A5024952572- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Chronic Lymphocytic Leukemia Research
- Zebrafish Biomedical Research Applications
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- MicroRNA in disease regulation
UNSW Sydney
2019-2023
Pancreatic Cancer Action Network
2021
Cancer Institute of New South Wales
2020
University of Technology Sydney
2019
Brigham and Women's Hospital
2017
Harvard University
2017
Glioblastoma (GBM) brain tumor remains among the most lethal and incurable human diseases. Oncogenic microRNA-10b (miR-10b) is strongly universally upregulated in GBM, its inhibition by antisense oligonucleotides (ASOs) reduces growth of heterogeneous glioma cells; therefore, miR-10b represents a unique therapeutic target for GBM. Here we explored effects gene editing on Using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system, investigated cultured cells,...
High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined relationship between these...
Abstract The BloodChIP Xtra database (http://bloodchipXtra.vafaeelab.com/) facilitates genome-wide exploration and visualization of transcription factor (TF) occupancy chromatin configuration in rare primary human hematopoietic stem (HSC-MPP) progenitor (CMP, GMP, MEP) cells acute myeloid leukemia (AML) cell lines (KG-1, ME-1, Kasumi1, TSU-1621-MT), along with accessibility gene expression data from these patient AMLs. features significantly more datasets than our earlier (two types two...
ABSTRACT Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These are disrupted during leukemic transformation but knowledge of the regulatory changes underpinning this process is elusive. We hypothesised that identifying core networks healthy could provide insights into network alterations perturb state transitions. A heptad transcription factors (LYL1, TAL1, LMO2, FLI1, ERG, GATA2, RUNX1) bind...
<p>Figure S1, related to Figure 1: Expression and correlation of CHK1 CIP2A in multiple glioma cohorts. S2, Overall survival mRNA expression PP2A subunits patients. S3, Role CHK1-CIP2A Glioma Stem cell lines. S4, 3: Effect or on GBM cells. S5, 5: Depletion induces senescence S6, 6: Regulation by STAT3.</p>
<p>Figure S1, related to Figure 1: Expression and correlation of CHK1 CIP2A in multiple glioma cohorts. S2, Overall survival mRNA expression PP2A subunits patients. S3, Role CHK1-CIP2A Glioma Stem cell lines. S4, 3: Effect or on GBM cells. S5, 5: Depletion induces senescence S6, 6: Regulation by STAT3.</p>
<div>Abstract<p>High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined...
<div>Abstract<p>High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and tissue sections. However, whether constitutive activation overexpression CHK1 GBM plays a functional role tumorigenesis or prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels oncogene cancerous inhibitor phosphatase 2A (CIP2A), known target high-CHK1 activity, examined...