Incidence rates of breast cancer are showing an increasing trend in young women (≤40 years) India. Risk for this age group can be attributed only partially to various known risk factors. Environmental exposure organochlorine (OC) compounds has been identified as a potential factor. However, the possible role OC not explored. This case-control study was planned with objectives assess serum levels compound North Indian population women.Forty-two patients ≤ 40 years and 42 age-matched controls...

Background The diverse manifestations of urolithiasis provide very interesting epidemiological data. This has prompted various studies to look into the etiopathogenesis renal stones, which is believed be multifactorial, both exogenous and endogenous. VDR Fok1 a risk factor for stone formation could cause stones through mechanism crystal induction crystallization in urine. While few recent have shown role heavy metals like cadmium lead current knowledge still insufficient. Methods...

Urinary bladder cancer (UBC) is a common disease worldwide with higher incidence rate in developed countries. Organochlorine pesticides (OCPs), potent endocrine disrupters, are found to be associated several cancers such as prostate, breast, b

Aim: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). Materials & methods: A randomized, double-blind controlled was undertaken among patients thoracic PHN where 30 received pregabalin with pulsed radiofrequency and controls sham treatment. Results: Pain intensity (visual analog scale) reduced earlier group (15.3 ± 5.7 at fourth week) compared control (16.3 6.6 eighth week). Serum level increased time both groups...

Background. Hypospadias is a part of testicular digenesis syndrome (TDS) which includes infertility, cryptorchidism, and spermatogenesis. Heavy metals act as endocrine disrupting compounds. such cadmium, chromium, arsenic, lead have been associated with male spermatogenesis, cancer, reproductive disorder, neurological disorder. However, it remains an important issue to corroborate or refute the hypothesis that role heavy in tract disorders. Hence, present study was designed investigate...

The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and role signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary.The observational following institutional ethical committee approval informed consent from all participants. A total 21 ASA grade I III with age 20-70 years, scheduled elective ovary were included. Patients excluded if had other causes pain, cognitive dysfunction or neurological disorders....

Background: Organochlorine pesticides (OCPs) exposure may induce an endocrine disruption which lead to the risk of developing diabetes through alteration and disturbance glucose metabolism, insulin resistance, destruction β-cells. The present study determines recent trend OCPs residue in blood samples their association with known factors responsible for among North Indian population.Methods: Blood sample 300 patients (100 each normal tolerance [NGT], prediabetes newly detected mellitus [DM])...

Preterm birth (PTB) is an important cause of prenatal death, neonatal morbidity and mortality adult illness. Increased inflammation occurs in normal parturition, inflammatory cytokines oxidative stress are found to be higher PTB cases. The present study was planned investigate the association organochlorine pesticides (OCPs) with mRNA expression pathway genes such as tumour necrosis factor-alpha (TNF-α) cyclooxygenase-2 (COX-2) preterm delivery (PTD) cases.Maternal blood samples PTD (n=30)...

Recent studies have shown that there is an increased risk of Epithelial Ovarian Cancer (EOC) with Organochlorine Pesticides (OCPs). However, the alteration in gene expression profile has not been explored so far. The goal present study to understand probable molecular mechanism OCPs toxicity towards discovery dysregulation signaling pathway associated differential and candidate transcriptomic set markers pathophysiology EOC exposed population.The OCP levels were estimated by gas...

The transformation of ovarian surface epithelial cells, stromal sex cord, or germ cells initiates malignancy. Epithelial cancer (EOC) is clinically silent with vague, non-specific symptomatology and generally diagnosed at an advanced stage, resulting in a high mortality rate. known main etiological factors are: age menarche menopause (early late menopause), use oral contraception (estrogen and/or progesterone), family history, genetic factors, inflammation, occupational environmental...

Exposure to dichlorodiphenyltrichloroethane (DDT), a potent lipophilic organochlorine pesticide, has long been linked as risk factor for type 2 diabetes mellitus (T2DM). However, its presence in the adipose tissues of T2DM subjects not explored Indian population, where this long-banned pesticide is still use. The present study was conducted evaluate possible association DDT and metabolites obese non-obese subjects.Subjects with normal glucose tolerance (n = 50) were divided into equal...

Background . Organochlorine pesticides (OCP) are persistent organic pollutants that have been implicated in causing several deleterious effects humans. These known neurotoxins high doses, but the role of environmentally acquired OCPs body to induce seizures children has not investigated yet. Objectives To assess serum levels aged 2–12 with idiopathic seizure and find out any association between two our objectives. Methods It was a cross-sectional pilot study. Twenty developmentally normal...

Objectives: This study aimed to compare the efficacy of yoga combined with an integrated multimodal approach on incidence and severity post-mastectomy pain syndrome (PMPS) role miR-133B expressions in patients undergoing breast cancer surgery. Methods: With approval from institutional ethics committee informed consent obtained each participant, forty ASA grade I - II, aged 20 65 years, surgery were included. Patients received a thoracic paravertebral block for up 72 hours pregabalin until...

Urinary bladder cancer (UBC) is one of the most common malignancies worldwide. The etiology UBC multifactorial and includes both exogenous endogenous factors. Exogenous risk factors include exposure to heavy metals, aromatic amines, environmental pollutants including pesticides such as organochlorine (OCPs). Environmental alone are incapable directly producing DNA damage may require activation by phase I metabolizing enzymes like cytochrome P450 in order become active carcinogen. present...

Background: Cerebral palsy is a common motor disability in childhood. Raised lead levels affect cognition. Children with cerebral may have raised levels, further impairing their residual cognitive and behavioral abilities. Environmental exposure abnormal eating habits to increased levels. Aims Objectives: To measure blood children compare them healthy neurologically normal children. correlate environmental factors. Material Methods:Design: Prospective case-control study. Setting: Tertiary...