A5018179048- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Chronic Myeloid Leukemia Treatments
- Genomics and Rare Diseases
- PI3K/AKT/mTOR signaling in cancer
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Amino Acid Enzymes and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Plant pathogens and resistance mechanisms
- Cleft Lip and Palate Research
- CRISPR and Genetic Engineering
- Craniofacial Disorders and Treatments
- Acute Myeloid Leukemia Research
- Plant Virus Research Studies
- Mast cells and histamine
- Plant Disease Resistance and Genetics
- Advanced biosensing and bioanalysis techniques
University of California, Irvine
2011-2014
City Of Hope National Medical Center
2013-2014
Identification of proteins in RNA-protein complexes is an important step toward understanding regulation RNA-based processes. Because the lack appropriate methodologies, many studies have relied on creation vitro assembled using synthetic RNA and cell extracts. Such may not represent authentic RNPs as they exist living cells fold properly nonspecific interactions can form during lysis purification To circumvent limitations current approaches, we developed a novel integrated strategy namely...
Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational therapy (TBT). Initial results demonstrate need more potent drugs an in vivo model system quantitative assessment of TBT. Herein, we present evaluating efficacy premature stop codon management therapies: repli-sampling TBT assay (IQSCMaRTEA). Application IQSCMaRTEA reveals that geneticin is much efficacious than gentamicin. Treatment with elicits a multiday response, residual F9 antigen be detected...
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription factor important for cell survival and metastasis cancer, is produced via IRES-directed translation, its mRNA frequently upregulated malignancies, including chronic myeloid leukaemia (CML). In this study, we determined LEF1 regulated by Bcr-Abl, the...
Vol.10 (2011) 1–15 DOI:10.1074/mcp.A110.007385 Lan Huang is co-author with Marian Waterman. The online version of this article reflects change.
Missense, nonsense, splice site and regulatory region variants in interferon factor 6 (IRF6) have been shown to contribute both syndromic non-syndromic forms of cleft lip and/or palate (CL/P). We report the diagnostic evaluation a complex multigeneration family Honduran ancestry with pedigree structure consistent autosomal-dominant inheritance incomplete penetrance variable expressivity. The proband’s grandmother bore children two partners CL/P segregates on sides each lineage. Through...