A5002416446- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Renal and related cancers
- Reproductive Health and Technologies
- Diet and metabolism studies
- Ovarian function and disorders
- Genetic Syndromes and Imprinting
- Reproductive System and Pregnancy
- Genomic variations and chromosomal abnormalities
- Obesity, Physical Activity, Diet
- Chromosomal and Genetic Variations
- Food composition and properties
- Phytoestrogen effects and research
- Nutritional Studies and Diet
- Fetal and Pediatric Neurological Disorders
Hospital Universitario Dexeus
2017-2024
Reproductive Science Center
2024
Hospital Universitario Son Espases
2018
A retrospective cohort study was performed to examine whether, in artificial endometrial preparation for frozen embryo transfer (FET) cycles, progesterone (P) levels the day prior of euploid embryos have an impact on pregnancy outcomes. In a private university clinic, 244 FETs between January 2016 and June 2017 were analyzed. Endometrial achieved with estradiol valerate vaginal micronized progesterone. Serum P measured. multivariable analysis assess relationship serum level outcomes...
Abstract STUDY QUESTION Does an individualised luteal phase support (iLPS), according to serum progesterone (P4) level the day prior euploid frozen embryo transfer (FET), improve pregnancy outcomes when started on previous transfer? SUMMARY ANSWER Patients with low P4 FET can benefit from addition of daily subcutaneous injections (Psc), FET, and achieve similar reproductive compared those initial adequate levels. WHAT IS KNOWN ALREADY The ratio between FET/IVF has spectacularly increased in...
In oocytes of advanced maternal age (AMA) women, what are the mechanisms leading to aneuploidy and is association with embryo development?Known chromosome segregation errors such as precocious separation sister chromatids explained 90.4% abnormal copy numbers in polar bodies (PBs), underlying impaired development.Meiotic chromosomal aneuploidies correlate AMA (>35 years) can affect over half this group. This underlies rationale for PB biopsy a form early preimplantation genetic testing...
Summary Shortly after the implementation of comprehensive chromosome screening (CCS) techniques for preimplantation genetic testing aneuploidies (PGT-A), discussion about transition from day 3 to blastocyst stage biopsy was initiated. Trophectoderm with CCS is meant overcome limitations cleavage-stage and single-cell analysis. The aim this study assess results obtained in our PGT-A programme new strategy. Comparisons between 179 cycles (D+3) fresh embryo transfer, 204 trophectoderm deferred...
The transition in biopsy timing from blastomere to trophectoderm has led a remarkable decrease the percentage of undiagnosed blastocysts. However, patients with few or no euploid blastocysts can be affected by this residual diagnosis failure. aim study is assess whether blastocyst rebiopsy and revitrification an efficient safe procedure applied cases results after analysis. Fifty-three agreed warming 61 perform second PGT-A aCGH. Only 75.4% survived, reexpanded, could rebiopsied. After...
This study aims to increase the knowledge about monopronucleated ICSI-derived blastocysts, analyzing trophectoderm biopsies by aCGH and FISH evaluate their chromosome constitution.Fifteen blastocysts were studied. Double biopsy was performed analyzed aCGH. The classified according constitution. Disagreements between two techniques assessed.Results obtained after analyses showed following: 20% (3/15) 60% (9/15) diploid females, respectively; 26.7% (4/15) males, 53.3% (8/15) 13.3% (2/15)...
ABSTRACT Many chromosome abnormalities are commonly observed and can lead to early pregnancy loss, miscarriage, or the birth of children with chromosomal defects. Such considered a major factor in low rate after assisted reproductive technology natural conception. Preimplantation genetic testing for aneuploidy (PGT-A) aims minimize transfer aneuploid embryos. Embryonic aneuploidies arising from errors meiosis have an incidence approximately 25% embryos women younger than 35 years, more half...
Abstract Study question Is a fully-automated system faster and reliable sperm counting method? Summary answer A is tool that significantly reduces time spent for semen evaluation. What known already The emergence of automated tools in our everyday life reality. Fully-automated systems the evaluation seminal samples are available andrology laboratories. expected advantages such analysers would be higher reliability reproducibility results, with lower inter intra-individual variability....
To assess patients' and embryonic characteristics that may have an influence on the decision to transfer a mosaic embryo.Single centre retrospective cohort study including 1247 PGT-A cycles. Demographic clinical factors associated with embryo were studied. Female age, number of previous cycles, availability euploid embryos, history miscarriages parity as well percentage mosaicism, type anomaly chromosome risk studied in relation decision-making. Outcomes after assessed.To date, 7.9% cycles...
Abstract Study question In oocytes of advanced maternal age (AMA) women, what is the association aneuploidy with embryo development and are mechanisms leading to aneuploidy? Summary answer We confirmed precocious separation sister chromatids as main cause aneuploidy. Known chromosome segregation errors explained 90.4% observed abnormal copy numbers in polar bodies. What known already Meiotic chromosomal aneuploidies correlate AMA (>35 years), can affect over half this group. This...