A5083094485- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Gene Regulatory Network Analysis
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Genetic diversity and population structure
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Fungal and yeast genetics research
Stockholm University
2021-2024
University of Bern
2022-2024
Instituto Gulbenkian de Ciência
2019-2022
Abstract Epigenetic regulation of gene expression allows for the emergence distinct phenotypic states within clonal population. Due to instability epigenetic inheritance, these phenotypes can intergenerationally switch between in a stochastic manner. Theoretical studies evolutionary dynamics predict that heterogeneity enabled by this rapid switching would be favored under fluctuating environmental conditions, whereas genetic mutations, as form stable inheritance system, environment. To test...
Abstract Populations in nature rarely adapt to a single stress at time. Various biotic and abiotic factors come together produce complex environment which populations must adapt. How multiple stressors simultaneously, how trade-offs evolve between these has been of interest evolutionary biologists for decades. But natural often present logistical challenges understanding the dynamics evolution isolating genetic basis adaptation. Here we use methods experimental test adaptation proceeds...
Abstract Epigenetic inheritance allows for the emergence of phenotypic plasticity in clonal populations and enables rapid stochastic switching between distinct phenotypes. In natural environments, where stress conditions can recurrently fluctuate, clones with an epigenetic control genes targeted by selection should be fitter than that rely solely on genetic mutation. To test this prediction, we engineered switcher non-switcher yeast strains, uracil biosynthesis gene URA3 is under fluctuating...