A5055099528- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Metalloenzymes and iron-sulfur proteins
- Insect Resistance and Genetics
- Hippo pathway signaling and YAP/TAZ
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Mosquito-borne diseases and control
- Glycosylation and Glycoproteins Research
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Islamic Finance and Banking Studies
- Click Chemistry and Applications
- Bioinformatics and Genomic Networks
- Advanced Image and Video Retrieval Techniques
- Face and Expression Recognition
- Cancer-related Molecular Pathways
- COVID-19 Clinical Research Studies
- Maternal and fetal healthcare
- Folate and B Vitamins Research
- Protein Structure and Dynamics
Purdue University West Lafayette
2023-2024
All India Institute of Medical Sciences
2020-2024
University of Delhi
2013-2023
Regional Centre for Biotechnology
2020-2023
Hebrew University of Jerusalem
2020-2022
Indian Institute of Technology Roorkee
2014-2022
All India Institute of Medical Sciences Bhopal
2020-2022
Indian Institute of Technology Kanpur
2020-2021
King George's Medical University
2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2010-2020
This paper investigates bank-specific and macroeconomic factors that determine the liquidity of Indian banks. To explore association, we perform OLS, fixed effect random estimates on a data set 59 banks from 2000 to 2013. Studied include bank size, profitability, cost funding, capital adequacy deposits. GDP, inflation unemployment are considered. We also trend analysis based ownership. Findings reveal ownership affects Based panel analysis, suggest (except funding) unemployment)...
The importance of mitochondrial iron–sulfur cluster (ISC) biogenesis for human health has been well established, but the roles some components this critical pathway still remain uncharacterized in mammals. Among them is heat shock cognate protein 20 (hHSC20), putative homolog specialized DnaJ type co-chaperones, which are crucial bacterial and fungal ISC assembly. Here, we show that HSC20 can complement its counterpart yeast, Jac1p, interacts with proposed partners, hISCU hHSPA9. hHSC20...
Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by proposed role ABCB7 exporting special sulfur species for use cytosolic iron-sulfur (Fe-S) cluster biogenesis. Here, we generated inducible ABCB7-knockdown cell lines to examine time-dependent consequences loss ABCB7. We found knockdown led significant Fe-S proteins, which preceded...
RASSF proteins interact with distinct GTPase partners to regulate downstream Hippo and p53 signaling.
Iron–sulfur (Fe-S) clusters are cofactors in hundreds of proteins involved multiple cellular processes, including mitochondrial respiration, the maintenance genome stability, ribosome biogenesis and translation. Fe-S cluster is performed by enzymes that highly conserved throughout evolution, mutations numerous factors now recognized to cause a wide range previously uncategorized rare human diseases. Recently, complex formed components cytoplasmic assembly (CIA) machinery, consisting CIAO1,...
Multivalent interactions between carbohydrates and proteins enable a broad range of selective chemical processes critical biological importance. Such can extend from the macromolecular scale (1–10 nm) up to much larger scales across cell or tissue, placing substantial demands on chemically patterned materials aiming leverage similar in vitro. Here, we show that diyne amphiphiles with carbohydrate headgroups be assembled highly oriented pyrolytic graphite (HOPG) generate nanometer-resolution...
Side chain-to-side chain cyclizations represent a strategy to select family of bioactive conformations by reducing the entropy and enhancing stabilization functional ligand-induced receptor conformations. This structural manipulation contributes increased target specificity, enhanced biological potency, improved pharmacokinetic properties, lowered metabolic susceptibility. The CuI-catalyzed azide–alkyne 1,3-dipolar Huisgen's cycloaddition, prototypic click reaction, presents promising...
Hypoxia, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds. The dataset presented here is in support the development evaluation exosome laden oxygen releasing OxOBand for treatment management infectious wounds [1]. It describes additional results its wound healing. Exosomes were isolated from adipose-derived stem cells (ADSCs) characterized through dynamic light scattering (DLS) scanning electron...
The melanocortin-3 and -4 receptors are expressed in the brain play key roles regulating feeding behavior, metabolism, energy homeostasis. In present study, incorporation of β3-amino acids into a melanocortin tetrapeptide template was investigated. Four linear α/β3-hybrid tetrapeptides were designed with modifications at Phe, Arg, Trp residues agonist sequence Ac-His-dPhe-Arg-Trp-NH2. most potent mouse melanocortin-4 receptor (mMC4R) agonist, Ac-His-dPhe-Arg-β3hTrp-NH2 (8) showed 35-fold...
The melanocortin system is involved in the regulation of complex physiological functions, including energy and weight homeostasis, feeding behavior, inflammation, sexual function, pigmentation, exocrine gland function. five receptors that belong to superfamily G protein-coupled (GPCRs) are regulated by endogenously expressed agonists antagonists. aim this study was explore potential replacing disulfide bridge chimeric AGRP-melanocortin peptide...
NFU1, a late-acting iron-sulfur (Fe-S) cluster carrier protein, has key role in the pathogenesis of disease, multiple mitochondrial dysfunctions syndrome. In this work, using genetic and biochemical approaches, we identified initial scaffold ISCU (ISCU2) secondary carrier, ISCA1, as direct donors Fe-S clusters to which appears dimerize reductively mediate formation bridging [4Fe-4S] cluster, aided by ferredoxin 2. By monitoring abundance target proteins that acquire their from characterized...
Face detection and eyes extraction has an important role in many applications such as face recognition, facial expression analysis, security login etc. Detection of human structures like eyes, nose are the complex procedure for computer. This paper proposes algorithm from frontal images using Sobel edge morphological operations. The proposed approach is divided into three phases; preprocessing, identification region, eyes. Resizing gray scale image conversion achieved preprocessing. region...
Classical and more recent preparations of biguanidines, guanylureas guanylthioureas are summarized, together with their biological activity other applications.Biguanides depicted in most stable tautomeric form, modified where necessary from that the literature.
Abstract Broad ligament is the common extrauterine site for fibroid. We present a case of huge broad fibroid with cystic degeneration. Patient presented abdominal swelling and mild pain abdomen. On examination, large tense mass 34 weeks gravid uterus size arising from pelvis was noted. Cervix pulled up all fornices were full on pelvic examination. Ultrasound suggested adnexal as ovaries not seen. Contrast‐enhanced computed tomography abdomen too reported likely ovarian origin. laparotomy, 6...