A5004609398- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Peripheral Artery Disease Management
- Aortic Disease and Treatment Approaches
- Protease and Inhibitor Mechanisms
- Erythrocyte Function and Pathophysiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac pacing and defibrillation studies
- Angiogenesis and VEGF in Cancer
- Nuclear Structure and Function
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Ultrasound in Clinical Applications
Hainan Medical University
2024-2025
Hainan General Hospital
2024-2025
Saint Louis University Hospital
2022-2025
Washington University in St. Louis
2013-2024
Saint Louis University
2023
Methodist Hospital
2016-2021
Jungheinrich (Germany)
2019
Cardiovascular Research Center
2019
Zero to Three
2017
Houston Methodist
2017
Obesity adversely affects myocardial metabolism, efficiency, and diastolic function. Our objective was to determine whether weight loss can ameliorate obesity-related metabolism efficiency derangements that these improvements directly relate improved function in humans. We studied 30 obese (BMI >30 kg/m2) subjects with positron emission tomography (PET) (myocardial blood flow) echocardiography (structure, function) before after marked from gastric bypass surgery (N = 10) or moderate diet...
Elastin is an important ECM (extracellular matrix) protein in large and small arteries. Vascular smooth muscle cells (SMCs) produce the layered elastic laminae found arteries but synthesize little elastin muscular However, have a well-defined internal lamina (IEL) that separates endothelial (ECs) from SMCs. The extent to which ECs contribute IEL unknown.To use targeted (Eln) deletion mice explore relative contributions of SMCs formation different arteries.We used SMC- EC-specific Cre...
BACKGROUND The use of posttransplant cyclophosphamide (PT‐Cy) has contributed significantly to the success haploidentical hematopoietic cell transplantation (HCT). Furthermore, several studies have shown promising results in human leukocyte antigen–matched setting. However, high‐dose been associated with development cardiomyopathy. There is a paucity data concerning cardiac complications patients undergoing PT‐Cy–based HCT. METHODS A retrospective analysis 176 HCT PT‐Cy was performed....
Thoracic and abdominal aortic aneurysms (TAAs AAAs, respectively) share morphological features but have distinct clinical hereditary characteristics. Studies using bulk RNA comparisons revealed patterns of gene expression in human TAA AAA tissues. However, given the summative nature studies, these findings represent totality without regards to differences cellular composition. Single-cell sequencing provides an opportunity interrogate cell-type-specific transcriptomes. Single cell datasets...
Objective: Using a mouse model of Eln (elastin) insufficiency that spontaneously develops neointima in the ascending aorta, we sought to understand origin and phenotypic heterogeneity smooth muscle cells (SMCs) contributing intimal hyperplasia. We were also interested exploring how vascular adapt absence Eln. Approach Results: used single-cell sequencing together with lineage-specific cell labeling identify neointimal populations noninjury, genetic formation. Inactivating production SMCs...
Background Adults with congenital heart disease (ACHD) have traditionally been viewed as an underinsured population. Whether this is true in the Affordable Care Act era unknown. We determined insurance patterns ACHD patients compared to non-ACHD cardiology population a contemporary cohort. Methods All outpatient visits between July 2016 and February 2017 large referral center United States were reviewed. The primary payer was categorized health maintenance organization (HMO), preferred...
Abstract This study examined the effect of rottlerin on focal adhesion‐mediated cell migration CGTH W‐2 human follicular thyroid carcinoma cells. Rottlerin (10 µM) resulted in decreased adhesion cells to matrix substance, which was correlated with metastatic potential. treatment also a marked reduction Protein levels integrin β1, FAK, and paxillin were by rottlerin. Consistent this, immunostaining vinculin, revealed disassembly adhesions. Disruption actin stress fibers noted, compatible...
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation intact tissue; thus, the functional consequences these predicted lipid-channel interactions within native cellular environments remain elusive. The goal this study to investigate how lipid endothelial Kir2.1 - an inwardly rectifying potassium channel that regulates membrane hyperpolarization contributes vasodilation resistance arteries. First, we show phosphatidylserine (PS) localizes a...