A5005689323- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- COVID-19 and Mental Health
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Advanced Neuroimaging Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Dialysis and Renal Disease Management
- Medical Practices and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Botulinum Toxin and Related Neurological Disorders
- Blood Pressure and Hypertension Studies
- Physical Activity and Health
- Psychosomatic Disorders and Their Treatments
- Restless Legs Syndrome Research
RWTH Aachen University
2014-2025
Forschungszentrum Jülich
2019-2025
Jülich Aachen Research Alliance
2014-2025
Universitätsklinikum Aachen
2012-2024
Instituto Nacional do Câncer
2023
Hospital Prof. Dr. Fernando Fonseca
2023
Metropolitan University
2022
Hospital Braga
2014-2021
Escola Superior de Saúde Egas Moniz
2021
Celulose Beira Industrial (Portugal)
2021
We aimed to objectify and compare persisting self-reported symptoms in initially hospitalized non-hospitalized patients after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by applying clinical standardized measures.We conducted a cross-sectional study of adult confirmed SARS-CoV-2 including medical history, neurological examination, blood markers, neuropsychological testing, patient-reported outcome measures (PROMs), brain magnetic resonance imaging (MRI).Fifty...
Background Physical activity and fitness are major targets in Alzheimer's disease (AD) preventive research. However, current research is heterogeneous often disregards the relationship between these parameters outcomes. Objective To assess effects of physical on AD within context a multicomponent sports intervention. Methods 46 participants with early-stage (mean age 70 ± 7 years, 18 women, mean Montreal Cognitive Assessment (MoCA) score 19±5) were included six-month randomized controlled...
Background Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) therapy have an increased risk of developing cognitive impairment and dementia, which are known relevant factors in prognosis therapeutic success, but still lack adequate screening clinical routine. We evaluated the Montreal Cognitive Assessment (MoCA) for suitability assessing performance HD comparison to commonly used Mini-Mental State Examination (MMSE) a detailed neuropsychological test battery, as gold...
Spinocerebellar ataxias are dominantly inherited disorders that associated with progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of multicentre European integrated project on spinocerebellar study, 37 patients ataxia-1, 19 ataxia-3 seven ataxia-6 were clinically examined underwent magnetic resonance imaging at baseline after a 2-year follow-up. All compared age-matched gender-matched healthy control subjects. Magnetic analysis included three-dimensional...
Aims: The Montreal Cognitive Assessment (MoCA) has gained recognition for its validity in detecting cognitive impairment several clinical populations. For serial assessments, alternate forms are needed to overcome possible practice effects. Our objective was investigate the reliability of two German MoCA longitudinal assessment applications. Methods: original and one were administered within a 60-min interval interview counterbalanced order 100 healthy elderly controls, 30 patients with mild...
Abstract Background The SARS-Coronavirus-2 (SARS-CoV-2) invades the respiratory system, causing acute and sometimes severe pulmonary symptoms, but turned out to also act multisystematically with substantial impact on brain. A growing number of studies suggests a diverse spectrum neurological manifestations. To investigate we here describe manifestations complications patients proven SARS-CoV-2 infection who have been hospitalized at RWTH University Hospital Aachen, Germany. Methods Between...
Abstract Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic structural imaging alterations in have been identified, their functional consequences remain unknown. Thus, we explored the impact of on connectome brain providing deeper understanding pathophysiological mechanisms. In cross-sectional observational study, resting-state magnetic resonance data 66 patients with after...
Friedreich's ataxia (FRDA) is a spinocerebellar degenerative disorder, in which cognitive deficits are sparsely explored. In this behavioral and multimodal magnetic resonance imaging (MRI) study, we investigated the neurocognitive profile cortico-cerebellar dysfunctions underlying executive functioning individuals with FRDA.22 FRDA patients 22 controls were clinically neuropsychologically examined. Fifteen of each underwent structural functional MRI using verbal-fluency task phonemic...
<b><i>Background/Aims:</i></b> There is an increasing interest in using the Montreal Cognitive Assessment (MoCA) test as a monitoring tool Alzheimer's disease (AD) both research and clinical settings. Our aim was to investigate utility of alternate forms MoCA detecting cognitive deterioration sample early AD patients followed longitudinally outpatient memory clinic. <b><i>Method:</i></b> Twenty-five with early-stage (prodromal or mild dementia)...
<i>Background:</i> Parkinson’s disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of disease. A particularly disabling symptom dementia. <i>Methods/Design:</i> The study designed as multicentre prospective, observational cohort about 700 PD patients aged 45–80 years with or without dementia and PD-mild cognitive impairment (MCI). will be recruited in eight specialized movement disorder clinics...
Abstract Background Sexual dysfunction in women with Parkinson's disease is poorly understood and research this area scarce. The objectives of study were sexual function characterization female patients, description dysfunctions, correlation characteristics, comparison matched healthy controls. Methods Social demographic data from consecutive patients controls collected. following instruments used: UPDRS, the Hoehn Yahr scale, Beck Depression Inventory‐II, Female Function Index, Dysfunction...
Abstract Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about occurrence stroke AD patients. We aimed to quantify risk patients with and compare incidence rates (IR) individuals without AD. Systematic search Embase MEDLINE between 1970 2020. Inclusion criteria: reports ≥ 50 non-familial AD, which reported (all types) and/or ischemic intracerebral hemorrhage (ICH) during follow-up. Meta-analyses pooled data using...
Abstract Background Friedreich ataxia is a rare neurodegenerative disorder caused by frataxin deficiency. Both underweight and overweight occur in mitochondrial disorders, each with adverse health outcomes. We investigated the longitudinal evolution of anthropometric abnormalities hypothesis that both weight loss gain are associated faster disease progression. Methods Participants were drawn from European Friedreich's Ataxia Consortium for Translational Studies (EFACTS). Age‐ sex‐specific...
Up to 10% of SARS-CoV-2 infected individuals suffer from post-COVID-19 condition, marked by fatigue and cognitive dysfunction as major symptoms. Longitudinal studies on neuropsychological clinical trajectories related brain changes are scarce. Here, we aimed examine their evolution up 2 years post-infection. In a multi-center, longitudinal study 79 post-COVID patients (mean age 46, 48 female) with persistent symptoms 21 age- sex-matched never-infected, healthy controls 42, eight female),...
The aim of this study was to investigate the frequency and severity neuropsychiatric symptoms (NPS) in patients with early onset Alzheimer's disease (EAOD) late AD (LOAD).
<b><i>Background:</i></b> Intracerebral hemorrhage (ICH) recurrence risk is known to be higher in patients with cerebral amyloid angiopathy (CAA) as compared other causes of ICH. Risk factors for ICH are not completely understood, and our goal was study specific imaging microangiopathy markers. <b><i>Methods:</i></b> Retrospective case-control non-traumatic admitted a single center between 2014 2017 who underwent magnetic resonance (MRI)....
The Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) incorporated non-hemorrhagic imaging markers. Their prevalence and significance in patients with cognitive impairment remain uncertain.