A5011286545- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Fractal and DNA sequence analysis
- Anesthesia and Sedative Agents
- Diabetes Treatment and Management
- Glioma Diagnosis and Treatment
- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
The University of Texas Health Science Center at Houston
2015-2024
McMaster University
2023-2024
Memorial Hermann
2023-2024
Texas Medical Center
2023-2024
Hamilton Health Sciences
2024
The University of Texas at Austin
2016
Cleveland Clinic
2015
Epilepsy Foundation
2015
University of British Columbia
2002
<h3>Importance</h3> A major change has occurred in the evaluation of epilepsy with availability robotic stereoelectroencephalography (SEEG) for seizure localization. However, comparative morbidity and outcomes this minimally invasive procedure relative to traditional subdural electrode (SDE) implantation are unknown. <h3>Objective</h3> To perform a analysis efficacy, procedural morbidity, consequent SEEG SDE similar patient populations performed by single surgeon at 1 center. <h3>Design,...
Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) To evaluate this, as well to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and or 43 consecutive patients undergoing MTL epilepsy.All underwent unilateral structures. FreeSurfer software was...
Glucose-dependent insulinotropic polypeptide (GIP) is secreted postprandially and acts in concert with glucose to stimulate insulin secretion from the pancreas. Here, we describe a novel pathway for regulation of GIP receptor (GIPR) expression within clonal beta-cell lines, pancreatic islets, vivo. High (25 mM) was able significantly reduce GIPR mRNA levels INS(832/13) cells after only 6 h. In contrast, palmitic acid (2 WY 14643 (100 microM) stimulated approximate doublings under low (5.5...
Pharmacologic sedation is often used to induce burst suppression in cases of refractory status epilepticus, but there little evidence guide the weaning sedation. Similarly, morphologic feature bursts unknown clinical relevance. Recently, standardized American Clinical Neurophysiology Society terminology critical care EEG introduced term highly epileptiform (HEBs). Knowing association HEBs with seizure may direct therapy for epilepticus.Consecutive adult patients classified as having were...
Abstract Objective Stereo‐electroencephalography (SEEG) is the preferred method for intracranial localization of seizure‐onset zone (SOZ) in drug‐resistant focal epilepsy. Occasionally SEEG evaluation fails to confirm pre‐implantation hypothesis. This leads a decision tree regarding whether addition electrodes (two‐step – 2sSEEG) or placement subdural (SDEs) after (SEEG2SDE) would help. There dearth literature encompassing this scenario, and here we aimed characterize outcomes following...
Stereoelectroencephalography (SEEG) is designed to target distributed cortical networks responsible for electroclinical seizure syndrome and enable localization of the site onset in patients with intractable epilepsy. When preimplantation hypothesis invokes bilateral mesial frontal lobes, sampling several deep-seated sites both hemispheres required. In this study, authors have demonstrated feasibility bihemispheric areas intentional implantation an SEEG electrode crossing midline (SECM)...
Abstract Auditory auras are typically considered to localize the temporal neocortex. Herein, we present two cases of frontal operculum/perisylvian epilepsy with auditory auras. Following a non‐invasive evaluation, including ictal SPECT and magnetoencephalography, implicating operculum, these were evaluated invasive monitoring, using stereoelectroencephalography subdural (plus depth) electrodes, respectively. Spontaneous electrically‐induced seizures showed an onset involving operculum in...
Stereoelectroencephalography (SEEG) has emerged as a transformative tool in epilepsy surgery, shedding light on the complex network dynamics involved focal epilepsy. This review explores role of SEEG elucidating deep brain structures, namely basal ganglia and thalamus, advances understanding their contribution to seizure generation, propagation, control by permitting precise minimally invasive sampling these regions. The ganglia, comprising subthalamic nucleus, globus pallidus, substantia...
Objective Periventricular nodular heterotopia (PVNH) is the most common neuronal heterotopia, frequently resulting in pharmaco‐resistant epilepsy. Here, we characterize variables that predict good epilepsy outcomes following surgical intervention using stereo‐electroencephalography (SEEG) ‐informed magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT). Methods A retrospective review of consecutive cases from a single high‐volume referral center identified patients who...
Summary Dysembryoplastic neuroepithelial tumors (DNETs) are World Health Organization grade 1 neoplasms, typically present as isolated cortical lesions with no associated edema. We 3 rare cases of DNETs that were atypical in location (all subcortical and was bilateral), 2 which displayed substantial growth over time. All presented seizures not well controlled on medications, followed by a successful cure the epilepsy when these removed. These uniquely illustrate can be throughout brain may...
Infraslow activity (ISA) occurring during the interictal state in focal epilepsy is largely unstudied. In this exploratory analysis, authors aimed to characterize features of ISA a cohort patients studied by stereoelectroencephography.The stereoelectroencephography records for 15 consecutive adult were retrospectively analyzed, after application both conventional (1.6-70 Hz) and infraslow (0.01-0.1 bandpass filters. Visual analysis was complemented time-frequency quantify change power over...
Magnetoencephalography (MEG) is recognized as a valuable non-invasive clinical method for localization of the epileptogenic zone and critical functional areas, part pre-surgical evaluation patients with pharmaco-resistant epilepsy. MEG also useful in localizing areas planning tumor resection. usually performed an outpatient setting, one that can include variety other testing modalities including 3-Tesla MRI inpatient video-electroencephalography monitoring. In some circumstances, however,...
Abstract Objective Periventricular Nodular Heterotopia (PVNH) is the most common neuronal heterotopia, frequently resulting in pharmaco-resistant epilepsy. PVNH has a deep location which renders localization of seizure onsets and traditional surgical therapy challenging limited success. Here we characterize variables that predict good epilepsy outcomes following intervention using SEEG-informed MRgLITT. Methods A prospectively compiled database from single high-volume referral center was...