Michele Bedognetti
A5090868093- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Immune Response and Inflammation
- Bacillus and Francisella bacterial research
- COVID-19 diagnosis using AI
- Polyomavirus and related diseases
- Respiratory viral infections research
- Gut microbiota and health
- Melanoma and MAPK Pathways
- Pneumonia and Respiratory Infections
University of Münster
2024
The University of Queensland
2024
Westmead Institute for Medical Research
2024
ASL Roma
2021-2022
University of Genoa
2010
Viral respiratory tract infections are frequently complicated by secondary bacterial infections. This study aimed to use machine learning predict the risk of superinfection in SARS-CoV-2-positive individuals.
Knowledge of the mechanisms underpinning development protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) vaccination via high-temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 5, respectively. second dose, in contrast, sharp day 1 interferon, inflammation, erythroid cell followed a 5 plasmablast response....
Introduction Accurate triage is an important first step to effectively manage the clinical treatment of severe cases in a pandemic outbreak. In current COVID-19 global pandemic, there lack reliable tools assist clinicians perform accurate triage. Host response biomarkers have recently shown promise risk stratification disease progression; however, role these predicting progression patients with unknown. Here, we present protocol outlining prospective validation study evaluate biomarkers’...
ABSTRACT Knowledge of the mechanisms underpinning development protective immunity conferred by mRNA vaccines is fragmentary. Here we investigated responses to COVID-19 vaccination via ultra-low-volume sampling and high-temporal-resolution transcriptome profiling (23 subjects across 22 timepoints, with 117 patients used as comparators). There were marked differences in timing amplitude priming booster doses. Notably, identified two distinct interferon signatures. The first signature (A28/S1)...