A5004526951- Veterinary Equine Medical Research
- Veterinary Practice and Education Studies
- Animal Disease Management and Epidemiology
- Muscle Physiology and Disorders
- Advanced Fluorescence Microscopy Techniques
- Calpain Protease Function and Regulation
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Hereditary Neurological Disorders
- Physiological and biochemical adaptations
- Advancements in Transdermal Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Papaya Research and Applications
- Plant Reproductive Biology
- Identification and Quantification in Food
- Spectroscopy and Chemometric Analyses
- Genetic and phenotypic traits in livestock
- Plant Micronutrient Interactions and Effects
- Meat and Animal Product Quality
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Plant and animal studies
- Mitochondrial Function and Pathology
- Skin Protection and Aging
- Plant Surface Properties and Treatments
University of Lausanne
2023
Yves Rocher (France)
2016-2020
Cyclacel Pharmaceuticals (United Kingdom)
2008
Institut National de la Recherche Agronomique
2003-2005
Instituto Venezolano de Investigaciones Científicas
1985
Calpain 1, a ubiquitous calcium‐dependent intracellular protease, was recently found in tight association with myofibrils skeletal muscle tissue [Delgado EF, Geesink GH, Marchello JA, Goll DE & Koohmaraie M (2001) J Anim Sci 79 , 2097–2107). Our immunofluorescence and immunoelectron microscopy investigations restrain the protease location at periphery of Z‐band midpoint I‐band. Furthermore, calpain 1 is to localize myofibril fractures, described as proteolysis sites, postmortem bovine...
Calpain 1 behaviour toward cytoskeletal targets was investigated using two alpha-actinin isoforms from smooth and skeletal muscles. These which are, respectively, sensitive resistant to calpain cleavage, interact with the protease when in vitro binding assays. The stability of complexes EGTA [Kd(-Ca2+) = 0.5 +/- 0.1 microM] improved presence mm calcium ions [Kd(+Ca2+) 0.05 0.01 microM]. Location structures shows that C-terminal domain each subunit, 28 80 kDa, participates interaction. In...
We compared hyperspectral infrared raster maps and images for contrast, definition resolution of the same samples recorded with a confocal microscope coupled synchrotron radiation source vs Focal Plane Array (FPA) detector equipped microscope. Biological (hair skin sections) astrophysics (meteoritic grains) were used. The presented are few microns in size, such as embedded particles, single unique cell or thin layer. Our results show that actual spatial contrast FPA lower than spectral from...
The evidence presented here indicates that ferric citrate inhibits both the phytohemagglutinin-induced lymphocyte proliferation and formation of E rosettes by T lymphocytes. These inhibitory effects are only observed in presence with a metal to ligand molar ratio (1:1) but not (1:20) or sodium citrate. Since at physiological pH tends hydrolyze polymerize, we suggest effect is mediated iron polymers.
The human epidermis presents a complex organization due to its dynamic and plein-stratified epithelium. Still nowadays, one of the best method study this layer skin remains histology sections. This approach tedious gives only 2D information.Rhodamine B is dye known have high affinity for epidermal possess fluorescent properties. Associated with clarification such as 3DiSCO, maintains fluorescence emission. which became transparent can then be investigated Laser Scanning Confocal...
Abstract Decreased ryanodine receptor type 1 (RyR1) protein is a hallmark of recessive RYR1 -related myopathies ( RyR1 -RM), which are caused by mutations in the gene. It not clear how decrease triggers muscular disorders. Furthermore, it hot topic whether levels can also occur during non- myopathies. In this study, we first show that reduced transcripts associated with various human myopathies, and significantly decreased muscle samples analysed inflammatory (IM) mitochondrial (MM), both...