A5008610706- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
Agency for Science, Technology and Research
2023
National Skin Centre
2020
The mammalian epidermis undergoes constant renewal, replenished by a pool of stem cells and terminal differentiation their progeny. This is accompanied changes in gene expression morphology that are orchestrated, part, epigenetic modifiers. Here, we define the role histone acetyltransferase KAT2A epidermal homeostasis provide comparative analysis reveals key functional divergence with its paralog KAT2B. In contrast to reported function KAT2B differentiation, supports undifferentiated state...
Post-translational modifications on nucleosomal histones represent a key epigenetic regulatory mechanism to mediate the complex gene expression, DNA replication, and cell cycle changes that occur in embryonic cells undergoing lineage specification, maturation, differentiation during development. Here, we investigated dynamics of 13 histone marks epidermal at three distinct stages skin development identified significant corresponded with maturation proliferative basal terminally...