University of Rosario
1970
The antibody cetuximab, targeting epidermal growth factor receptor (EGFR), is used to treat metastatic colorectal cancer (mCRC). Clinical trials suggest reduced benefit from the combination of cetuximab with oxaliplatin. aim this study was investigate potential negative interactions between and Thiazolyl blue tetrazolium bromide (MTT) assay Calcusyn software were characterize drug interactions. Reactive oxygen species (ROS) measured by flow cytometry real-time polymerase chain reaction...
// Valeria Santoro 1 , * Ilya Kovalenko 2 Kim Vriens 3 4 Stefan Christen Andreas Bernthaler Andrea Haegebarth Sarah-Maria Fendt and Sven Christian Bayer AG, Drug Discovery, Berlin 13353, Germany Current address: University of Michigan, Cancer Center, Ann Arbor, MI 48108, USA Laboratory Cellular Metabolism Metabolic Regulation, VIB Center for Biology, VIB, Leuven 3000, Belgium Department Oncology, KU Institute (LKI), These authors contributed equally to this work Correspondence to: Christian,...
Pink teeth have most often been observed in victims of drowning but also reported subjects who died suddenly and unnaturally. There is general agreement that there no obvious connection between the occurrence pink cause death, condition surroundings (especially humidity) must certainly play an important role development pink-tooth phenomenon. The frequency distribution postmortem coloration studied among a representative sample 52 cadavers. All bodies were single shipwreck occurred on March...
Dental caries was identified as the single most common chronic childhood disease; its prevention should be a priority for dentists. With aim of describing correlation between early (ECC) and phenomenon child neglect, questionnaire which recorded socio-economic dental service use data provided to randomly chosen sample parents at three pediatric health centers in Bari (Italy).In order evaluate association among risk factors ECC, contingency tables were created value Odds Ratio (OR)...
Abstract Alterations in KRAS are a main cancer driver. Amplifications of the wild-type (wt) allele account for ~7% all KRAS-driven cancers and frequent gastric (~5%), esophageal (~13%) gastroesophageal junction (~12%). KRASG12V mutations ~28% pancreatic cancers, 9% colorectal 6% lung adenocarcinoma. There is an urgent medical need to identify targeted therapies these alterations. Herein, we describe BI 3706674, novel, potent orally bioavailable small molecule inhibitor oncogene clinical...
Accurate timing of the eruption first and permanent teeth is an important parameter in forensic odontology to establish age dead or live individuals. Determination adulthood may determine, for example, whether individual convicted a crime sentenced as adult incarcerated state penal institution juvenile sent camp. At present, there large immigrant population Italy, young foreign criminals sometimes have false passports bearing later birth date, with aim evading punishment. In such...
The Authors describe two cases of alleged malpractice due to overfilling. aim this article is underline some medico-legal aspects regarding the quantity extruded material which may be considered acceptable and consequent damage patient. Two are presented here: In first case, dentist's liability clear excessive extrusion endodontic beyond apical region combined with incomplete obturation canals. second case however, because different dentists were involved, establishing connection causality...
To resolve cases involving unidentified cadavers, the study of polymorphic DNA markers old bones is an invaluable but often challenging tool used in forensic genetics. Some difficulties encountered involve limited quantity endogenous DNA, its subsequent degradation (a result elapsed time, environmental conditions, and microorganisms that develop during postmortem phase), coextraction substances inhibit amplification reactions. For these reasons, it necessary to direct research toward...
Abstract Alterations of KRAS are found in approximately one seven all human cancers, making the main oncogenic drivers cancer. Gain-of-function missense mutations ~90% pancreatic cancer, ~40% colorectal cancer and ~30% lung adenocarcinoma. In addition, focal high-level amplification wild-type (wt) allele, an alternative means activating this oncoprotein, is observed ~7% cancers lacks effective targeted therapies. Thus, there urgent need to identify therapies address KRAS-driven tumors....
Age estimation of nonliving subjects plays a very important role in identifying human remains. When adult remains are question, this process becomes even more complex. Among the numerous dental methods that exist for adults aging, evaluation root translucency is one most useful. This study studies correlation between age and by investigating monoradicular teeth affected pathological processes using equations proposed Lamendin, Prince & Ubelaker from Singhal et al. The average values...
The aim of this study was to work out a biometric method for personal identification by comparing simulated antemortem and postmortem digital radiographs unrestored teeth. Intra-oral the inferior right first molar, without restorations, were acquired at two different times in 70 subjects using standardized technique followed morphometric analysis. program automatically supplied values absolute distances, relative shape factors, moments, perimeter values, areas triangles, which obtained...
Coronavirus Disease 2019 (COVID-19) pandemic had an overwhelming impact on healthcare worldwide. Outstandingly, the aftermath neoplastic patients is still largely unknown, and only isolated cases of COVID-19 during radiotherapy have been published. We will report two-months experience our Department, set in Lombardy "red-zone". Data 402 cancer undergoing active treatment from February 24 to April 24, 2020 were retrospectively reviewed; several indicators Department functioning also analyzed....