A5086628419- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Axon Guidance and Neuronal Signaling
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Ocular and Laser Science Research
- Nerve Injury and Rehabilitation
- Retinopathy of Prematurity Studies
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
Stevens Institute of Technology
2013-2020
New Jersey Institute of Technology
2010
Artificial nerve guidance conduits (NGCs) are being investigated as an alternative to autografts, since autografts limited in supply. A polycaprolactone (PCL)-based spiral NGC with crosslinked laminin on aligned nanofibers was evaluated vivo post a successful vitro assessment. PC-12 cell assays confirmed that the functionalized were able guide and enhance neurite outgrowth. In rodent model, data demonstrated axons regenerate across critical gap, when present. Without laminin, group resulted...
Abstract Nerve guidance conduits (NGCs) are artificial substitutes for autografts, which serve as the gold standard in treating peripheral nerve injury. A recurring challenge tissue engineered NGCs is optimizing cross‐sectional surface area to achieve a balance between allowing infiltration while supporting maximum axonal extension from proximal distal stump. In this study, we address issue by investigating efficacy of an NGC with higher composed spiral structures and multi‐channels, coupled...
Abstract The inability to compare directly different nerve grafts has been a significant factor hindering the advance of graft development. Due abundance variables that exist in construction and multiple assessment types, there limited success comparing effectiveness among experiments. Using mathematical techniques on conduction velocity ( NCV ) autograft data, normalization function was empirically derived normalizes differences gap lengths. Further analysis allowed for development relative...
The inability to identify the optimal construction of a nerve guidance conduit (NGC) for peripheral regeneration is challenge in field tissue engineering. This attributed vast number parameters that can be combined varying quantities. A pre-existing normalization standard applied this paper which uses calculated ratio gap length divided by graft's critical axon elongation denoted as L/L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ....
Glaucoma is the degeneration of optic nerve head caused by elevated intraocular pressure (IOP) and diurnal variations. It second leading cause blindness. Proper treatment requires IOP to be monitored maintained. Goldmann applanation tonometry clinical gold standard measured in physician's office quarterly for those who are glaucoma suspects. a local anesthetic administered cornea. Hence, this procedure cannot utilized patient home monitoring. The proposed tonometer used at will use sensor...
Vergence eye movements are the inward and outward turning of eyes contemporary views believe these mediated by a preprogramming feedback controlled mechanism. The individual left right responses have been reported to large dynamic asymmetries between movements. One hypothesis explain observed asymmetry is preprogrammed transient component monocularly controlled. A visual stimulus was created stimulate single step change one double other using haploscope. Results show that in some...