A5026526859- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
Chonnam National University
2020-2021
Harvard University
2012
Lysine 40 acetylation of α-tubulin (Ac-α-tubulin), catalyzed by the acetyltransferase αTAT1, marks stabilized microtubules. Recently, there is growing evidence to suggest crosstalk between DNA damage response (DDR) and microtubule organization; we therefore investigated whether αTAT1 involved in DDR. Following treatment with DNA-damaging agents, increased levels Ac-α-tubulin were detected. We also observed significant induction after depletion repair proteins, suggesting that positively...
The deubiquitinating enzyme USP1 contains highly conserved motifs forming its catalytic center. Recently, the COSMIC mutation database identified a in at Asp-199 endometrial cancer. Here, we investigated role of for function. aspartic acid to alanine (D199A) resulted failure undergo autocleavage and form complex with ubiquitin, indicating D199A Usp1 is catalytically inactive. did not affect interaction Uaf1. Moreover, had defects deubiquitination FANCD2 PCNA displayed reduced foci formation...