A5050189693- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Protein Structure and Dynamics
- Green IT and Sustainability
- Hemoglobinopathies and Related Disorders
- Mobile Crowdsensing and Crowdsourcing
- HIV/AIDS Research and Interventions
- RNA Research and Splicing
- Hemoglobin structure and function
- Scientific Computing and Data Management
Health Data Research UK
2023
Columbia University
1994-2003
Howard Hughes Medical Institute
1994-2000
HIV-1 reverse transcriptase (RT) catalyzes the conversion of genomic RNA into cDNA. The enzyme is a heterodimer p66 and p51 subunits, dimerization these subunits required for optimal activity. To analyze this process at genetic level, we developed constructs that permit detection interaction between in yeast two-hybrid system. Genetic analysis RT subdomains heterodimerization revealed fingers palm were dispensable interaction. However, as little 26-amino acid deletion C terminus prevented...
Abstract The globin family of protein structures was the first for which it recognized that tertiary structure can be highly conserved even when primary sequences have diverged to a virtually undetectable level similarity. This principle structural inertia in molecular evolution is now evident many other families. We performed systematic comparison and 6 representative hemoglobin subunits as diverse origin plants, clams, humans. Our analysis based on 97‐residue helical core common all...