A5067659571- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Circadian rhythm and melatonin
- Lattice Boltzmann Simulation Studies
- Diabetes Treatment and Management
- Organ Donation and Transplantation
- Renin-Angiotensin System Studies
- Nonlinear Dynamics and Pattern Formation
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
- Hemoglobin structure and function
- Advanced Thermodynamics and Statistical Mechanics
- Urinary Bladder and Prostate Research
- Neuroscience of respiration and sleep
- Hormonal Regulation and Hypertension
- Fluid Dynamics and Turbulent Flows
- Renal and related cancers
- Pancreatic function and diabetes
- Magnesium in Health and Disease
University of Waterloo
2018-2025
Applied Mathematics (United States)
2022-2024
Duke University
2010-2019
New Jersey Institute of Technology
2016
Crescent University
2009-2011
University of North Carolina at Chapel Hill
2002-2004
NSF National Center for Atmospheric Research
2002
University of Toronto
2002
Diabetes increases the reabsorption of Na(+) (TNa) and glucose via sodium-glucose cotransporter SGLT2 in early proximal tubule (S1-S2 segments) renal cortex. inhibitors enhance excretion lower hyperglycemia diabetes. We aimed to investigate how diabetes inhibition affect TNa sodium transport-dependent oxygen consumption [Formula: see text] along whole nephron. To do so, we developed a mathematical model water solute transport from Bowman space papillary tip superficial nephron rat kidney....
The objective of this study was to investigate how physiological, pharmacological, and pathological conditions that alter sodium reabsorption (TNa) in the proximal tubule affect oxygen consumption (QO2 ) Na(+) transport efficiency (TNa/QO2 ). To do so, we expanded a mathematical model solute rat kidney. represents compliant S1, S2, S3 segments accounts for their specific apical basolateral transporters. Sodium is reabsorbed transcellularly, via Na(+)/H(+) exchangers (NHE) Na(+)-glucose...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors enhance urinary glucose, Na+ and fluid excretion, lower hyperglycemia in diabetes by targeting glucose reabsorption along the proximal convoluted tubule. A goal of this study was to predict effects SGLT2 diabetic nondiabetic patients with chronic kidney disease. To that end, we employed computational rat models explore how inhibition affects renal solute transport metabolism when nephron populations are normal or reduced. Model simulations...
Abstract Background Cells adapt their metabolism and activities in response to signals from surroundings, this ability is essential for survival the face of perturbations. In tissues a deficit these mechanisms commonly associated with cellular aging diseases, such as cardiovascular disease, cancer, immune system decline, neurological pathologies. Several proteins have been identified being able respond directly energy, nutrient, growth factor levels stress stimuli order mediate adaptations...
The goal of this study was to develop a mathematical model simulate the actions drugs that target SARS-CoV-2 virus infection. To accomplish goal, we have developed describes control infection by innate and adaptive immune components. Invasion triggers immunity, whereby interferon renders some cells resistant infection, infected are removed effector cells. response is represented plasma virus-specific antibodies. parameterized then validated against viral load measurements collected in...
Nutrient acquisition and metabolism pathways are altered in cancer cells to meet bioenergetic biosynthetic demands. A major regulator of cellular energy homeostasis, normal cells, is AMP-activated protein kinase (AMPK). AMPK influences cell growth via its modulation the mechanistic target Rapamycin (mTOR) pathway, specifically, by inhibiting mTOR complex mTORC1, which facilitates proliferation, activating mTORC2 survival. Given conflicting roles, effects activation can be counter intuitive....
Abstract Excess nutrient inputs from agricultural and urban sources have accelerated eutrophication increased the incidence of algal blooms in Great Lakes Basin (GLB). Lake basin management to address these threats relies on understanding key drivers pollution. Here, we use a random forest machine learning model leverage information 202 monitored streams GLB predict seasonal annual flow‐weighted concentrations nitrogen phosphorus, as well ratios across GLB. Land (agricultural land) land...
Hypertension, a leading cause of cardiovascular disease and premature death, remains incompletely understood despite extensive research. Indeed, even though numerous drugs are available, achieving adequate blood pressure control challenge, prompting recent interest in artificial intelligence. To promote the use machine learning medicine, this review provides brief introduction to reviews its notable applications hypertension management research, such as diagnosis prognosis, treatment...
Background: Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve glycemia and reduce insulin requirements in type 1 (T1D) 2 (T2D) diabetes. While SGLT2 lower cardiovascular disease (CVD) end-stage kidney (ESKD) risk T2D, no dedicated cardiorenal outcome trials T1D have been done to date. Using validated prediction models, this study evaluated the effect of inhibition on estimated CVD ESKD a cohort. Methods: Demographics, medical history, biomarkers were extracted from 1,473...
Summary The ability of mammals to produce urine hyperosmotic plasma requires the generation a gradient increasing osmolality along medulla from corticomedullary junction papilla tip. Countercurrent multiplication apparently establishes this in outer medulla, where there is substantial transepithelial reabsorption NaCl water-impermeable thick ascending limbs loops Henle. However, process does not establish much steeper osmotic inner are no Henle and thin lack active transport or any other...
The goal of this study was to investigate water and solute transport, with a focus on sodium transport (TNa) metabolism along individual nephron segments under differing physiological pathophysiological conditions. To accomplish goal, we developed computational model oxygen consumption (QO2 ) different populations rat kidney. represents detailed epithelial paracellular processes both the superficial juxtamedullary nephrons, loop Henle each extending depths inner medulla. We used assess how...
The establishment of cell polarity involves positive-feedback mechanisms that concentrate regulators, including the conserved GTPase Cdc42p, at “front” polarized cell. Previous studies in yeast suggested presence two parallel loops, one operating as a diffusion-based system, and other involving actin-directed trafficking Cdc42p on vesicles. F-actin (and hence directed vesicle traffic) speeds fluorescence recovery after photobleaching, suggesting traffic contributes to polarization. We...
Sodium and its associated anions are the major determinant of extracellular fluid volume, reabsorption Na+ by kidney plays a crucial role in long-term blood pressure control. The goal this study was to investigate extent which inhibitors transepithelial transport (TNa) along nephron alter urinary solute excretion TNa efficiency how those effects may vary different segments. To accomplish that goal, we used multinephron model developed companion (28). That represents detailed transcellular...
The goal of this study is to investigate the functional implications sexual dimorphism in transporter patterns along proximal tubule. To do so, we have developed sex-specific computational models solute and water transport convoluted tubule rat kidney. account for sex differences expression levels apical basolateral transporters, single-nephron glomerular filtration rate, tubular dimensions. Model simulations predict that 70.6 38.7% filtered volume reabsorbed by male female kidneys,...
The goal of the present study was to investigate functional implications sexual dimorphism in pattern transporters along rodent nephron as reported by Veiras et al. ( J Am Soc Nephrol 28: 3504–3517, 2017). To do so, we developed sex-specific computational models water and solute transport superficial nephrons from male female rat kidneys. account for sex differences abundance apical basolateral transporters, single glomerular filtration rate, tubular dimensions. Model simulations predict...
Each day, ~1.7 kg of NaCl and 180 liters water are reabsorbed by nephron segments in humans, with urinary excretion fine tuned to meet homeostatic requirements. These tasks coordinated a spectrum renal Na + transporters channels. The goal the present study was investigate extent which inhibitors transepithelial transport (T ) along alter solute how those effects may vary between male female subjects. To accomplish that goal, we developed sex-specific multinephron models represent detailed...
The kidneys maintain homeostasis by controlling the amount of water and electrolytes in blood. That function is accomplished nephrons, which transform glomerular filtrate into urine a transport process mediated membrane transporters. We postulate that distribution renal transporters along nephron markedly different between men women, as recently shown rodents. hypothesize larger abundance Na+ proximal tubules females may also better prepare them for fluid retention adaptations required...
Abstract A year after the initial wild-type Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strains began their devastation of world, they were supplanted by new variants concern (VOC). In Ontario, Canada, wild type was overtaken first Alpha/B1.1.17 variant, and then Delta/B.1.617 variant. The principal objective present study is to develop apply a much expanded Susceptible-Infection-Recovered-type model better understand spread multiple VOC, assess effectiveness vaccination...
In problems with interfaces, the unknown or its derivatives may have jump discontinuities.Finite difference methods, including method of A. Mayo and immersed interface R. LeVeque Z. Li, maintain accuracy by adding corrections, found from jumps, to operator at grid points near modifying if necessary.It has long been observed that solution can be computed uniform O.h 2 / even truncation error is O.h/ interface, while in interior.We prove this fact for a class static elliptic type using...