A5091124725- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Neurogenesis and neuroplasticity mechanisms
- Antibiotic Resistance in Bacteria
- Proteoglycans and glycosaminoglycans research
- Intracranial Aneurysms: Treatment and Complications
- Photoacoustic and Ultrasonic Imaging
- Blood properties and coagulation
- Neuropeptides and Animal Physiology
- Cerebrospinal fluid and hydrocephalus
- Blood Coagulation and Thrombosis Mechanisms
- Ultrasound Imaging and Elastography
- Atomic and Subatomic Physics Research
- Bacterial biofilms and quorum sensing
- Genetics and Neurodevelopmental Disorders
- Wireless Power Transfer Systems
- Cultural Heritage Materials Analysis
- Building materials and conservation
- Cultural Differences and Values
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Social and Intergroup Psychology
- Genomics and Phylogenetic Studies
University of Virginia
2019-2024
University of Alberta
2022
University of Tennessee at Knoxville
2019-2020
Tufts University
2020
Temple College
1988
Temple University
1988
University of Pennsylvania
1987
Abstract A unique, protective cell envelope contributes to the broad drug resistance of nosocomial pathogen Acinetobacter baumannii . Here we use transposon insertion sequencing identify A. mutants displaying altered susceptibility a panel diverse antibiotics. By examining with antibiotic profiles that parallel mutations in characterized genes, infer function multiple uncharacterized proteins, some which have roles division or elongation. Remarkably, affecting predicted wall hydrolase lead...
Treatment of many pathologies the brain could be improved markedly by development noninvasive therapeutic approaches that elicit robust, endothelial cell-selective gene expression in specific regions are targeted under MR image guidance. While focused ultrasound (FUS) conjunction with gas-filled microbubbles (MBs) has emerged as a modality for image-guided delivery to brain, it been used exclusively transiently disrupt blood–brain barrier (BBB), which may induce sterile inflammation...
Abstract Cortical neuronal circuits along the sensorimotor pathways are shaped by experience during critical periods of heightened plasticity in early postnatal development. After closure periods, measured histologically formation and maintenance extracellular matrix structures called perineuronal nets (PNNs), adult mouse brain exhibits restricted maturity. Mature PNNs typically considered to be stable that restrict synaptic on cortical parvalbumin+ (PV+) GABAergic neurons. Changes...
Cerebral cavernous malformations, also known as angiomas, are blood vessel abnormalities comprised of clusters grossly enlarged and hemorrhage-prone capillaries. The prevalence in the general population, including asymptomatic cases, is estimated to be 0.5%. Some patients develop severe symptoms, seizures focal neurological deficits, whereas others remain asymptomatic. causes this remarkable presentation heterogeneity within a primarily monogenic disease poorly understood.
BACKGROUND Cerebral cavernous malformations (CCM) are vascular lesions within the central nervous system, consisting of dilated and hemorrhage-prone capillaries. CCMs can cause debilitating neurological symptoms, surgical excision or stereotactic radiosurgery only current treatment options. Meanwhile, transient blood-brain barrier opening (BBBO) with focused ultrasound (FUS) microbubbles is now understood to exert potentially beneficial bioeffects, such as stimulation neurogenesis clearance...
Previous studies in cultural psychology have suggested that when assessing a target person's emotion, East Asians are more likely to incorporate the background figure's emotion into judgment of target's compared North Americans. The objective this study was further examine variation perception within culturally diverse population is representative Canada's multicultural society. We aimed see whether East-Asian Canadians tended keep holistic tendencies their heritage culture regarding...
Gram-negative septicemia is known to be associated with activation of the contact system and disseminated intravascular coagulation. Alpha-l-antitryosin-Pittsburgh (AT-P), a naturally occurring lethal nutation (358Met →> Arg) potent inhibitor all enzymes as well coagulation enzyme, thrombin. We hypothesized that administration AT-P might modulate course gram-negative sepsis. The pig was selected animal model choice since its fibrinolytic, kinin-forming, systems are similar man response...
Cerebral cavernous malformations (CCMs) are vascular neoplasms in the brain that can cause debilitating symptoms. Current treatments pose significant risks to some patients, motivating development of new nonsurgical options. We recently discovered focused ultrasound-mediated blood-brain barrier opening (FUS) arrests CCM formation and growth. Here, we build on this discovery assess ability FUS deliver model therapeutics into CCMs.
Motivation: While GRE and SWI are the primary methods for identifying iron deposition in cerebral cavernous malformation (CCM), improved preclinical lesion characterization can be achieved by using Quantitative Susceptibility Mapping (QSM). Goal(s): Our goal was to introduce use of QSM a CCM model evaluate impact different available. Approach: 8 healthy mice 13 were scanned multi-gradient echo images processed through each method then compared RMSE. Results: Each displayed large...
Cortical neuronal circuits along the sensorimotor pathways are shaped by experience during critical periods of heightened plasticity in early postnatal development. After closure periods, measured histologically formation and maintenance extracellular matrix structures called perineuronal nets (PNNs), adult mouse brain exhibits restricted maturity. Mature PNNs typically considered to be stable that restrict synaptic on cortical parvalbumin+ GABAergic neurons. Changes environment (i.e. novel...
Abstract Acinetobacter baumannii is an opportunistic pathogen that a critical, high-priority target for new antibiotic development. Clearing of A. requires relatively high doses antibiotics across the spectrum, primarily due to its protective cell envelope. Many proteins support envelope integrity and modulate drug action are uncharacterized, largely because there absence orthologs several perform essential envelope-associated processes, impeding progress on this front. To identify targets...
Abstract Cerebral cavernous malformations (CCM), also known as angiomas, are blood vessel abnormalities comprised of clusters grossly enlarged and hemorrhage-prone capillaries. The prevalence in the general population, including asymptomatic cases, is estimated to be 0.5%. Some patients develop severe symptoms, seizures focal neurologic deficits, while others have no symptoms. causes this remarkable presentation heterogeneity within a primarily monogenic disease remain poorly understood. To...