A5057979025- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Macrophage Migration Inhibitory Factor
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
University of Michigan–Ann Arbor
2023
Michigan Medicine
2022
Abstract Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor survival of patients with PDA has been attributed high rate early metastasis and low efficacy current therapies, which partly result from its complex immunosuppressive tumor microenvironment. Previous studies our group others shown that tumor-associated macrophages (TAM) are instrumental in maintaining immunosuppression PDA. Here, we explored the role Notch signaling, key regulator immune response,...
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is generally divided in two subtypes, classical and basal. Recently, single-cell RNA sequencing has uncovered the coexistence of basal cancer cells, as well intermediary individual tumors. The latter remains poorly understood; here, we sought to characterize them using a multimodal approach. Experimental Design: We performed subtyping on dataset containing 18 human PDAC samples identify multiple subtypes. generated patient-derived...
<p>Notch activation detected in C57BL/6J:CBF:H2B-Venus mouse pancreatic orthotopic tumor.</p>
<p>Notch activation in the tumor microenvironment of human PDA.</p>
<p>γ-secretase inhibitor treatment reduces expression of HES1 in vivo.</p>
<p>γ-secretase inhibitor treatment reduces expression of HES1 in vivo.</p>
<p>Notch activation detected in C57BL/6J:CBF:H2B-Venus mouse pancreatic orthotopic tumor.</p>
<p>Notch activation detected in C57BL/6J:CBF:H2B-Venus mouse pancreas and tumor microenvironment of spontaneous PanIN lesions.</p>
<p>Primer sequences for quantitative RT-PCR</p>
<p>Notch activation detected in C57BL/6J:CBF:H2B-Venus mouse pancreas and tumor microenvironment of spontaneous PanIN lesions.</p>
<p>Notch activation in the tumor microenvironment of human PDA.</p>
<p>Supplementary Legends</p>
<p>Primer sequences for quantitative RT-PCR</p>
<p>Single cell analysis of Notch signaling activation in TAMs.</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor survival of patients with PDA has been attributed high rate early metastasis and low efficacy current therapies, which partly result from its complex immunosuppressive tumor microenvironment. Previous studies our group others shown that tumor-associated macrophages (TAM) are instrumental in maintaining immunosuppression PDA. Here, we explored the role Notch signaling, key...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor survival of patients with PDA has been attributed high rate early metastasis and low efficacy current therapies, which partly result from its complex immunosuppressive tumor microenvironment. Previous studies our group others shown that tumor-associated macrophages (TAM) are instrumental in maintaining immunosuppression PDA. Here, we explored the role Notch signaling, key...
<p>Single cell analysis of Notch signaling activation in TAMs.</p>
<p>Antibodies</p>
<p>Antibodies</p>
<p>Supplementary Legends</p>
<p>Organoids recapitulate the heterogeneity of human disease and retain unique tumor cell populations characterized by expression KRT17, CXCL8 CXCL1.</p>
<p>CXCL8 is co-expressed with KRT17 and CLDN18 in a unique subpopulation of tumor epithelial cells.</p>
<div>AbstractPurpose:<p>Pancreatic ductal adenocarcinoma (PDAC) is generally divided in two subtypes, classical and basal. Recently, single-cell RNA sequencing has uncovered the coexistence of basal cancer cells, as well intermediary individual tumors. The latter remains poorly understood; here, we sought to characterize them using a multimodal approach.</p>Experimental Design:<p>We performed subtyping on dataset containing 18 human PDAC samples identify multiple...