A5006465844- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Sedative Agents
- Ultrasound and Hyperthermia Applications
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- S100 Proteins and Annexins
- Neurogenetic and Muscular Disorders Research
- Electroconvulsive Therapy Studies
- Ultrasound Imaging and Elastography
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Epilepsy research and treatment
- Nicotinic Acetylcholine Receptors Study
- Myasthenia Gravis and Thymoma
- Abdominal Trauma and Injuries
- Ion Transport and Channel Regulation
- Trauma and Emergency Care Studies
- RNA regulation and disease
- Meta-analysis and systematic reviews
- Neurological and metabolic disorders
- Nuclear Structure and Function
University of Würzburg
2012-2024
Universitätsklinikum Würzburg
2013-2023
University Hospital Leipzig
2019
University of Toronto
2019
Leipzig University
2019
Toronto General Hospital
2019
Klinik und Poliklinik für Urologie
2009-2019
American Society of Anesthesiologists
2012
Children's Clinical University Hospital
1980
Heidelberg University
1980
Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these patients. Here, we present the European Neuromuscular Centre (ENMC) consensus statement on anaesthesia in patients disorders as formulated during 259th ENMC Workshop Anaesthesia Disorders.International experts field (paediatric) anaesthesia, neurology, and genetics were invited participate...
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder which characterized by life-threatening metabolic crises during general anesthesia. Classical triggering substances are volatile anesthetics and succinylcholine (SCh). The molecular basis of MH excessive release Ca2+ in skeletal muscle principally mutated ryanodine receptor type 1 (RyR1). To identify factors explaining the variable phenotypic presentation complex pathomechanism, we analyzed proven events terms clinical course,...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Malignant hyperthermia (MH) is a potentially lethal disorder triggered by certain anesthetics. Mutations in the ryanodine receptor 1 (RYR1) gene account for half of MH cases. Discordance between low incidence and high prevalence mutations has been attributed to incomplete penetrance, which not quantified yet. The authors aimed examine penetrance MH-diagnostic RYR1 likelihood mutation...
Malignant hyperthermia (MH), a metabolic myopathy triggered by volatile anesthetics and depolarizing muscle relaxants, is potentially lethal complication of general anesthesia in susceptible patients. The implementation modern inhalation that research indicates as less potent trigger substances the recommended limitations succinylcholine use, suggests there may be considerable decline fulminant MH cases. In presented study, authors analyzed suspected episodes during patients were referred to...
While the impact of volatile anaesthetics to induce malignant hyperthermia (MH) is abundantly clear, role succinylcholine still remains controversial. To evaluate influence on porcine MH events, authors investigated hemodynamic and metabolic responses in susceptible (MHS) non-susceptible (MHN) swine following either or halothane application alone a combination both substances. With approval local animal care committee 27 MHS 30 MHN pigs were anaesthetized mechanically ventilated. Fiberoptic...
Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test suitable diagnose MH susceptibility among patients hyperCKemia.Thirty-nine participants were included: 10 susceptible (MHS); 21 non-susceptible (MHN); and 8 had MHN persistent hyperCKemia >500 U/L. Microdialysis probes inserted into the vastus lateralis muscle, halothane or caffeine was injected via an...
Die maligne Hyperthermie ist eine seltene, aber lebensbedrohliche Komplikation der Allgemeinanästhesie. Eine sehr variable Symptomatik erschwert die Diagnose. Für erfolgreiche Behandlung müssen zeitnah Maßnahmen eingeleitet werden; abhängig vom klinischen Erscheinungsbild kann differenzierte Therapie notwendig werden. den vorliegenden Beitrag wurden aktuellen Therapieempfehlungen begutachtet und in einer konkreten SOP zusammengefasst, Ihnen als Grundlage für Erarbeitung eigener...
Background Fulminant malignant hyperthermia (MH) is a rare emergency that should be known to every medical professional although practical exposure rarity even for experienced anesthesiologists. The vast majority of documented MH cases occurred during general anesthesia in the operating room following application volatile anesthetics and/or depolarizing muscle relaxants. With increasing utilization anesthetic conserving device AnaConDa sedation intensive care patients, who could benefit from...
In Brief BACKGROUND: The 5-HT3-receptor antagonist ondansetron, commonly used to treat nausea and vomiting, was suspected of triggering malignant hyperthermia (MH) when a 5-year-old boy died after receiving therapeutic dose ondansetron. To evaluate possible influence ondansetron on the onset MH, we investigated its effect muscle specimens MH-susceptible (MHS) MH-nonsusceptible (MHN) individuals in vitro. METHODS: Muscle bundles 6 MHS 10 MHN patients were incubated tissue bath with at...
Malignant hyperthermia (MH) is a rare, heterogenic syndrome leading to potentially life-threatening skeletal muscle hypermetabolism following exposure inhalational anesthetics and succinylcholine. In more than 50% of affected individuals pathogenic variant in the RYR1 gene coding for sarcoplasmic reticulum calcium channel responsible underlying pathology uncontrolled liberation. While genetic prevalence MH as high 1 : 2750, incidence clinical reactions considerably lower, suggesting dominant...
Background Sevoflurane is a known triggering agent of malignant hyperthermia ( MH ). The present study analyzed different effects sevoflurane on skeletal muscle susceptible and nonsusceptible individuals in vitro compared the results to standardized test protocol with halothane caffeine. A potential influence ryanodine receptor type 1 RyR1 ) mutation was investigated. Methods Muscle bundles 24 ‐susceptible patients or without an mutation, 35 ‐nonsusceptible 10 ‐equivocal were exposed either...
The calcium sensitizer levosimendan is increasingly used to improve hemodynamics in patients with acutely decompensated heart failure. By binding cardiac troponin C the conformation of calcium-troponin complex stabilized, which leads acceleration actin-myosin crossbrigde formation and increased force generating capacity muscle fibers. Besides indications failure, beneficial effects skeletal disorders are currently evaluated. aim this study was investigate differential on pigs without...
Emery-Dreifuss muscular dystrophy (EDMD) is a hereditary neuromuscular disorder characterized by slowly progressive muscle weakness, early contractures, and dilated cardiomyopathy. We reported an uneventful general anaesthesia using total intravenous (TIVA) for cardiac transplantation in 19-year-old woman suffering from EDMD. In vitro contracture test results of two pectoralis major bundles the patient suggest that exposition to triggering agents does not induce pathological sarcoplasmic...
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle presenting as hypermetabolic response to potent volatile anesthetics such sevoflurane, desflurane, isoflurane and the depolarizing relaxant succinylcholine. Following introduction hydantoin derivative dantrolene, previously high mortality fulminant MH episodes could be reduced from > 80% less than 10%. For treatment an initial intravenous bolus 2.5 mg/kg dantrolene based on actual body weight should applied. If...
Malignant hyperthermia is a rare but life-threatening complication of general anesthesia in predisposed patients usually triggered by potent inhalation anesthetics and/or the depolarizing muscle relaxant succinylcholine. The authors present case delayed sevoflurane-induced malignant 21-year-old male patient that was sufficiently treated discontinuation trigger agent application and dantrolene infusion. After surviving an MH episode diagnostic procedures are indicated to increase safety. In...