A5033640268- Bone health and treatments
- Cancer Diagnosis and Treatment
- Bone Metabolism and Diseases
- Light effects on plants
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Bone health and osteoporosis research
- Bone and Joint Diseases
Odense University Hospital
2023
University of Southern Denmark
2023
University of Freiburg
2018
Optogenetic approaches have gathered momentum in precisely modulating and interrogating cellular signalling gene expression. The use of optogenetics on the outer cell surface to interrogate how cells receive stimuli from their environment, however, has so far not reached its full potential. Here we demonstrate development an optogenetically regulated membrane receptor-ligand pair exemplified by optically responsive interaction integrin receptor with extracellular matrix. system is based...
Clinical studies indicate that microvascular disease (MVD) affects bone microstructure and decreases strength in type 2 diabetes mellitus (T2D). Osteocytes are housed small voids within the matrix lacunae act as sensors of mechanical forces bone. These cells regulate osteoclastic resorption osteoblastic formation well osteocytic perilacunar remodeling. We hypothesized MVD changes morphometric osteocyte lacunar parameters individuals with T2D. collected iliac crest biopsies from 35 (10...