Film-forming emulsions and films, prepared by incorporating different concentrations of clove essential oil (CEO) melaleuca (MEO) into chitosan (CS) were obtained their properties evaluated. characterized in terms qualitative assessment, hydrogen potential vitro antibacterial activity, that was carried the agar diffusion method, growth inhibition effects tested on Gram-positive microorganism Staphylococcus aureus, Gram-negative microorganisms Escherichia coli, against isolated fungi such as...

The solvent-evaporation approach was used to produce a chitosan (CS)/montmorillonite (MMT) nanocomposite film containing the anticancer drug 5-fluorouracil (5-FU). physicochemical and morphological characteristics, release profile, cytotoxic microbiological properties of films were evaluated verify their potential as biomaterial for treatment tumors. X-ray diffraction (XRD) confirmed formation CS-MMT/5-FU intercalated Fourier transform infrared (FTIR) detected characteristic 5- FU bonds in...

This study explores an innovative topical formulation to treat alopecia by encapsulating cannabidiol (CBD) in chitosan nanoparticles. CBD, widely known for its anti-inflammatory, antioxidant, and endocannabinoid-modulating effects, shows significant potential treating alopecia, a condition characterized hair loss influenced genetic, hormonal, or environmental factors. However, low water solubility presents challenge applications. To address this issue, nanoparticles were synthesized using of...

This work aimed to develop chitosan/gelatin scaffolds loaded with ethanolic extract of Jatropha mollissima (EEJM) evaluate the influence its content on properties these structures. The were prepared by freeze-drying, different EEJM contents (0–10% (w/w)) and crosslinked genipin (0.5% (w/w)). characterized through High Performance Liquid Chromatography coupled a Diode Array Detector (HPLC-DAD), determination three secondary metabolites was accomplished. physical, chemical biological...

Hydrogels are promising materials for biomedical applications due to their tunable properties. Despite significant research on optimizing the mechanical and rheological properties of chitosan hydrogels, a comprehensive analysis incorporating pH molarity neutralizing solution is still lacking. This study addresses this gap by evaluating how these factors influence characteristics hydrogels. The hydrogels were prepared using an acidic blend neutralized with sodium hydroxide solutions....

Hydrogels are promising materials for biomedical applications due to their tunable properties. Despite significant research on optimizing the mechanical and rheological properties of chitosan hydrogels, a comprehensive analysis incorporating pH molarity neutralizing solution is still lacking. This study addresses this gap by evaluating how these factors influence characteristics hydrogels. The hydrogels were prepared using an acidic blend neutralized with sodium hydroxide solutions....

In this study, a full multilevel factorial design (21 × 31 21) 2 was conducted to investigate the effects of molar mass chitosan (CS), type acid used for dissolution, and composition coagulation bath on coagulation, mechanical properties, swelling filaments. The results showed statistical significance factors in characteristics these followed Fick's second law diffusion, with an increase reducing rate, as did use acetic instead lactic acid. CS higher produced filaments larger diameters, but...

The aim of this study was to prepare chitosan (CS) filaments incorporated with N-acetyl-D-Glucosamine (GlcNAc), using the wet spinning method, in order combine GlcNAc pharmacological properties CS biological for use as absorbable suture materials. were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), uniaxial tensile testing, vitro biodegradation, and through drug release cytotoxicity studies. It observed that addition did not alter morphology filaments....

The aim of this study was to promote bioactivity the PEEK surface using sulfuric acid and piranha solution. functionalized by a treatment for 90 s solution 60 s. Chemical modification evaluated infrared spectroscopy, contact angle analysis, cytotoxicity, cell adhesion proliferation. spectroscopy characteristic band associated with sulfonation observed in all treated samples. showed an increase intensity bands, which even more significant longer (90 s). introduction sulfonic functional group...

The aim of this study was to develop a material capable rapidly absorbing bodily fluids and forming resilient, adhesive, viscoelastic hydrogel in situ prevent post-surgical adhesions. This formulated using O-carboxymethyl chitosan (O-CMCS), oxidized hyaluronic acid (OHA), crosslinking pigment derived from genipin glutamic (G/GluP). Both crosslinked (O-CMCS/OHA-G/GluP) non-crosslinked hydrogels (O-CMCS/OHA) were evaluated HAAKE™ MARS™ rheometer for their potential as barriers. A rheological...

This study aimed to obtain wet-spun chitosan (CS) filaments with mechanical properties suitable for the biomaterial weaving process, in addition evaluating physical-mechanical and biological behavior of CS woven meshes obtained. filament coagulation rate, drying methodology, morphology were evaluated. The reaction was completed 65 seconds, a logarithmic profile, compliance Fick's second law. proposed methodology does not cause dehydration saccharide rings stretching condition during modified...

This study aimed to achieve bioactivity on the PEEK surface using piranha solution through a lower functionalization time. For this purpose, occurred with and 98% sulfuric acid in proportions of 1:2, 1:1, 2:1 at periods 30, 60, 90 s. The samples treated for longer times higher concentrations registered characteristic spectroscopy band associated sulfonation. Additionally, both chemical treatments allowed opening aromatic ring, increasing number functional groups available making more...

Chitosan has been widely studied for use in different biomaterial applications. The aim of our study was to produce biodegradable threads chitosan mono- and multifilaments possible as sutures by using the wet spinning technique. We obtained wires a solution at 4%, aqueous NaOH 1 M coagulating bath. Optical microscopy scanning electron were used. also compared mechanical properties with without presence knot. Our results show that have cylindrical morphology multifilament are 74.4% larger...

Chitosan yarns, which could be used as surgical suture threads that potentiate the healing process by releasing N-acetyl-D-glucosamine (GlcNAc), were developed using wet spinning method. Scanning electron microscopy and mechanical traction tests performed, followed biodegradation in vitro release tests. Morphologically, yarns cylindrical well defined. During tensile tests, a decrease properties of wires was observed owing to addition GlcNAc; however, remained consistent with specifications...

This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide (0.5 M), 30% methanol used. The thread prepared by twisted two three monofilaments. threads obtained were characterized tensile tests scanning electron microscopy (SEM). Moreover, it verified morphological that preserve characteristics...

Early abortion is one of the most common complications during pregnancy. However, frequent handling genital region, more precisely vagina, which causes discomfort to patients in this process due frequency drug insertion, as four pills are inserted every six hours, has led search for alternatives alleviate suffering caused by practice who already a shaken emotional state. Hence, work aimed develop composites gelatin and misoprostol, using conventional single-dose delivery system. These were...

This work aimed to develop and evaluate the influence of processing variables on morphology swelling sulfonated poly(ether ether ketone) (SPEEK) spheres for possible applications as a biomaterial. We used drip method obtain with polymer starting solutions SPEEK-6 (w/v: 6%) SPEEK-10 10%), rates (20 30 mL/h), heights (5 10 cm) in experimental planning. The samples were characterized by Fourier-transform infrared spectroscopy (FTIR), optical microscopy (OM), absorption capacity...

This study aimed to develop hydrogels from carboxymethyl chitosan (CMC), and (CMC) with dexamethasone (DEX) for intraocular application, aiming provide structural stability the eye attenuation of inflammatory processes. CMC were prepared at concentrations 0.5%, 1% 2% (w/v) incorporated 10% (v/v) DEX. The samples characterized by FT-IR spectroscopic, thermogravimetric analysis, injectability, rheology, cytotoxicity. results showed that incorporation DEX did not significantly alter absorption...

The objective of this work was to produce brushite cement for orthopedic applications, based on the system wollastonite/phosphoric acid with incorporation polyethylene glycol (PEG) as a setting and processing additive. Brushite/PEG obtained by dissolution-precipitation method its physicochemical properties were characterized X-ray diffraction, compressive strength, porosimetry, biological behavior (cell adhesion bioactivity tests). results indicated formation 21.4 MPa strength 30% porosity,...

Bone cements aid in bone regeneration; however, if the handling time is not well established for material to harden, complications may arise.This work investigates effect of using polyethylene glycol (PEG) and characterize it brushite cement order obtain desirable times as its regeneration vivo analyse addition this polymer significantly modify properties.PEG 4000 was synthesised with wollastonite by phosphorization reaction form which further cured oven drying. They were characterised...

Crosslinking of chitosan (CS) woven meshes is reported in this study. CS filaments were obtained by wet spinning and hand-waved. The weft was coated with solutions (3 4% w/v) crosslinked sodium tripolyphosphate or genipin. free from superficial pores, their mechanical properties suitable for the weaving process. concentration coating, type, crosslinking time affected mesh morphology obtained. both agents confirmed spectroscopy, corroborating reduction hydrophilicity samples swelling contact...