A5080877931- Environmental Toxicology and Ecotoxicology
- Glutathione Transferases and Polymorphisms
- Heavy Metal Exposure and Toxicity
- Vitamin C and Antioxidants Research
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Physiological and biochemical adaptations
- Trace Elements in Health
- Aquaculture Nutrition and Growth
- Pesticide Exposure and Toxicity
- Birth, Development, and Health
- Selenium in Biological Systems
- Parasite Biology and Host Interactions
- Anesthesia and Neurotoxicity Research
- Estrogen and related hormone effects
- Coenzyme Q10 studies and effects
- Bat Biology and Ecology Studies
- Nitric Oxide and Endothelin Effects
- Aquatic Invertebrate Ecology and Behavior
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Amphibian and Reptile Biology
- Insect and Pesticide Research
- Computational Drug Discovery Methods
Klinikum rechts der Isar
2024
University of Belgrade
2009-2019
Institute for Biological Research “Siniša Stanković”
2007-2018
Institute for Biological Sciences
2003-2018
Institute of Biophysics
2002-2010
University of Kragujevac
2008
Czech Academy of Sciences, Institute of Physiology
1981-1992
University of London
1990
King's College London
1990
The effects of selenium (Se) on antioxidant defense system in liver and kidneys rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl(2) for 4 weeks) resulted increased lipid peroxidation (LP) both organs (p<0.005 p<0.01). Vitamin C (Vit C) was decreased the (p<0.005), whereas vitamin E E) p<0.05) Cd-exposed animals. Superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activities tissues (p<0.05 p<0.005), catalase (CAT) activity only...
Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with side effects such as nephrotoxicity. The present study investigated possible protective effect selenium (Se) against CP-induced oxidative stress rat kidneys. Male Wistar albino rats were injected a single dose cisplatin (7 mg CP/kg b.m., i.p.) and (6 Se/kg b.m, Na2SeO3, i.p.), alone or combination. obtained results showed that CP increased lipid...
Four groups of goldfish were exposed to cadmium in a concentration 20 mg Cd/l water under aquarium conditions. The duration exposure was 1, 4, 7 and 15 days. It shown that the activity superoxide dismutase (SOD) red blood cells (RBC) significantly decreased after first day exposure. However, SOD increased days treatment. Elevated catalase (CAT) found erythrocytes cadmium-treated fishes days, whereas plasma GOT levels GPT This accompanied by significant decrease hemoglobin concentrations...
The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well possible protective role vitamin E were studied. Male Wistar albino rats (3 months old) treated with (0.4 mg Cd/kg b.m., i.p., 24 h before experiment) or + Cd (20 IU Vit E/kg i.m., 48 0.4 experiment). parameters assessed: red cell counts, hematocrit value hemoglobin significantly decreased in Cd-treated rats. Intoxication was also followed...
This study investigated seasonal variations of antioxidant defense enzyme activities: total, manganese, copper zinc containing superoxide dismutase (Tot SOD, Mn CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), reductase (GR) and biotransformation phase II glutathione-S-transferase (GST) activity in the liver white muscle red mullet (Mullus barbatus). The investigations were performed winter spring at two localities: Near Bar (NB) Estuary River Bojana (EB) Southern Adriatic Sea. At...
The aim of this study was to investigate the protective effects oestradiol (E2, 4 mg kg-1 b.w. i.p.) against cadmium-induced (Cd, 2 blood changes in rats. Cadmium induced a significant decline haemoglobin, haematocrit, and total erythrocyte, lymphocyte, thrombocyte count, whereas leukocytes granulocytes increased. A increase also observed serum cholesterol, triglycerides, glucose, AST, ALT activities, protein albumin levels dropped significantly. Administration E2 combination with Cd...
The activities of total superoxide dismutase (Tot-SOD), manganese-containing (Mn-SOD), copper zinc containing (Cu/Zn-SOD) and catalase (CAT) protein concentration, as well SOD electrophoretic profiles in the liver muscle barbel (Barbus barbus) its intestinal parasite Pomphoryinchus laevis from river Danube, within suburban area Belgrade, Serbia (the stretch between Visnjica Grocka) spring summer were investigated. Specific Tot-SOD, Mn-SOD, Cu/Zn-SOD higher spring, while specific CAT activity...
Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q 10 (CoQ ) and vitamin E (VE), naturally occurring antioxidants, improve health condition inactivating free radicals enhancing antioxidative defence. The aim of our study was to investigate the protective role CoQ and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with (20 mg/kg b.w.) IU/kg or saline (control...