A5057269172- Law and Political Science
- Neurogenesis and neuroplasticity mechanisms
- Diverse Legal and Medical Studies
- German Literature and Culture Studies
- Nerve injury and regeneration
- Public Administration and Political Analysis
- Nuclear Receptors and Signaling
- Medical and Health Sciences Research
- Corporate Governance and Law
- Axon Guidance and Neuronal Signaling
- Wastewater Treatment and Reuse
- Groundwater and Isotope Geochemistry
- Criminal Law and Policy
- Neuroscience and Neuropharmacology Research
- Wnt/β-catenin signaling in development and cancer
- Economic and Social Issues
- Mesenchymal stem cell research
- Photochromic and Fluorescence Chemistry
- Signaling Pathways in Disease
- Microtubule and mitosis dynamics
- Fatty Acid Research and Health
- European and International Contract Law
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Prenatal Substance Exposure Effects
IQVIA (United States)
2024
Karolinska Institutet
1998-2005
Rockefeller University
2003
Columbia University
2003
University of Freiburg
1903-2000
Universitat de Barcelona
1999
Rutgers, The State University of New Jersey
1997
University of Rochester
1989
University of Lausanne
1905-1911
Oberlandesgericht Stuttgart
1908-1910
Mounting evidence indicates that extracellular factors exert proliferative effects on neurogenetic precursors in vivo. Recently we found systemic levels of basic fibroblast growth factor (bFGF) regulate neurogenesis the brain newborn rats, with apparently crossing blood-brain barrier (BBB) to stimulate mitosis. To determine whether peripheral bFGF affects proliferation during adulthood, focused regions which persists into maturity, hippocampus and forebrain subventricular zone (SVZ). In...
The Wnts are a family of glycoproteins that regulate cell proliferation, fate decisions, and differentiation. In our study, we examined the contribution to development ventral midbrain (VM) dopaminergic (DA) neurons. Our results show β-catenin is expressed in DA precursor cells signaling takes place these cells, as assessed TOPGAL [Tcf optimal-promoter β-galactosidase] reporter mice. We also found Wnt-1, -3a, -5a expression differentially regulated during partially purified distinctively VM...
This study evaluates functional recovery after transplanting human bone marrow-derived stromal cells (BMSCs) into contusion models of spinal cord injury (SCI). The authors used a high-throughput process to expand BMSCs and characterized them by flow cytometry, ELISA, gene expression. They found that secrete neurotrophic factors cytokines with therapeutic potential for cell survival axon growth. In adult immune-suppressed rats, mild, moderate, or severe contusions were generated using the...
Abstract: Neurturin (NTN) and glial cell line‐derived neurotrophic factor (GDNF), two members of the GDNF family growth factors, exert very similar biological activities in different systems, including substantia nigra. Our goal present work was to compare their function define whether nonoverlapping on midbrain dopaminergic neurons exist. We first found that NTN are differentially regulated during postnatal development. mRNA progressively decreased ventral mesencephalon increased striatum,...
The retinoid X receptor (RXR) is essential as a common heterodimerization partner of several nuclear receptors (NRs). However, its function bona fide for endogenous ligands has remained poorly understood. Such role would depend on the existence RXR activating in vivo and ability such to influence relevant biological functions. Here we demonstrate presence embryonic central nervous system (CNS) show that they can activate heterodimers formed between orphan NR Nurr1 vivo. Moreover, increase...
PURPOSE Real-world data (RWD) holds promise for ascribing a real-world (rw) outcome to drug intervention; however, ascertaining rw-response treatment from RWD can be challenging. Friends of Cancer Research formed collaboration assess available attributes related across sources inform methods capturing, defining, and evaluating rw-response. MATERIALS AND METHODS This retrospective noninterventional (observational) study included seven electronic health record companies (data providers)...
Noradrenergic neurons of the locus coeruleus (LC) express receptor tyrosine kinase c-ret, which binds ligands glial cell line-derived neurotrophic factor (GDNF) family. In present study, we evaluated function neurturin (NTN), a GDNF family ligand whose on LC is unknown. Interestingly, found that hydroxylase (TH)-positive in both GFRalpha1 and 2 receptors developmentally regulated fashion, suggesting for their preferred ligands: NTN, respectively. Moreover, our results show NTN mRNA...
A study was made of an irrigated area in Arizona to evaluate costs and benefits associated with desalting saline ground water from seven wells as improved source for irrigation. Both multistage flash distillation (MSF) electrodialysis (ED) processes were evaluated. The involved 1376 acres near Buckeye, Arizona. Well quality varied 1580 4600 ppm. Irrigation qualities 400, 900, 1500 ppm are developed by the two processes. Adaptable cropping patterns selected maximum returns. total six...