A5033068092- Archaeology and ancient environmental studies
- Pacific and Southeast Asian Studies
- RNA modifications and cancer
- Smart Materials for Construction
- Urban and Rural Development Challenges
- Global Maritime and Colonial Histories
- Virus-based gene therapy research
- Conservation Techniques and Studies
- Indigenous Studies and Ecology
- Ecology and Conservation Studies
- Health, Environment, Cognitive Aging
- Meta-analysis and systematic reviews
- Urban Stormwater Management Solutions
- Isotope Analysis in Ecology
- Cancer-related Molecular Pathways
- Archaeological Research and Protection
- Climate change and permafrost
Wellcome Sanger Institute
2024
University of Connecticut
2021
McGill University
2019-2020
Abstract Forested wetlands of the temperate north are increasingly exposed to deicing salts, but it is unclear how this may alter wetland biogeochemistry and plant community composition. To investigate potential effects salts on exurban forested in southern New England, we employed a multi‐site field study describe spatiotemporal patterns soil physiochemical, water quality, vegetation characteristics with distance from road salt source. We surveyed nine road‐adjacent, red maple‐dominated...
Abstract Microsatellite-unstable (MSI) cancers depend on the WRN helicase to resolve replication stress from expanded (TA)-dinucleotide repeats. is a promising synthetic lethal target for MSI tumours and inhibitors are being developed. Here, we used CRISPR-Cas9 base editing map residues critical lethality, validating domain as primary guiding inhibitor discovery. Fragment-based screening led discovery of potent highly selective covalent same chemical series. These compounds strikingly...
Abstract Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due expanded DNA (TA)n-dinucleotide repeats. is a promising synthetic lethal target for MSI tumours, and inhibitors are in development. Here, we used CRISPR-Cas9 base editing map residues critical cells, validating the domain as primary drug target. Fragment-based screening led development of potent highly selective covalent inhibitors. These compounds selectively suppressed model growth In...