A5101716843- Geological and Geochemical Analysis
- Virus-based gene therapy research
- earthquake and tectonic studies
- Geochemistry and Geologic Mapping
- Geology and Paleoclimatology Research
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- HIV Research and Treatment
- Poxvirus research and outbreaks
- Hepatitis B Virus Studies
- Cryospheric studies and observations
- Vector-Borne Animal Diseases
- High-pressure geophysics and materials
- Transgenic Plants and Applications
- Polar Research and Ecology
Kyoto University
1988-2022
National Vaccine and Serum Institute
1987
We constructed recombinant vaccinia viruses (RVVs) that expressed human T-cell leukemia virus type I (HTLV-I) envelope glycoproteins by using attenuated (VVs) which have much lower neurovirulence than the WR strain is extensively used as a vector. The RVV produced from LC16mO strain, one of VVs, elicited high titer anti-HTLV-I antibody in rabbits and protected them against HTLV-I infection. env gene was inserted into VV hemagglutinin gene. resultant inactivation led to attenuation but extent...
The metamorphic pressure–temperature (P–T) conditions of high–grade pelitic gneisses from Akarui Point, Skarvsnes, Skallen, and Rundvågshetta in the Lützow–Holm Complex (LHC), East Antarctica are re–examined by applying Zr–in–rutile geothermometer to rutile inclusions garnet enclosing Al2SiO5 minerals matrix grains. By utilizing P zoning indicate isochronous surface, samples Skallen were shown have experienced almost same P–T around kyanite/sillimanite transition boundary (~ 830–850 °C/~ 11...
We prepared vaccinia virus variants by introducing part of the HindIII D fragment DNA parental Lister (LO) strain (temperature-resistant and forming large plaques pocks) into attenuated LC16m8 (temperature-sensitive small use a homologous recombination technique in vivo. Special attention was paid to fragment, since this has an extra XhoI site which is absent from LO. After LO introduced as calcium phosphate precipitate rabbit kidney (RK13) cells had been infected with LC16m8, five (LOTC-1...
Abstract Solidification pressures and ages of mafic microgranular enclaves (MMEs) their host granite were determined compared based on Al‐in‐hornblende geobarometry U–Pb zircon dating in two sample localities the Kurobegawa Granite. In KRG19‐A03 from middle unit pluton, MME yielded 0.18 ± 0.03 to 0.24 0.04 GPa 0.16 0.23 GPa, respectively. The KRG19‐B08b lower unit, respectively, 0.12 0.02 0.21 0.13 GPa. each locality, estimated solidification its overlap. weighted mean calculated as 0.775...
<p>The Zr content of rutile coexisting with zircon and quartz is mainly a function the temperature condition calibrated as Zr-in-rutile geothermometers. Because their robustness under high-temperature conditions, they have been applied to granulite facies rocks instead conventional Fe-Mg exchange type geothermometers estimate more reliable conditions. However, it recently pointed out that in order for retain primary content, must be chemically isolated from during cooling. In...