A5058475585- Cervical Cancer and HPV Research
- Genital Health and Disease
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Reproductive tract infections research
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- Cancer survivorship and care
- Cleft Lip and Palate Research
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Chromatin Remodeling and Cancer
- Polyomavirus and related diseases
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
Université de Reims Champagne-Ardenne
2016-2025
Centre Hospitalier Universitaire de Reims
2015-2025
Inserm
2016-2025
Hôpital Maison Blanche
2006-2024
Pathologies Pulmonaires et Plasticité Cellulaire
2018-2023
Conseil Régional de Champagne-Ardenne
2019
Hôpital Robert-Debré
2019
Laboratoire Excell
2006-2015
Institut Jean Godinot
2015
University of Liège
2014
Abstract Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion infected women will develop high‐grade intraepithelial neoplasia or cancer (CIN2/3+). We performed prospective study including 781 with normal, atypical squamous cells undetermined significance (ASCUS) low‐grade lesion (LGSIL) cytology, and not by high‐risk (HR) tested Hybrid Capture II. Women were followed up every 6 months for median period 22 months. Among HR‐HPV‐positive at entry,...
Integration of human papillomavirus (HPV) DNA into the host cell genome is a frequent event in cervical carcinogenesis, even though this phenomenon does not seem to be mandatory for cancer development. Our objective was describe load and physical state HPV type 16 (HPV16) series samples representative natural history cancer. We used combination three real-time PCR assays targeting E6, E2, albumin genes calculate HPV16 (E6 albumin) E2/E6 ratio as surrogate integration. This method applied 173...
Patients with human papillomavirus (HPV)-related oropharyngeal tumors display improved prognosis. The biological basis of this tumor phenotype is poorly understood. We investigated whether increased lymphocyte infiltrate in HPV-positive squamous cell carcinomas could account for better previously identified, an Affymetrix GeneChip analysis 83 HPV-unrelated and 11 HPV-related carcinoma the oropharynx, several candidate genes, including CD8α CD3ζ. Their expression was validated study by...
Infections with high-risk human papillomaviruses (HPV), mainly HPV type 16, can cause malignant transformation of the cervical epithelium and development cancer (CxCa). A rapid precise diagnosis precancerous lesions by conventional cytology or DNA tests remains difficult often leads to overtreatment. We quantitatively analyzed HPV16 transcriptome 80 DNA-positive scrapes classified as mild cytologic grade, including no intraepithelial lesion malignancy (NIL/M; normal, n=25) low-grade squamous...
Abstract Human papillomavirus (HPV) infection is the most important event in malignant transformation of human cervical epithelium. We analysed smears, HPV genotypes with a focus on single/multiple infections, then characteristics HPV‐16 infections (presence other genotypes, viral load and physical state) according to grade histological lesions. The purpose this study was know if these parameters could allow differentiate diagnoses. DNA extracted from 363 samples corresponding 24 cases...
Abstract In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro and vivo invasiveness cancer. Tumor cell invasion facilitated by epithelial–mesenchymal transition (EMT), a process which tumor cells lose their epithelial features acquire mesenchymal cell-like phenotype. this study, the mechanism underlying Fhit-regulated EMT was deciphered. Using Slug knockdown,...
Abstract Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status assessed to detect Lynch syndrome, guide adjuvant chemotherapy, determine prognosis, and use as a companion test for checkpoint blockade inhibitors. Traditionally, determined by immunohistochemistry or molecular methods. The Idylla™ Assay fully automated method (including result interpretation), using seven novel biomarkers ( ACVR2A , BTBD7 DIDO1 MRE11 RYR3 SEC31A SULF2 ) not requiring...
Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions cancer. Factors that favour persistence versus clearance are still poorly understood, but several studies have suggested intra-type variants may influence clinical outcome. The aim this study was assess the possible association between risk for viral in general population France.One hundred forty two women infected with normal cytology, without previous treatment lesions, valid second follow-up...
Human Papillomavirus (HPV) infection is recognised as aetiological factor of carcinogenesis in oropharyngeal squamous cell carcinomas (OPC). HPV-related OPC respond better to treatments and have a significantly favourable outcome. Epithelial mesenchymal transition (EMT) implicated tumour invasion, hallmark poor prognosis carcinomas. We studied the relationship EMT markers (E-cadherin, β-catenin vimentin) with HPV (DNA E6/E7 mRNA detection), p16INK4a expression survival outcomes cohort 296...
Osimertinib, a third-generation tyrosine kinase inhibitor that targets epidermal growth factor receptor (EGFR), specifically inhibits both EGFR inhibitor-sensitive mutations and T790M resistance mutations. Despite initial positive responses to inhibitors, nearly all patients eventually experience disease progression. Mechanisms of are classically divided into EGFR-dependent EGFR-independent mechanisms, such as the activation alternative pathways histological changes. We report case...
Lung cancer, especially non-small cell lung cancer (NSCLC), poses a significant global health challenge due to its high prevalence and poor prognosis despite treatment advancements, including immunotherapy. While programmed death-ligand 1 (PD-L1) expression is commonly used biomarker, limitations justify exploration of alternative markers like the neutrophil-to-lymphocyte ratio (NLR), absolute neutrophil count (ANC) derived NLR (dNLR). This retrospective study aims directly compare NLR, ANC...
A fraction of oropharyngeal cancer (OPC), especially in the tonsil, is caused by human papillomavirus (HPV), mainly HPV16. Noninvasive diagnostic methods to detect precancerous lesions tonsil would be useful, e.g., liquid-based cytology (LBC). However, ill-characterized may hidden depth tonsillar crypts. We therefore conducted a study on HPV and evaluate, among other things, utility LBC obtained deep brushing resected tonsils. Two hundred non-paediatric patients (mean age: 30.3 years) who...