A5043110324- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
King Abdulaziz University
2021-2025
University of Manchester
2021
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) in brain. The prevalence increasing expected to reach 141 million cases 2050. Despite risk factors associated with disease, there no known causative agent for AD. Clinical trials many drugs have failed over years, therapeutic has been approved There evidence that pathogens are found brains AD patients controls, such as human herpes simplex virus-1 (HSV-1). Given lack a...
Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing infections ranging from skin disorders to severe conditions like infective endocarditis. Its evolving resistance, including resistance β-lactams and last-resort antibiotics, such as vancomycin, daptomycin, linezolid, necessitates alternative therapies. This study investigates the synergistic efficacy of vancomycin 3-hydrazinoquinoxaline-2-thiol (3HL) against 23 clinical MRSA isolates. Susceptibility testing was...