A5071947682- Cervical Cancer and HPV Research
- Genital Health and Disease
- Urologic and reproductive health conditions
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Urological Disorders and Treatments
- Tumors and Oncological Cases
- Reproductive System and Pregnancy
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Whipple's Disease and Interleukins
- Cancer Risks and Factors
- Myasthenia Gravis and Thymoma
- Nonmelanoma Skin Cancer Studies
- Genetic factors in colorectal cancer
- Intraperitoneal and Appendiceal Malignancies
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Hepatitis B Virus Studies
- Soft tissue tumor case studies
- Cancer-related molecular mechanisms research
- Neurogenetic and Muscular Disorders Research
Counties Manukau District Health Board
2019-2025
Middlemore Hospital
2011-2023
Auckland City Hospital
2011-2016
In-Q-Tel
2014
Edinburgh Royal Infirmary
2006
Medlab Central (New Zealand)
2004
Squamous cell carcinoma of the vulva (SCCV) develops through either human papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% SCCV arise independently HPV, commonly in a background an inflammatory dermatosis, particularly lichen sclerosus. The likely direct precursor to most these lesions is vulvar intraepithelial neoplasia (VIN), differentiated type (dVIN), although evidence largely circumstantial. There are few reports progression carcinoma, and natural history...
Background: Biphasic sarcomatoid carcinoma (BSC), or carcinosarcoma, is an uncommon biphasic neoplasm that has been reported in diverse anatomical sites. The tumor composed of a malignant epithelial component intimately associated with mesenchymal component, which may be homologous heterologous. Twenty‐three cases primary cutaneous BSC have the English literature. In only eight these was basal cell component. Methods: We report further four carcinoma, and include clinical, histological...
This study aimed to investigate the impact of resection margins on first local recurrence vulvar squamous cell carcinoma, stratified by human papillomavirus (HPV) status: HPV-associated (HPV-A) and HPV-independent (HPV-I). It also investigated association between precursor lesions carcinoma at risk recurrence. was a retrospective single-center clinicopathological case note review patients treated with primary surgery for January 1990 December 2020, follow-up until February 2024. The...
Aggressive angiomyxoma (AA) is a benign, slow-growing tumor that characteristically occurs in women of reproductive age. Local recurrence cited 30% to 40% cases. Wide local excision the treatment choice. However, recent reports suggest role for hormone manipulation management these tumors. The morphology and immunophenotype AA overlap with other, mainly benign vulvovaginal mesenchymal Diagnosis rests primarily on hematoxylin eosin staining features, distinction important determining...
We report the disease-specific survival of patients with human papillomavirus (HPV)-associated and HPV-independent vulvar squamous cell carcinomas determine whether differences exist are independent stage age at diagnosis.
Background: The most frequent molecular abnormality observed in dermatofibrosarcoma protuberans (DFSP) is the formation of a supernumerary ring chromosome or translocation resulting fusion gene encoding α‐chain type 1 collagen, COL1A1 from 17q22, to platelet‐derived growth factor β‐chain, PDGFB 22q13. Rare cases documenting variant marker chromosomes involving regions other than 17q22 and 22q13 have been reported. Further analysis three these demonstrated presence genes. Methods: We report...
Background Endometrial carcinoma (EC) is increasing in incidence, attributed largely to the obesity epidemic. Ethnic differences New Zealand have long been recognised, with Pacific women bearing greater burden of disease. We hypothesise that pooled national incidence rates underestimate true EC our high‐risk community. Aims aimed to: (1) determine trends and outcome community served by hospital, relative data; (2) examine associated demographic, clinicopathological features reference risk...
BACKGROUNDTo use contemporary biochemical markers to characterize mRNA/gene expression in the potentially fertile secretory endometrium confirm its identification based on histological characteristics order develop a clinically applicable test.
Objective The human papillomavirus (HPV) vaccine, introduced in New Zealand (NZ) 2008, is predicted to substantially lower the incidence of HPV-associated precancers and cancers. aim this study estimate proportion vulvar intraepithelial neoplasia (VIN) lesions invasive squamous cell carcinomas (SCCV) attributable HPV NZ women treated by Auckland Regional Gynecological Oncology Service, covering an estimated 50% population. Materials Methods Polymerase chain reaction reverse hybridization...
<h3>Introduction</h3> Vulvar Squamous Cell Carcinoma (VSCC) is classified as Human Papilloma Virus Associated (HPV-A) or HPV Independent (HPV-I), with HPV-I VSCC having greater risk of recurrence and poorer survival. Surgical guidelines do not distinguish between the aetiologies all previous surgical margins publications report together, traditionally recommending a 8 mm pathological margin. This study investigates impact resection on first local stratified by HPV-A subtypes....