A5091108521- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Management of metastatic bone disease
- Radiation Shielding Materials Analysis
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Spinal Fractures and Fixation Techniques
- Lymphoma Diagnosis and Treatment
- Cancer Risks and Factors
- Digital Radiography and Breast Imaging
- Breast Cancer Treatment Studies
- Immune Response and Inflammation
- Lung Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Cervical and Thoracic Myelopathy
University of Iowa
2004-2016
University of Iowa Hospitals and Clinics
2004-2008
University of Iowa Health Care
2008
University of Wisconsin–Madison
2002
To evaluate conventional brachytherapy (BT) plans using dose-volume parameters and high resolution (3 Tesla) MRI datasets, to quantify dosimetric benefits limitations when MRI-guided, conformal BT (MRIG-CBT) are generated.Fifty-five clinical high-dose-rate from 14 cervical cancer patients were retrospectively studied. All created with titanium tandem-and-ovoid applicator (T&O) for delivery. For each plan, a MRIG-CBT plan was generated hybrid inverse optimization. Three categories of risk...
The objective of this work is to present commissioning procedures clinically implement a three-dimensional (3D), image-based, treatment-planning system (TPS) for high-dose-rate (HDR) brachytherapy (BT) gynecological (GYN) cancer. physical dimensions the GYN applicators and their values in virtual applicator library were varied by 0.4 mm nominal values. Reconstruction uncertainties titanium tandem ovoids (T&O) less than on CT phantom studies average between 0.8-1.0 MRI when compared with...
For static beam conformal intracranial radiosurgery, geometry of the arrangement dominates overall dose distribution. Maximizing separation in three dimensions decreases overlap, thus maximizing conformality and gradient outside target volume. Webb proposed arrangements isotropically convergent beams that could be used as starting point for a radiotherapy optimization process. We have developed an extracranial radiosurgery method by extending Webb's isotropic to deliverable arrangements....
In a previous article, we presented development and verification of an integral transport equation‐based deterministic algorithm for computing three‐dimensional brachytherapy dose distributions. Recently, have included fluorescence radiation physics parallel computation to the standing algorithms so that can compute distributions large set seeds without resorting superposition methods. The introduction capability provided means distribution multiple in simultaneous manner. This way study...
The purpose of this study was to evaluate the feasibility assessing bladder and rectal point doses, using orthogonal radiographs without treatment planning, for vaginal cylinder applicator (VC), high-dose-rate (HDR) cuff brachytherapy (BT) after hysterectomy. Thirty-three VC HDR BT plans from 31 postop- erative endometrial cancer patients were retrospectively analyzed. Single-channel with four differing diameters - 2.0 cm, 2.3 2.6 3.0 cm Dose-distance modeling performed estimate doses by...
Purpose: Characterize 3 Tesla (T) magnetic resonance image (MRI) distortion and artifacts induced from a titanium applicator presence. Method Materials : Based on the ASTM International method, tandem ovoids (Varian) was placed in reference phantom, embedded solution (30L distilled water, 1.5g/L CuSO4). A phantom designed to be free distortion, suspend an applicator, provide for distortion. MR images were scanned transverse, sagittal, coronal views; also generated both with without place....
Purpose: To develop an easily‐made, interchangeable prostate brachytherapy phantom for implant training and/or dummy‐run treatment planning that is feasible ultrasound (US), CT and MRI guidance. Commercially available phantoms are expensive not reusable repeated practice. Methods: The consists of two parts: a multiple use lower transrectal‐ultrasound part upper part. Material composition was iteratively updated based upon each scan US, CT, MRI. Image quality on evaluated in terms the...
The Low-Energy Photon-Scattering (LSCAT) expansion to the EGS4 Monte Carlo code has been applied "scatter sphere" scasph.mortran compute energy deposition kernels at photon energies below 100 keV. LSCAT routines were used replace default atomic form factor and cross-section data by model coherent scatter with measured molecular data. Energy calculated with: (1) effects neglected, (2) included using factor, (3) factor. These utilized in a convolution/superposition developed for mega-voltage...
Purpose: Verify a volume‐based optimization algorithm against classic line‐based one for intracavitary high‐dose‐rate (HDR) brachytherapy (BT) treatment planning cervical cancer. Method and Materials: This retrospective study reviewed ten randomly selected tandem ovoids plans. To investigate the dose‐behavior induced by different algorithms, no variations in T&O applicator geometry imaging dataset were made. Three metrics employed: 1) total reference air kerma (TRAK), 2) volume enclosed...
s for the 19th Annual Scientific Meeting of International Society Biological Therapy Cancer, San Francisco, California, November 4-7, 2004: Immune Adjuvants