A5074757064- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Glaucoma and retinal disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Neural dynamics and brain function
- Ophthalmology and Eye Disorders
- Migraine and Headache Studies
- Mental Health Research Topics
- Circadian rhythm and melatonin
- Genetic Associations and Epidemiology
- Retinal Development and Disorders
- Biometric Identification and Security
- Pain Mechanisms and Treatments
- Hereditary Neurological Disorders
- Laser Applications in Dentistry and Medicine
- Functional Brain Connectivity Studies
- User Authentication and Security Systems
- Treatment of Major Depression
- Obstructive Sleep Apnea Research
- Psychology of Moral and Emotional Judgment
- Agricultural risk and resilience
- Decision-Making and Behavioral Economics
- Spatial Neglect and Hemispheric Dysfunction
- EEG and Brain-Computer Interfaces
The University of Queensland
2000-2024
Vietnam National University of Agriculture
2022-2023
Queens University
2022
Translational Research Institute
2018-2022
Mater Research
2017-2018
QIMR Berghofer Medical Research Institute
2013-2018
Monash Alfred Psychiatry Research centre
2007-2017
The Alfred Hospital
2007-2017
Monash University
2007-2017
University of Dundee
2013
The bidirectional relationship between depression and chronic pain is well-recognized, but their clinical management remains challenging. Here we characterize the shared risk factors outcomes for comorbidity in Australian Genetics of Depression cohort study (
Binocular rivalry occurs when conflicting images are presented in corresponding locations of the two eyes. Perception alternates between at a rate that is relatively stable within individuals but varies widely individuals. The determinants this variation unknown. In addition, slow binocular has been demonstrated bipolar disorder, psychiatric condition with high heritability. present study therefore examined whether there genetic contribution to individual rate. We employed twin method and...
Background. The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than controls when tested drifting, vertical and horizontal gratings high spatial frequency. Method. Here we assess the stationary, low frequency 30 disorder, age- sex-matched controls, 18 schizophrenia major depression. Along rate, predominance each rivaling images was assessed, as distribution normalized intervals. Results. group demonstrated significantly control, depression groups....
Objective: Caloric vestibular stimulation (CVS) has traditionally been used as a tool for neurological diagnosis. More recently, however, it applied to range of phenomena within the cognitive neurosciences. Here, we provide an overview such studies and review our work using CVS investigate neural mechanisms visual phenomenon – binocular rivalry. We outline interhemispheric switch model rivalry supported by this its extension metarivalry interocular-grouping phenomena. In addition, showing...
Human perception, and consequently behavior, is driven by attention dynamics. In the special case of rivalry, where alternates between competing percepts, such dynamics can be measured their determinants investigated. A recent study in fruit fly, Drosophila melanogaster, now shows that origins attentional rivalry may quite ancient. Furthermore, individual variation exists rate both humans flies, this under substantial genetic influence. pathophysiological realm, slowing associated with...
ABSTRACT Chronic pain (pain on most days or daily for ≥3 months) is prevalent among people living with Parkinson’s disease (PD). We analysed data from 10,631 Australian individuals PD to assess the prevalence, severity, anatomical distribution, clinical history, and associated factors. Two-thirds (66.2%) reported chronic pain, females experiencing higher prevalence (70.8%) severity (4.7 vs. 4.3 a 10-point scale). Common sites included buttocks (35.6%), lower back (25.4%), neck (19.4%), knees...
Abstract Structural neuroimaging studies of individuals with chronic pain conditions have often observed decreased regional grey matter at a phenotypic level. However, it is not known if this association can be attributed to genetic factors. Here we employed novel integrative data-driven and hypothesis-testing approach determine whether there basis morphology differences in pain. Using publicly available genome-wide study summary statistics for (n = 196 963) structural measures 19 629–34...
Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder can be explained by shared genetic variants; (ii) higher CRP levels causally contribute to these conditions.
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Chronic pain and depression are highly comorbid difficult-to-treat disorders. We previously showed this comorbidity is associated with higher severity, lower antidepressant treatment effectiveness poorer prognosis in the Australian Genetics of Depression Study.The current study aimed to assess whether a genetic liability chronic over above effect factors for sample 12,863 Study participants.Polygenic risk scores were calculated using summary statistics from genome-wide association studies...
Binocular rivalry (BR) is an intriguing phenomenon in which conflicting images are presented, one to each eye, resulting perceptual alternations between image. The rate of BR has been proposed as a potential endophenotype for bipolar disorder because (a) it well established that this highly heritable psychiatric condition associated with slower than controls, and (b) individual’s approximately 50% genetically determined. However, eye movements (EMs) could potentially account the slow trait...
Abstract Chronic pain (CP) is a leading cause of disability worldwide with complex aetiologies that remain elusive. Here we addressed this issue by performing GWAS on large UK Biobank sample (N=188,352 cases & N=69,627 controls) which identified two independent loci associated CP near ADAMTS6 and LEMD2 . Gene-based tests revealed additional CP-associated genes ( DCAKD, NMT1, MLN, IP6K3 ). Across 1328 traits, 548 (41%) were genetically correlated CP, 175 (13%) showed genetic causal...