A5073135576- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Essential Oils and Antimicrobial Activity
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Ethnobotanical and Medicinal Plants Studies
- Cancer therapeutics and mechanisms
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Phytase and its Applications
- Cancer Immunotherapy and Biomarkers
- Bioactive Compounds and Antitumor Agents
- Pneumonia and Respiratory Infections
- Biochemical and Structural Characterization
- Venomous Animal Envenomation and Studies
- Phytochemistry and Biological Activities
- Force Microscopy Techniques and Applications
- Streptococcal Infections and Treatments
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Synthesis and biological activity
Woolcock Institute of Medical Research
2021-2023
Garvan Institute of Medical Research
2019-2022
The University of Sydney
2018-2021
Cancer Institute of New South Wales
2020
UNSW Sydney
2020
University of Dhaka
1970-2019
St George Hospital
2018
Centenary Institute
2018
St. George's School
2018
BRAC University
2014
How proteins harness mechanical force to control function is a significant biological question. Here we describe human cell surface receptor that couples ligand binding and trigger chemical event which controls the adhesive properties of receptor. Our studies secreted platelet oxidoreductase, ERp5, have revealed it mediates release fibrinogen from activated αIIbβ3 integrin. Protein show extended integrin renders βI-domain Cys177-Cys184 disulfide bond cleavable by ERp5. Fluid shear...
Significance Antibody affinity rises during immune responses to viruses via antibody gene somatic hypermutation and Darwinian selection of mutated B cells—in a time frame days. The enzyme activation-induced deaminase (AID) initiates by deaminating genomic cytosines. Mutation is exacerbated noncanonical G 1 -phase DNA repair pathways that deploy error-prone polymerases, including Pol η (gene Polh ). In phase, dNTP levels are restricted inhibit viral replication. We derestricted supply in...
High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined relationship between these...
Background & AimsThe early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance precancerous lesions or polyps known. Here, we aimed to determine the impact of Mcc deletion on cellular pathways carcinogenesis associated with mouse proximal colon.MethodsWe generated knockout mice colonic/intestinal epithelial cells (MccΔIEC) whole body (MccΔ/Δ)....
The aim of this study was to characterize keratinolytic bacteria isolated from feather waste. Six isolates were recovered poultry feather- decomposed materials. Isolate Z3 and Z4 showed important degrading activity when grown on basal medium containing 1% native as the only source energy, carbon nitrogen. All Gram positive rod-shaped bacilli. Based microscopic biochemical analysis, identified Bacillus spp. Keratinolytic activities these measured after cultivation raw feathers. Maximum...
Cynodon dactylon (Poacae) is a well known traditional plant used as folk remedy in treatment of many symptoms and diseases like cramps, measles, tumors, wounds, warts, fever rheumatic affections. In this study, the antimicrobial activity crude extract from three different extraction (hot cold aqueous extraction, methanol extraction) was investigated against some gram positive bacteria (Staphylococcus epidermidis, Bacillus cereus) negative (Escherichia coli, Pseudomonas aeroginosa, Salmonella...
MSH3 gene or protein deficiency loss-of-function in colorectal cancer can cause a DNA mismatch repair defect known as "elevated microsatellite alterations at selected tetranucleotide repeats" (EMAST). A high percentage of MSI-H tumors exhibit EMAST, while MSI-L is also linked with EMAST. However, the distribution CpG island methylator phenotype (CIMP) within EMAST spectrum not known. Five repeat and five MSI markers were used to classify 100 sporadic tumours for according number unstable...
Chemotherapy is a mainstay of colorectal cancer treatment, and often involves combination drug regime. CpG island methylator phenotype (CIMP)-positive tumors are potentially more responsive to the topoisomerase-inhibitor irinotecan. The mechanistic basis increased sensitivity CIMP cancers irinotecan poorly understood. Mutated in Colorectal Cancer (MCC) emerging as multifunctional tumor suppressor gene liver cancers, has been implicated responsiveness. Here, we found that undergo MCC loss...
Immunogenicity of a pneumococcal 74 kDa surface protein in the rabbit model was investigated this study. For this, Streptococcus pneumoniae serotype 7F collected and water extraction procedure applied for preparation materials, which used further isolation protein. Rabbits were immunized with sonicated nitrocellulose membrane containing control group rabbits injected same concentration only. The antibody response against evaluated by both ELISA immunoblot assay. Sera from examined high titre...
The Tagetes erecta an extensively used medicinal plant is a small shrub, which grows up to 1–2 mm. present study was aimed investigate the antibacterial activity of this common locally available plant. Antimicrobial three confined densities crude extracts (cold aqueous, hot aqueous and methanol extracts) leaves flowers evaluated by disk diffusion method against seven different pathogenic species gram positive negative bacteria. result indicates that leaf flower part showed broad spectrum...
<p>Figure S1, related to Figure 1: Expression and correlation of CHK1 CIP2A in multiple glioma cohorts. S2, Overall survival mRNA expression PP2A subunits patients. S3, Role CHK1-CIP2A Glioma Stem cell lines. S4, 3: Effect or on GBM cells. S5, 5: Depletion induces senescence S6, 6: Regulation by STAT3.</p>
<p>Figure S1, related to Figure 1: Expression and correlation of CHK1 CIP2A in multiple glioma cohorts. S2, Overall survival mRNA expression PP2A subunits patients. S3, Role CHK1-CIP2A Glioma Stem cell lines. S4, 3: Effect or on GBM cells. S5, 5: Depletion induces senescence S6, 6: Regulation by STAT3.</p>
<div>Abstract<p>High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined...
<div>Abstract<p>High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined...
Surface proteins of Escherichia coli O157:H7, those that are prominent in antigen-antibody reactions among different strains, were found to provide protection against E. O157 challenge mice. Three strains such as O157:H7 NCTC reference strain and two other environmentally isolated have been used this study. New Zealand rabbits immunized with surface immunoblot analysis was performed the all three strains. Immunoblot revealed a 94 kDa protein could be possible candidate for protective...